MTNR1A and MYO9A

Number of citations of the paper that reports this interaction (PubMedID 26514267)
0

Data Source:
BioGRID (two hybrid)

		MTNR1A	MYO9A
Description		melatonin receptor 1A	myosin IXA
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Receptor Complex	Cytoplasm Cytosol Actin Filament Membrane Myosin Complex Unconventional Myosin Complex Growth Cone Cell Projection Axonal Growth Cone Synapse
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Melatonin Receptor Activity Hormone Binding	Microfilament Motor Activity Nucleotide Binding Cytoskeletal Motor Activity Actin Binding GTPase Activator Activity Protein Binding ATP Binding Zinc Ion Binding Metal Ion Binding Actin Filament Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Mating Behavior Circadian Rhythm	Signal Transduction Visual Perception Cell Junction Assembly Cell Junction Organization Intracellular Signal Transduction Establishment Of Epithelial Cell Apical/basal Polarity Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Neuron Projection Arborization
Pathways		Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events	RHOA GTPase cycle RHOB GTPase cycle RHOV GTPase cycle
Drugs		Ramelteon Melatonin Resveratrol Agomelatine Tasimelteon
Diseases
GWAS		Depressive symptoms measurement (somatic complaints domain) ( 26997408) Job-related exhaustion in shift workers ( 28364478) Mild obesity-related type 2 diabetes ( 34737425) Obesity ( 21552555)	Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 20881960) Macular thickness ( 30535121) Metabolite levels (HVA/MHPG ratio) ( 23319000) Rate of cognitive decline in mild cognitive impairment (time interaction) ( 22833209) Red blood cell count ( 27863252) Serum uric acid levels ( 30993211) Triglyceride levels ( 30108155 32203549) Urate levels ( 31578528)
Interacting Genes		160 interacting genes: ABHD14B ACTB ACTN1 AMOTL2 ANKRD12 ARHGAP28 ASAP3 ASCL1 ATIC ATP5MC3 BAG6 BAZ1A BAZ1B C10orf90 CALR CAND1 CANX CCDC167 CD99 CHD4 CIAO2B CIT CLASP1 CMIP CNP COG1 COL9A2 COMT COX11 CTNNA1 CTPS2 CUL3 CUL7 CYP27C1 CYSRT1 DDHD2 DDX52 DPM1 ECE1 ECE2 EEF1G EMC7 EMD ENO2 EPS15 EXOC1 F8A1 FAM241B FDXR FLNA FN1 FSTL1 GALNS GAPDH GATAD2B GBA2 GEMIN2 GFPT2 GNA11 GNA13 GNAI1 GNAI2 GNAI3 GNB1 GNB4 GPR50 H2AC6 HDAC10 HIVEP2 HMGN2 HMOX2 HNRNPA0 HNRNPH1 HSPA5 IPO9 IRS4 ITPR3 KLHL12 KLHL20 KLHL5 KPNB1 KRTAP1-3 KRTAP10-8 LAPTM4A LIPE LPP LRP3 LRRC59 MAMLD1 MCC MESD MMP2 MMS19 MPDZ MTNR1B MYO9A NAP1L1 NAP1L4 NAP1L5 NASP PAXIP1 PCDHB10 PDIA6 PEX14 PGRMC1 PKD1L2 PPP2R3C PRELID1 PSMD2 PSME4 PTPN13 PTPRD PTX3 RAB10 RAC1 RACK1 RAP1A RBM39 RGS12 RNF2 RNF41 RPL3 RTRAF SLC2A3 SLC30A1 SLC6A3 SLIT1 SNAPIN SOX11 SRI STXBP1 SUCLA2 SURF4 SVEP1 TLN1 TM9SF1 TMEM14A TMEM230 TMEM33 TMX2 TPP2 TRIP12 TUBB TVP23B UBA1 UBAP2L UBQLN1 UBR4 USP28 USP32 USP34 VAPB VARS1 WAPL WASHC4 YWHAB YWHAZ ZC3H11A ZDHHC16 ZNF460	5 interacting genes: CDC42 ERBB2 MTNR1A POLR2M RHOA
Entrez ID		4543	4649
HPRD ID		02812	05341
Ensembl ID		ENSG00000168412	ENSG00000066933
Uniprot IDs		P48039	B2RTY4
PDB IDs		6ME2 6ME3 6ME4 6ME5 7DB6 7VGY 7VGZ
Enriched GO Terms of Interacting Partners?		Extracellular Exosome Cytosol Heterotrimeric G-protein Complex Focal Adhesion Melanosome Guanyl Nucleotide Binding Membrane G-protein Beta/gamma-subunit Complex Binding Cadherin Binding Homotypic Cell-cell Adhesion Regulation Of Organelle Organization Proteasomal Protein Catabolic Process G Protein Activity Regulation Of Cellular Component Organization Cytoplasm G Protein-coupled Receptor Binding Platelet Aggregation Diacylglycerol Lipase Activity Protein Binding Vinculin Binding Cellular Localization Protein Folding In Endoplasmic Reticulum Regulation Of Biological Quality Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process GTPase Activity Negative Regulation Of Vasoconstriction Proteolysis Neural Nucleus Development Establishment Of Protein Localization Protein Metabolic Process Negative Regulation Of Synapse Organization Cullin-RING Ubiquitin Ligase Complex Nucleoplasm Nucleosomal DNA Binding Protein-containing Complex Binding Melatonin Receptor Activity	Establishment Of Apical/basal Cell Polarity Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Polarized Epithelial Cell Differentiation Establishment Of Epithelial Cell Apical/basal Polarity Establishment Of Epithelial Cell Polarity Wnt Signaling Pathway, Planar Cell Polarity Pathway Substantia Nigra Development Establishment Or Maintenance Of Apical/basal Cell Polarity Semaphorin-plexin Signaling Pathway Positive Regulation Of Stress Fiber Assembly Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Cytokinesis Membrane Invagination Non-canonical Wnt Signaling Pathway Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Actin Filament Bundle Assembly Neural Nucleus Development G Protein Activity Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Cell Junction Organization Mitotic Cleavage Furrow Formation Regulation Of Cytokinesis Collagen Type XV Trimer Maintenance Of ER Location Positive Regulation Of Cell Division Establishment Of Cell Polarity Cell Periphery Positive Regulation Of Cell Adhesion Regulation Of Stress Fiber Assembly Ruffle Membrane Aortic Valve Formation Positive Regulation Of Vascular Associated Smooth Muscle Contraction Endothelial Tube Lumen Extension Glial Cell Differentiation Skeletal Muscle Satellite Cell Migration GBD Domain Binding Storage Vacuole ERBB3:ERBB2 Complex Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Kinase Activity Striated Muscle Tissue Development Positive Regulation Of Kinase Activity Beta Selection Endothelin Receptor Signaling Pathway Involved In Heart Process RNA Polymerase I Core Binding Muscle Tissue Development Bone Trabecula Morphogenesis Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Cell Growth
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