GNA13 and EDNRB

Number of citations of the paper that reports this interaction (PubMedID 12135322)
0

Data Source:
HPRD (in vivo)

		GNA13	EDNRB
Description		G protein subunit alpha 13	endothelin receptor type B
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Heterotrimeric G-protein Complex Plasma Membrane Focal Adhesion Membrane Brush Border Membrane Melanosome Extracellular Exosome Postsynapse	Plasma Membrane Membrane Nuclear Membrane
	Molecular Function	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity G Protein Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding D5 Dopamine Receptor Binding Metal Ion Binding	G Protein-coupled Receptor Activity Endothelin Receptor Activity Protein Binding Peptide Hormone Binding Type 1 Angiotensin Receptor Binding
	Biological Process	Angiogenesis Branching Involved In Blood Vessel Morphogenesis In Utero Embryonic Development Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Regulation Of Blood Pressure Regulation Of Cell Shape Regulation Of Fibroblast Migration Cell Differentiation Platelet Activation Intracellular Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Postsynapse Assembly Rho-activating G Protein-coupled Receptor Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Neural Crest Cell Migration Renin Secretion Into Blood Stream Regulation Of Heart Rate Regulation Of PH Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Nervous System Development Peripheral Nervous System Development Posterior Midgut Development Regulation Of Blood Pressure Positive Regulation Of Cell Population Proliferation Gene Expression Negative Regulation Of Neuron Maturation Vein Smooth Muscle Contraction Vascular Associated Smooth Muscle Contraction Calcium-mediated Signaling CGMP-mediated Signaling Heparin Proteoglycan Metabolic Process Melanocyte Differentiation Regulation Of Fever Generation Aldosterone Metabolic Process Response To Lipopolysaccharide Enteric Smooth Muscle Cell Differentiation Positive Regulation Of Urine Volume Renal Sodium Excretion Epithelial Fluid Transport Vasoconstriction Vasodilation Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Pigmentation Developmental Pigmentation Macrophage Chemotaxis Response To Pain Enteric Nervous System Development Regulation Of Epithelial Cell Proliferation Negative Regulation Of Protein Metabolic Process Sodium Ion Homeostasis Canonical Wnt Signaling Pathway Positive Regulation Of Penile Erection Establishment Of Endothelial Barrier Renal Sodium Ion Absorption Calcium Ion Transmembrane Transport Cellular Response To Lipopolysaccharide Protein Transmembrane Transport Podocyte Differentiation Endothelin Receptor Signaling Pathway Renal Albumin Absorption Neuroblast Migration Chordate Pharynx Development Response To Sodium Phosphate Response To Endothelin
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events Thromboxane signalling through TP receptor Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) CDC42 GTPase cycle RAC1 GTPase cycle	Peptide ligand-binding receptors G alpha (q) signalling events Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs			Bosentan IRL-1620 Sitaxentan Ambrisentan Enrasentan Tezosentan Macitentan
Diseases			Hirschsprung disease (HD) Waardenburg syndrome (WS) ABCD syndrome Nasopharyngeal cancer
GWAS		Brain morphology (MOSTest) ( 32665545) Periventricular white matter hyperintensities ( 32517579) White matter microstructure (global fractional anisotropy) ( 24736177)	Appendicular lean mass ( 33097823) Craniofacial microsomia ( 26853712) Hair color ( 23548203 29662168) Total ventricular volume (Alzheimer's disease interaction) ( 21116278)
Interacting Genes		31 interacting genes: AIP AKAP3 ARHGEF1 ARHGEF11 ARHGEF12 CDH1 CDH2 CTNNB1 CXCR4 DRD5 EDNRB F2R GNA12 GPR17 MCF2 MTNR1A PPP5C PRKACA PRKCB PRKCD PRKCE PTK2B RDX RGS16 RIC8A S1PR2 S1PR3 S1PR4 TBXA2R TGFBR1 TSHR	7 interacting genes: CAV1 EDN1 EDN3 GNA11 GNA13 GRK6 NOS3
Entrez ID		10672	1910
HPRD ID		05100	08834
Ensembl ID		ENSG00000120063	ENSG00000136160
Uniprot IDs		Q14344	P24530
PDB IDs		7SF7 7SF8 7T6B 7YDH 8H8J 8KGG 8ZX4 8ZX5 9GE2 9GE3 9IY8 9IZH	5GLH 5GLI 5X93 5XPR 6IGK 6IGL 6LRY 8HBD 8HCX 8IY5 8IY6 8XGR 8XVE 8XVH 8XWP 8XWQ 8ZRT
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway Signal Transduction Plasma Membrane Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Membrane G Protein-coupled Receptor Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Cellular Response To Oxygen-containing Compound Intracellular Signal Transduction Rho-activating G Protein-coupled Receptor Signaling Pathway Intracellular Signaling Cassette G Protein-coupled Receptor Binding Sphingosine-1-phosphate Receptor Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Body Fluid Levels Positive Regulation Of Vasculature Development Peptidyl-serine Phosphorylation Positive Regulation Of Signal Transduction Modulation Of Chemical Synaptic Transmission Guanyl-nucleotide Exchange Factor Activity Sphingosine-1-phosphate Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Sphingolipid Mediated Signaling Pathway Diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Rho Protein Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Lipid Cell Motility Regulation Of Multicellular Organismal Process Regulation Of Blood Pressure Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Small GTPase Mediated Signal Transduction Regulation Of MAPK Cascade Catenin Complex Cell Surface Receptor Signaling Pathway Protein Kinase C Signaling Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity G-protein Alpha-subunit Binding Cell Migration Lamellipodium Regulation Of Protein Localization Regulation Of Vasculature Development Regulation Of Developmental Process Cellular Response To Indole-3-methanol	Regulation Of Systemic Arterial Blood Pressure By Endothelin Regulation Of Blood Pressure Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Blood Vessel Diameter Maintenance Vasoconstriction Regulation Of Tube Size Endothelin B Receptor Binding Regulation Of Systemic Arterial Blood Pressure Vein Smooth Muscle Contraction Regulation Of Heart Contraction Regulation Of Locomotion Regulation Of Smooth Muscle Contraction Regulation Of Vasoconstriction Regulation Of Muscle System Process Regulation Of The Force Of Heart Contraction By Chemical Signal Regulation Of Blood Circulation Regulation Of Blood Coagulation Vascular Process In Circulatory System Regulation Of Hemostasis Regulation Of Potassium Ion Transport Regulation Of Developmental Process Circulatory System Process Artery Smooth Muscle Contraction G Protein-coupled Receptor Signaling Pathway Tonic Smooth Muscle Contraction Regulation Of Heart Rate Endothelin Receptor Signaling Pathway Positive Regulation Of Cation Transmembrane Transport Positive Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transport Vascular Associated Smooth Muscle Contraction Guanyl Nucleotide Binding Regulation Of Wound Healing Regulation Of Cell Migration Positive Regulation Of Hormone Secretion Regulation Of Cell Motility Nitric Oxide Biosynthetic Process G-protein Beta/gamma-subunit Complex Binding Regulation Of Muscle Contraction Regulation Of Response To Wounding Regulation Of The Force Of Heart Contraction Positive Regulation Of Monoatomic Ion Transport Positive Regulation Of Cell Migration Regulation Of System Process Intracellular Calcium Ion Homeostasis Positive Regulation Of Heart Rate Negative Regulation Of Potassium Ion Transport Positive Regulation Of Cell Motility Nitric Oxide Metabolic Process Positive Regulation Of Smooth Muscle Contraction
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