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GNA13 and ARHGEF11
Number of citations of the paper that reports this interaction (PMID
10026210
)
71
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo)
GNA13
ARHGEF11
Gene Name
guanine nucleotide binding protein (G protein), alpha 13
Rho guanine nucleotide exchange factor (GEF) 11
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Heterotrimeric G-protein Complex
Plasma Membrane
Focal Adhesion
Membrane
Brush Border Membrane
Melanosome
Extracellular Vesicular Exosome
Intracellular
Cytoplasm
Cytosol
Membrane
Molecular Function
GTPase Activity
Signal Transducer Activity
Protein Binding
GTP Binding
G-protein Beta/gamma-subunit Complex Binding
Type 1 Angiotensin Receptor Binding
D5 Dopamine Receptor Binding
Metal Ion Binding
G-protein Coupled Receptor Binding
Rho Guanyl-nucleotide Exchange Factor Activity
GTPase Activator Activity
Protein Binding
Biological Process
Patterning Of Blood Vessels
In Utero Embryonic Development
Movement Of Cell Or Subcellular Component
Signal Transduction
Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Rho Protein Signal Transduction
Blood Coagulation
Regulation Of Cell Shape
Cell Differentiation
Platelet Activation
Regulation Of Cell Migration
Activation Of Phospholipase D Activity
Cytokinesis
Regulation Of Cell Growth
Movement Of Cell Or Subcellular Component
Striated Muscle Contraction
G-protein Coupled Receptor Signaling Pathway
Small GTPase Mediated Signal Transduction
Rho Protein Signal Transduction
Axon Guidance
Establishment Of Cell Polarity
Actin Cytoskeleton Organization
Positive Regulation Of Rho GTPase Activity
Termination Of G-protein Coupled Receptor Signaling Pathway
Positive Regulation Of Apoptotic Process
Positive Regulation Of Transcription, DNA-templated
Neurotrophin TRK Receptor Signaling Pathway
Regulation Of Small GTPase Mediated Signal Transduction
Apoptotic Signaling Pathway
Pathways
Thrombin signalling through proteinase activated receptors (PARs)
Signaling by GPCR
GPCR downstream signaling
Thromboxane signalling through TP receptor
G alpha (12/13) signalling events
Signal amplification
Platelet activation, signaling and aggregation
Signaling by GPCR
Signalling by NGF
Axon guidance
Semaphorin interactions
Cell death signalling via NRAGE, NRIF and NADE
p75 NTR receptor-mediated signalling
Rho GTPase cycle
GPCR downstream signaling
NRAGE signals death through JNK
Signaling by Rho GTPases
G alpha (12/13) signalling events
Sema4D in semaphorin signaling
Sema4D induced cell migration and growth-cone collapse
Drugs
Diseases
GWAS
Protein-Protein Interactions
31 interactors:
AIP
AKAP3
ARHGEF1
ARHGEF11
ARHGEF12
CDH1
CDH2
CTNNB1
CXCR4
DRD5
EDNRB
F2R
GNA12
GPR17
MCF2
MTNR1A
PPP5C
PRKACA
PRKCB
PRKCD
PRKCE
PTK2B
RDX
RGS16
RIC8A
S1PR2
S1PR3
S1PR4
TBXA2R
TGFBR1
TSHR
13 interactors:
ABCA1
CDC42
GNA12
GNA13
LPAR1
LPAR2
MAP1A
MAP1B
PLXNB1
PLXNB2
PLXNB3
RHOA
SLC1A6
Entrez ID
10672
9826
HPRD ID
05100
09302
Ensembl ID
ENSG00000120063
ENSG00000132694
Uniprot IDs
B7Z7R0
F5H1G8
Q14344
F8W8P9
O15085
PDB IDs
1HTJ
1XCG
2DLS
3KZ1
3T06
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Metabolic Process
Regulation Of Intracellular Signal Transduction
Signal Transduction
Positive Regulation Of Catalytic Activity
Cellular Calcium Ion Homeostasis
Calcium Ion Homeostasis
G-protein Coupled Receptor Signaling Pathway
Signaling
Regulation Of Signaling
Cell Communication
Regulation Of Catalytic Activity
Regulation Of Signal Transduction
