MTNR1A and PGRMC1

Number of citations of the paper that reports this interaction (PMID 17215244)
14

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		MTNR1A	PGRMC1
Gene Name		melatonin receptor 1A	progesterone receptor membrane component 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex	Nucleolus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Melatonin Receptor Activity Hormone Binding Organic Cyclic Compound Binding	Steroid Binding Protein Binding Heme Binding
	Biological Process	G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Mating Behavior Circadian Rhythm Positive Regulation Of CGMP Biosynthetic Process	Axon Guidance
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		Ramelteon Melatonin Agomelatine
Diseases
GWAS		Obesity ( 21552555)
Protein-Protein Interactions		26 interactors: CALR CANX CNP DPM1 EEF1G FLNA GNA11 GNA13 GNAI1 GNAI2 GNAI3 GNB1 GNB4 GPR50 HNRNPA0 HSPA5 IRS4 LRRC59 MTNR1B PDIA6 PGRMC1 RAB10 RAC1 RAP1A TMEM33 VAPB	5 interactors: CENPU CREB3L1 MTNR1A PAM16 SCAP
Entrez ID		4543	10857
HPRD ID		02812	02338
Ensembl ID		ENSG00000168412	ENSG00000101856
Uniprot IDs		P48039	O00264 Q6IB11
PDB IDs
Enriched GO Terms of Interacting Partners?		Platelet Activation G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Blood Coagulation Hemostasis Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Body Fluid Levels Wound Healing Cell Activation Response To Wounding Signaling Cell Communication Response To Stimulus G-protein Coupled Receptor Signaling Pathway Signal Transduction Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Response To Organic Substance Positive Regulation Of Nuclease Activity Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Kinase Activity Vesicle-mediated Transport Positive Regulation Of Transferase Activity Response To Stress Synaptic Transmission Cell-cell Signaling Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein ER-nucleus Signaling Pathway Cellular Response To Stimulus Cellular Response To Topologically Incorrect Protein Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Kinase Activity Dopamine Receptor Signaling Pathway Substantia Nigra Development Cellular Response To Organic Substance Response To Unfolded Protein Regulation Of Kinase Activity Membrane Organization Positive Regulation Of Phosphorylation Response To Endoplasmic Reticulum Stress Cell Surface Receptor Signaling Pathway Neural Nucleus Development Positive Regulation Of Protein Modification Process Ras Protein Signal Transduction Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Response To Peptide Hormone Midbrain Development G-protein Coupled Acetylcholine Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process	ER-nucleus Signaling Pathway Negative Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Protein Import Into Mitochondrial Matrix Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process SREBP Signaling Pathway Negative Regulation Of ATPase Activity Positive Regulation Of Receptor Biosynthetic Process Response To Sterol Depletion Positive Regulation Of Cellular Biosynthetic Process Regulation Of Metabolic Process Regulation Of Receptor Biosynthetic Process Positive Regulation Of CGMP Biosynthetic Process Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of CGMP Metabolic Process Regulation Of CGMP Biosynthetic Process Negative Regulation Of Steroid Biosynthetic Process Negative Regulation Of Steroid Metabolic Process CENP-A Containing Nucleosome Assembly Regulation Of Cholesterol Metabolic Process Regulation Of Fatty Acid Biosynthetic Process Regulation Of CGMP Metabolic Process Histone Exchange Mating Behavior DNA Replication-independent Nucleosome Assembly Regulation Of Nitrogen Compound Metabolic Process Regulation Of ATPase Activity Negative Regulation Of Lipid Biosynthetic Process Centromere Complex Assembly Intracellular Protein Transmembrane Transport Positive Regulation Of Cellular Metabolic Process
Tagcloud ?			abeta25 ag205 alleviated attempted attenuate attenuates brings broadly classic complementary entitled exerts inhibiting insults jnk mitochondria nervous neuroprotection neuroprotections neuroprotective neurosteroid pr progesterone protected protective rescuing ru486 special steroids
Tagcloud (Difference) ?			abeta25 ag205 alleviated attempted attenuate attenuates brings broadly classic complementary entitled exerts inhibiting insults jnk mitochondria nervous neuroprotection neuroprotections neuroprotective neurosteroid pr progesterone protected protective rescuing ru486 special steroids
Tagcloud (Intersection) ?