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MTNR1A and GNAI1
Number of citations of the paper that reports this interaction (PMID
17215244
)
14
Data Source:
HPRD
(in vivo)
MTNR1A
GNAI1
Gene Name
melatonin receptor 1A
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
Receptor Complex
Nucleus
Cytoplasm
Lysosomal Membrane
Centrosome
Heterotrimeric G-protein Complex
Plasma Membrane
Midbody
Extracellular Vesicular Exosome
Molecular Function
Protein Binding
Melatonin Receptor Activity
Hormone Binding
Organic Cyclic Compound Binding
GTPase Activity
Signal Transducer Activity
Protein Binding
GTP Binding
G-protein Beta/gamma-subunit Complex Binding
G-protein Coupled Serotonin Receptor Binding
Metal Ion Binding
Biological Process
G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Mating Behavior
Circadian Rhythm
Positive Regulation Of CGMP Biosynthetic Process
Cell Cycle
G-protein Coupled Receptor Signaling Pathway
Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway
Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway
Synaptic Transmission
Blood Coagulation
Platelet Activation
Response To Peptide Hormone
Cell Division
Pathways
Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
Signaling by GPCR
GPCR downstream signaling
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
Metabolic disorders of biological oxidation enzymes
GPCR ligand binding
Signaling by GPCR
Integration of energy metabolism
G alpha (s) signalling events
Activation of GABAB receptors
Signal amplification
G alpha (z) signalling events
G alpha (i) signalling events
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
ADP signalling through P2Y purinoceptor 12
GABA B receptor activation
Adenylate cyclase inhibitory pathway
GABA receptor activation
PLC beta mediated events
Opioid Signalling
Regulation of insulin secretion
G-protein mediated events
Adrenaline,noradrenaline inhibits insulin secretion
Inhibition of adenylate cyclase pathway
Adenylate cyclase inhibitory pathway
GPCR downstream signaling
G-protein activation
Platelet activation, signaling and aggregation
Transmission across Chemical Synapses
Drugs
Ramelteon
Melatonin
Agomelatine
Diseases
GWAS
Obesity (
21552555
)
Protein-Protein Interactions
26 interactors:
CALR
CANX
CNP
DPM1
EEF1G
FLNA
GNA11
GNA13
GNAI1
GNAI2
GNAI3
GNB1
GNB4
GPR50
HNRNPA0
HSPA5
IRS4
LRRC59
MTNR1B
PDIA6
PGRMC1
RAB10
RAC1
RAP1A
TMEM33
VAPB
57 interactors:
ADCY5
ADRA2A
CCR5
CD47
CNR1
CRHR1
CXCR4
DRD3
EPOR
ESR1
FFAR1
GNAO1
GNB2
GNB4
GPR1
GPR143
GPSM1
GPSM2
GPSM3
HRH4
HTR2A
IGF1R
KLHL3
MTNR1A
MTNR1B
NGB
NUCB1
NUMA1
OPRD1
OPRM1
PDE6D
PTPRU
RANGAP1
RASD1
RGS10
RGS12
RGS14
RGS16
RGS17
RGS18
RGS19
RGS20
RGS4
RGS7
RIC8A
S1PR1
S1PR2
S1PR3
S1PR4
S1PR5
SSTR2
SSTR3
STRN
THAP7
TSHR
VIPR1
WASF1
Entrez ID
4543
2770
HPRD ID
02812
00756
Ensembl ID
ENSG00000168412
ENSG00000127955
Uniprot IDs
P48039
P63096
PDB IDs
1KJY
1Y3A
2G83
2GTP
2IK8
2OM2
2PZ3
2XNS
3ONW
3QE0
3QI2
3UMR
3UMS
4G5Q
Enriched GO Terms of Interacting Partners
?
