MTNR1A and DPM1

Number of citations of the paper that reports this interaction (PMID 17215244)
14

Data Source:
HPRD (in vitro)

		MTNR1A	DPM1
Gene Name		melatonin receptor 1A	dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Dolichol-phosphate-mannose Synthase Complex
	Molecular Function	Protein Binding Melatonin Receptor Activity Hormone Binding Organic Cyclic Compound Binding	Dolichyl-phosphate-mannose-protein Mannosyltransferase Activity Dolichyl-phosphate Beta-D-mannosyltransferase Activity Protein Binding Mannose Binding Alcohol Binding
	Biological Process	G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Mating Behavior Circadian Rhythm Positive Regulation Of CGMP Biosynthetic Process	Dolichol-linked Oligosaccharide Biosynthetic Process C-terminal Protein Lipidation GPI Anchor Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Dolichol Metabolic Process GDP-mannose Metabolic Process Protein Mannosylation Protein O-linked Mannosylation Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Diseases of glycosylation Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective MOGS causes MOGS-CDG (CDG-2b) Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG9 causes ALG9-CDG (CDG-1l) Synthesis of dolichyl-phosphate mannose Defective MAN1B1 causes MRT15 Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Synthesis of substrates in N-glycan biosythesis Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Post-translational modification: synthesis of GPI-anchored proteins Defective ALG6 causes ALG6-CDG (CDG-1c) Defective RFT1 causes RFT1-CDG (CDG-1n) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Synthesis of dolichyl-phosphate mannose Diseases associated with N-glycosylation of proteins
Drugs		Ramelteon Melatonin Agomelatine
Diseases
GWAS		Obesity ( 21552555)
Protein-Protein Interactions		26 interactors: CALR CANX CNP DPM1 EEF1G FLNA GNA11 GNA13 GNAI1 GNAI2 GNAI3 GNB1 GNB4 GPR50 HNRNPA0 HSPA5 IRS4 LRRC59 MTNR1B PDIA6 PGRMC1 RAB10 RAC1 RAP1A TMEM33 VAPB	5 interactors: DPM2 DPM3 MTNR1A TDO2 ZBTB16
Entrez ID		4543	8813
HPRD ID		02812	04613
Ensembl ID		ENSG00000168412	ENSG00000000419
Uniprot IDs		P48039	O60762 Q5QPK2
PDB IDs
Enriched GO Terms of Interacting Partners?		Platelet Activation G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Blood Coagulation Hemostasis Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Body Fluid Levels Wound Healing Cell Activation Response To Wounding Signaling Cell Communication Response To Stimulus G-protein Coupled Receptor Signaling Pathway Signal Transduction Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Response To Organic Substance Positive Regulation Of Nuclease Activity Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Kinase Activity Vesicle-mediated Transport Positive Regulation Of Transferase Activity Response To Stress Synaptic Transmission Cell-cell Signaling Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein ER-nucleus Signaling Pathway Cellular Response To Stimulus Cellular Response To Topologically Incorrect Protein Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Kinase Activity Dopamine Receptor Signaling Pathway Substantia Nigra Development Cellular Response To Organic Substance Response To Unfolded Protein Regulation Of Kinase Activity Membrane Organization Positive Regulation Of Phosphorylation Response To Endoplasmic Reticulum Stress Cell Surface Receptor Signaling Pathway Neural Nucleus Development Positive Regulation Of Protein Modification Process Ras Protein Signal Transduction Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Response To Peptide Hormone Midbrain Development G-protein Coupled Acetylcholine Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process	Protein O-linked Mannosylation Protein Mannosylation C-terminal Protein Lipidation Mannosylation Dolichol-linked Oligosaccharide Biosynthetic Process GPI Anchor Biosynthetic Process GPI Anchor Metabolic Process Glycolipid Biosynthetic Process Protein O-linked Glycosylation Protein N-linked Glycosylation Via Asparagine Protein Lipidation Lipoprotein Biosynthetic Process Protein N-linked Glycosylation Phosphatidylinositol Biosynthetic Process Glycolipid Metabolic Process Regulation Of Protein Stability Tryptophan Catabolic Process To Acetyl-CoA Lipoprotein Metabolic Process Glycerophospholipid Biosynthetic Process Post-translational Protein Modification Dolichol Metabolic Process Phosphatidylinositol Metabolic Process Membrane Lipid Metabolic Process Positive Regulation Of NK T Cell Differentiation Protein C-linked Glycosylation Via 2'-alpha-mannosyl-L-tryptophan Phospholipid Biosynthetic Process Male Germ-line Stem Cell Asymmetric Division Glycerophospholipid Metabolic Process Macromolecule Glycosylation Protein Glycosylation Tryptophan Catabolic Process To Kynurenine Glycosylation Kynurenine Metabolic Process Glycerolipid Metabolic Process Phospholipid Metabolic Process Glycoprotein Biosynthetic Process Preassembly Of GPI Anchor In ER Membrane Glycoprotein Metabolic Process Tryptophan Catabolic Process Posttranscriptional Regulation Of Gene Expression Positive Regulation Of CGMP Biosynthetic Process Tryptophan Metabolic Process Positive Regulation Of CGMP Metabolic Process Acetyl-CoA Metabolic Process Regulation Of CGMP Biosynthetic Process Lipid Biosynthetic Process Positive Regulation Of Chondrocyte Differentiation Regulation Of CGMP Metabolic Process Mating Behavior Stem Cell Division
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