Cellular Response To Stimulus
Cytosolic Calcium Ion Homeostasis
Cellular Metal Ion Homeostasis
Cellular Cation Homeostasis
Cellular Ion Homeostasis
Metal Ion Homeostasis
Response To Organic Substance
Positive Regulation Of Cytosolic Calcium Ion Concentration
Cell Activation
Cellular Chemical Homeostasis
Ion Homeostasis
Apoptotic Process
Programmed Cell Death
Response To Stimulus
Positive Regulation Of Hydrolase Activity
Cellular Response To Organic Substance
Cell Death
Death
Chemical Homeostasis
Cellular Homeostasis
Regulation Of Cellular Process
G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Intracellular Signal Transduction
Regulation Of Metabolic Process
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of MAPK Cascade
Regulation Of MAPK Cascade
Platelet Activation
Homeostatic Process
Enzyme Linked Receptor Protein Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Negative Regulation Of Signaling
Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway
Regulation Of Phosphorus Metabolic Process
Neurotrophin Signaling Pathway
Positive Regulation Of Cellular Metabolic Process
Termination Of Signal Transduction
Regulation Of Cell Morphogenesis
Regulation Of Cell Projection Organization
Positive Regulation Of Cell Projection Organization
Positive Regulation Of Cell Morphogenesis Involved In Differentiation
Regulation Of Small GTPase Mediated Signal Transduction
Positive Regulation Of Axonogenesis
Positive Regulation Of Neuron Projection Development
Regulation Of Cellular Component Organization
Positive Regulation Of Cell Development
Cell Surface Receptor Signaling Pathway
Regulation Of Cell Migration
Regulation Of Cell Motility
Positive Regulation Of Neuron Differentiation
Regulation Of Rho Protein Signal Transduction
Regulation Of Locomotion
Regulation Of Intracellular Signal Transduction
Regulation Of Cellular Component Movement
Regulation Of Neuron Projection Development
Regulation Of Axonogenesis
Regulation Of Cell Shape
Semaphorin-plexin Signaling Pathway
Positive Regulation Of Neurogenesis
Regulation Of Cell Development
Positive Regulation Of Cell Differentiation
Apolipoprotein A-I-mediated Signaling Pathway
Rho Protein Signal Transduction
Axonogenesis
Generation Of Neurons
Signaling
Regulation Of Cell Differentiation
Regulation Of Neuron Differentiation
Cell Communication
Axon Development
Positive Regulation Of Phospholipase Activity
Anatomical Structure Morphogenesis
Neurogenesis
Cell Morphogenesis Involved In Neuron Differentiation
Cell Differentiation
Regulation Of Phospholipase Activity
Positive Regulation Of Lipase Activity
Neuron Projection Morphogenesis
Cell Projection Organization
Regulation Of Ras Protein Signal Transduction
Regulation Of Neurogenesis
Regulation Of Signal Transduction
Cell Morphogenesis Involved In Differentiation
Ossification Involved In Bone Maturation
Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Bone Maturation
Tagcloud
?
18q
19p13
1q
aberrations
arising
burkitt
collaborating
cooperate
copy
deep
enhancer
gains
id3
immunoglobulin
lymphoma
microrna
myc
next
profiling
recurrent
scope
sequencing
signatures
smarca4
subgroups
summary
transcriptome
widened
yielded
Tagcloud (Difference)
?
18q
19p13
1q
aberrations
arising
burkitt
collaborating
cooperate
copy
deep
enhancer
gains
id3
immunoglobulin
lymphoma
microrna
myc
next
profiling
recurrent
scope
sequencing
signatures
smarca4
subgroups
summary
transcriptome
widened
yielded
Tagcloud (Intersection)
?