Platelet Activation
G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Blood Coagulation
Hemostasis
Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway
Regulation Of Body Fluid Levels
Wound Healing
Cell Activation
Response To Wounding
Signaling
Cell Communication
Response To Stimulus
G-protein Coupled Receptor Signaling Pathway
Signal Transduction
Activation Of Signaling Protein Activity Involved In Unfolded Protein Response
Response To Organic Substance
Positive Regulation Of Nuclease Activity
Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway
Positive Regulation Of Kinase Activity
Vesicle-mediated Transport
Positive Regulation Of Transferase Activity
Response To Stress
Synaptic Transmission
Cell-cell Signaling
Endoplasmic Reticulum Unfolded Protein Response
Cellular Response To Unfolded Protein
ER-nucleus Signaling Pathway
Cellular Response To Stimulus
Cellular Response To Topologically Incorrect Protein
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Kinase Activity
Dopamine Receptor Signaling Pathway
Substantia Nigra Development
Cellular Response To Organic Substance
Response To Unfolded Protein
Regulation Of Kinase Activity
Membrane Organization
Positive Regulation Of Phosphorylation
Response To Endoplasmic Reticulum Stress
Cell Surface Receptor Signaling Pathway
Neural Nucleus Development
Positive Regulation Of Protein Modification Process
Ras Protein Signal Transduction
Regulation Of Protein Phosphorylation
Regulation Of Phosphorus Metabolic Process
Regulation Of Protein Kinase Activity
Response To Peptide Hormone
Midbrain Development
G-protein Coupled Acetylcholine Receptor Signaling Pathway
Positive Regulation Of Cellular Protein Metabolic Process
G-protein Coupled Receptor Signaling Pathway
G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Cell Surface Receptor Signaling Pathway
Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway
Regulation Of G-protein Coupled Receptor Protein Signaling Pathway
Signal Transduction
Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway
Signaling
Cell Communication
Regulation Of Catalytic Activity
Termination Of G-protein Coupled Receptor Signaling Pathway
Termination Of Signal Transduction
Cellular Response To Stimulus
Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway
Positive Regulation Of Catalytic Activity
Response To Stimulus
Regulation Of Signaling
Positive Regulation Of Hydrolase Activity
Positive Regulation Of Cytosolic Calcium Ion Concentration
Sphingosine-1-phosphate Signaling Pathway
Regulation Of Cellular Process
Chemical Homeostasis
Cell-cell Signaling
Cytosolic Calcium Ion Homeostasis
Positive Regulation Of GTPase Activity
Cellular Calcium Ion Homeostasis
Calcium Ion Homeostasis
Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway
Regulation Of GTPase Activity
Positive Regulation Of Metabolic Process
Regulation Of Signal Transduction
Synaptic Transmission
Negative Regulation Of Signaling
Behavior
Cellular Metal Ion Homeostasis
Neuropeptide Signaling Pathway
Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway
Cellular Cation Homeostasis
Ion Homeostasis
Cellular Ion Homeostasis
Homeostatic Process
Metal Ion Homeostasis
Negative Regulation Of Signal Transduction
Cellular Chemical Homeostasis
Locomotory Behavior
Response To Ammonium Ion
Negative Regulation Of Ion Transport
Response To Cocaine
Regulation Of Cell Proliferation
Neurological System Process
Tagcloud
?
alkenes
azotic
constructions
gnao1
heterocycle
hm
hms
htr1b
htr2a
htr2b
htr4
htr6
htr7
kpnb1
pharmacopeia
prkaca
prkca
prkcb
prkcd
prkce
prkcg
prkd1
propertied
pubchem
rock2
rps6ka1
rps6ka3
tlr8
tradition
Tagcloud (Difference)
?
alkenes
azotic
constructions
gnao1
heterocycle
hm
hms
htr1b
htr2a
htr2b
htr4
htr6
htr7
kpnb1
pharmacopeia
prkaca
prkca
prkcb
prkcd
prkce
prkcg
prkd1
propertied
pubchem
rock2
rps6ka1
rps6ka3
tlr8
tradition
Tagcloud (Intersection)
?