MTNR1A and KLHL5

Number of citations of the paper that reports this interaction (PubMedID 26514267)
0

Data Source:
BioGRID (two hybrid)

		MTNR1A	KLHL5
Description		melatonin receptor 1A	kelch like family member 5
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Receptor Complex	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Microtubule Cytoskeleton Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Melatonin Receptor Activity Hormone Binding	Actin Binding Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Mating Behavior Circadian Rhythm	Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Ramelteon Melatonin Resveratrol Agomelatine Tasimelteon
Diseases
GWAS		Depressive symptoms measurement (somatic complaints domain) ( 26997408) Job-related exhaustion in shift workers ( 28364478) Mild obesity-related type 2 diabetes ( 34737425) Obesity ( 21552555)	Asthma (childhood onset) ( 23829686)
Interacting Genes		160 interacting genes: ABHD14B ACTB ACTN1 AMOTL2 ANKRD12 ARHGAP28 ASAP3 ASCL1 ATIC ATP5MC3 BAG6 BAZ1A BAZ1B C10orf90 CALR CAND1 CANX CCDC167 CD99 CHD4 CIAO2B CIT CLASP1 CMIP CNP COG1 COL9A2 COMT COX11 CTNNA1 CTPS2 CUL3 CUL7 CYP27C1 CYSRT1 DDHD2 DDX52 DPM1 ECE1 ECE2 EEF1G EMC7 EMD ENO2 EPS15 EXOC1 F8A1 FAM241B FDXR FLNA FN1 FSTL1 GALNS GAPDH GATAD2B GBA2 GEMIN2 GFPT2 GNA11 GNA13 GNAI1 GNAI2 GNAI3 GNB1 GNB4 GPR50 H2AC6 HDAC10 HIVEP2 HMGN2 HMOX2 HNRNPA0 HNRNPH1 HSPA5 IPO9 IRS4 ITPR3 KLHL12 KLHL20 KLHL5 KPNB1 KRTAP1-3 KRTAP10-8 LAPTM4A LIPE LPP LRP3 LRRC59 MAMLD1 MCC MESD MMP2 MMS19 MPDZ MTNR1B MYO9A NAP1L1 NAP1L4 NAP1L5 NASP PAXIP1 PCDHB10 PDIA6 PEX14 PGRMC1 PKD1L2 PPP2R3C PRELID1 PSMD2 PSME4 PTPN13 PTPRD PTX3 RAB10 RAC1 RACK1 RAP1A RBM39 RGS12 RNF2 RNF41 RPL3 RTRAF SLC2A3 SLC30A1 SLC6A3 SLIT1 SNAPIN SOX11 SRI STXBP1 SUCLA2 SURF4 SVEP1 TLN1 TM9SF1 TMEM14A TMEM230 TMEM33 TMX2 TPP2 TRIP12 TUBB TVP23B UBA1 UBAP2L UBQLN1 UBR4 USP28 USP32 USP34 VAPB VARS1 WAPL WASHC4 YWHAB YWHAZ ZC3H11A ZDHHC16 ZNF460	6 interacting genes: GABARAPL2 MAP1LC3B MTNR1A SMN1 TK1 USP7
Entrez ID		4543	51088
HPRD ID		02812	10477
Ensembl ID		ENSG00000168412	ENSG00000109790
Uniprot IDs		P48039	A0A804C9D6 Q59HD9 Q7Z6D5 Q96PQ7
PDB IDs		6ME2 6ME3 6ME4 6ME5 7DB6 7VGY 7VGZ
Enriched GO Terms of Interacting Partners?		Extracellular Exosome Cytosol Heterotrimeric G-protein Complex Focal Adhesion Melanosome Guanyl Nucleotide Binding Membrane G-protein Beta/gamma-subunit Complex Binding Cadherin Binding Homotypic Cell-cell Adhesion Regulation Of Organelle Organization Proteasomal Protein Catabolic Process G Protein Activity Regulation Of Cellular Component Organization Cytoplasm G Protein-coupled Receptor Binding Platelet Aggregation Diacylglycerol Lipase Activity Protein Binding Vinculin Binding Cellular Localization Protein Folding In Endoplasmic Reticulum Regulation Of Biological Quality Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process GTPase Activity Negative Regulation Of Vasoconstriction Proteolysis Neural Nucleus Development Establishment Of Protein Localization Protein Metabolic Process Negative Regulation Of Synapse Organization Cullin-RING Ubiquitin Ligase Complex Nucleoplasm Nucleosomal DNA Binding Protein-containing Complex Binding Melatonin Receptor Activity	Autophagosome Organization Autophagosome Assembly Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Vacuole Organization Cellular Response To Nutrient Levels Autophagosome Maturation Autophagosome Membrane Mitophagy Negative Regulation Of Proteasomal Protein Catabolic Process Cellular Component Assembly Autophagy Of Mitochondrion Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Autophagosome Response To Nutrient Levels Protein-containing Complex Organization Thymidine Kinase Activity Negative Regulation Of Protein Catabolic Process Phospholipid Binding DNA Synthesis Involved In Mitotic DNA Replication Negative Regulation Of Proteolysis Symbiont-mediated Disruption Of Host Cell PML Body Protein-containing Complex Disassembly Melatonin Receptor Activity Organelle Assembly Macroautophagy Thymidine Biosynthetic Process Cellular Response To Starvation Regulation Of Proteasomal Protein Catabolic Process Thymidine Metabolic Process Regulation Of Establishment Of Protein Localization To Chromosome Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Retrograde Transport, Endosome To Golgi Response To Starvation Rhythmic Process Deoxyribonucleoside Monophosphate Biosynthetic Process Monoubiquitinated Protein Deubiquitination Microtubule Binding Ceramide Binding SMN Complex DNA Alkylation Repair Gemini Of Cajal Bodies Pyrimidine Nucleoside Metabolic Process Transcription-coupled Nucleotide-excision Repair Autophagy Ubiquitin Protein Ligase Binding Regulation Of Telomere Capping Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Hormone Binding SMN-Sm Protein Complex
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