GNA13 and S1PR4

Number of citations of the paper that reports this interaction (PubMedID 12767884)
0

Data Source:
HPRD (in vitro)

		GNA13	S1PR4
Description		G protein subunit alpha 13	sphingosine-1-phosphate receptor 4
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Heterotrimeric G-protein Complex Plasma Membrane Focal Adhesion Membrane Brush Border Membrane Melanosome Extracellular Exosome Postsynapse	Cytoplasm Mitochondrion Plasma Membrane Membrane Presynapse
	Molecular Function	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity G Protein Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding D5 Dopamine Receptor Binding Metal Ion Binding	G Protein-coupled Receptor Activity Protein Binding Lipid Binding Sphingosine-1-phosphate Receptor Activity
	Biological Process	Angiogenesis Branching Involved In Blood Vessel Morphogenesis In Utero Embryonic Development Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Regulation Of Blood Pressure Regulation Of Cell Shape Regulation Of Fibroblast Migration Cell Differentiation Platelet Activation Intracellular Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Postsynapse Assembly Rho-activating G Protein-coupled Receptor Signaling Pathway	Sphingosine-1-phosphate Receptor Signaling Pathway Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events Thromboxane signalling through TP receptor Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) CDC42 GTPase cycle RAC1 GTPase cycle	G alpha (i) signalling events Lysosphingolipid and LPA receptors
Drugs			Fingolimod
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Periventricular white matter hyperintensities ( 32517579) White matter microstructure (global fractional anisotropy) ( 24736177)	Asthma ( 31959851) Basophil percentage of granulocytes ( 27863252) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 27863252) Mean platelet volume ( 32888494) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Plateletcrit ( 32888494) Reticulocyte fraction of red cells ( 32888494) Sum basophil neutrophil counts ( 27863252) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 32888494 29403010 27863252)
Interacting Genes		31 interacting genes: AIP AKAP3 ARHGEF1 ARHGEF11 ARHGEF12 CDH1 CDH2 CTNNB1 CXCR4 DRD5 EDNRB F2R GNA12 GPR17 MCF2 MTNR1A PPP5C PRKACA PRKCB PRKCD PRKCE PTK2B RDX RGS16 RIC8A S1PR2 S1PR3 S1PR4 TBXA2R TGFBR1 TSHR	4 interacting genes: GEMIN4 GNA12 GNA13 GNAI1
Entrez ID		10672	8698
HPRD ID		05100	04779
Ensembl ID		ENSG00000120063	ENSG00000125910
Uniprot IDs		Q14344	O95977
PDB IDs		7SF7 7SF8 7T6B 7YDH 8H8J 8KGG 8ZX4 8ZX5 9GE2 9GE3 9IY8 9IZH	2DCO
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway Signal Transduction Plasma Membrane Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Membrane G Protein-coupled Receptor Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Cellular Response To Oxygen-containing Compound Intracellular Signal Transduction Rho-activating G Protein-coupled Receptor Signaling Pathway Intracellular Signaling Cassette G Protein-coupled Receptor Binding Sphingosine-1-phosphate Receptor Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Body Fluid Levels Positive Regulation Of Vasculature Development Peptidyl-serine Phosphorylation Positive Regulation Of Signal Transduction Modulation Of Chemical Synaptic Transmission Guanyl-nucleotide Exchange Factor Activity Sphingosine-1-phosphate Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Sphingolipid Mediated Signaling Pathway Diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Rho Protein Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Lipid Cell Motility Regulation Of Multicellular Organismal Process Regulation Of Blood Pressure Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Small GTPase Mediated Signal Transduction Regulation Of MAPK Cascade Catenin Complex Cell Surface Receptor Signaling Pathway Protein Kinase C Signaling Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity G-protein Alpha-subunit Binding Cell Migration Lamellipodium Regulation Of Protein Localization Regulation Of Vasculature Development Regulation Of Developmental Process Cellular Response To Indole-3-methanol	Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding D5 Dopamine Receptor Binding Heterotrimeric G-protein Complex G Protein-coupled Receptor Binding G Protein Activity Rho-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway T Cell Migration Regulation Of Fibroblast Migration GTPase Activity Brush Border Membrane GTP Binding Lymphocyte Migration Rho Protein Signal Transduction Mononuclear Cell Migration Regulation Of Cell Shape G Protein-coupled Receptor Signaling Pathway D2 Dopamine Receptor Binding Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Relaxation Of Smooth Muscle G Protein-coupled Serotonin Receptor Binding Regulation Of Blood Pressure Adenylate Cyclase Inhibitor Activity Adenylate Cyclase Regulator Activity Regulation Of Cell Migration Leukocyte Migration Positive Regulation Of Protein Localization To Cell Cortex Regulation Of Cell Motility Regulation Of Cell Morphogenesis In Utero Embryonic Development Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Regulation Of Locomotion Small GTPase-mediated Signal Transduction Regulation Of Protein Localization To Cell Cortex Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway SMN Complex Gemini Of Cajal Bodies Cellular Response To Forskolin Regulation Of Relaxation Of Muscle T Cell Chemotaxis Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Positive Regulation Of T Cell Chemotaxis Regulation Of T Cell Chemotaxis Positive Regulation Of Myoblast Fusion Small Nuclear Ribonucleoprotein Complex Response To Forskolin SMN-Sm Protein Complex
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