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ALAS1 and TK1
Number of citations of the paper that reports this interaction (PubMedID
21900206
)
0
Data Source:
BioGRID
(two hybrid)
ALAS1
TK1
Description
5'-aminolevulinate synthase 1
thymidine kinase 1
Image
No pdb structure
GO Annotations
Cellular Component
Nucleoplasm
Mitochondrion
Mitochondrial Inner Membrane
Mitochondrial Matrix
Cytosol
Membrane
Nucleus
Cytoplasm
Cytosol
Molecular Function
5-aminolevulinate Synthase Activity
Protein Binding
Transferase Activity
Acyltransferase Activity
Pyridoxal Phosphate Binding
Identical Protein Binding
Nucleotide Binding
Thymidine Kinase Activity
Protein Binding
ATP Binding
Zinc Ion Binding
Kinase Activity
Transferase Activity
Identical Protein Binding
Metal Ion Binding
Biological Process
Response To Hypoxia
Porphyrin-containing Compound Metabolic Process
Protoporphyrinogen IX Biosynthetic Process
Heme Biosynthetic Process
Heme A Biosynthetic Process
Heme B Biosynthetic Process
Response To Xenobiotic Stimulus
Response To Herbicide
Response To Nickel Cation
Response To Nutrient Levels
Response To Cobalt Ion
Cellular Response To Insulin Stimulus
Tetrapyrrole Biosynthetic Process
Response To Gonadotropin
Hemoglobin Biosynthetic Process
Response To Ethanol
Heme O Biosynthetic Process
Erythrocyte Development
Response To CAMP
Response To Platinum Ion
Response To Bile Acid
Nucleobase-containing Compound Metabolic Process
Deoxyribonucleoside Monophosphate Biosynthetic Process
Thymidine Metabolic Process
Thymidine Biosynthetic Process
Protein Homotetramerization
DNA Biosynthetic Process
DNA Synthesis Involved In Mitotic DNA Replication
Pathways
Heme biosynthesis
PPARA activates gene expression
Transcriptional activation of mitochondrial biogenesis
Mitochondrial protein degradation
G1/S-Specific Transcription
Pyrimidine salvage
Drugs
Pyridoxal phosphate
Pyridoxal phosphate
Glycine
Dithioerythritol
Thymidine 5'-triphosphate
Diseases
GWAS
Autism spectrum disorder or schizophrenia (
28540026
)
Bipolar disorder (
21926972
)
Parkinson's disease (
28892059
)
Schizophrenia (
23974872
)
Gut microbiota (bacterial taxa, hurdle binary method) (
32572223
)
Leukocyte telomere length (
32109421
)
Mean corpuscular hemoglobin (
27863252
32888494
)
Mean corpuscular volume (
27863252
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Red cell distribution width (
27863252
28957414
32888494
)
Interacting Genes
54 interacting genes:
BCL7A
C2orf42
C8orf33
CAP2
CCHCR1
CDC73
CDK5
CDKN1A
CERK
COBL
EP400
FBXL8
FXR1
GNL3L
GRXCR1
HSBP1L1
JRK
KIF9
KLHL35
LONRF1
LRRC45
MTFR2
MTSS2
NUDT3
OXTR
PIBF1
PIK3CB
PLAU
POLDIP2
PPL
RAP1B
RNF168
RTL8B
SH2D4A
SNRPB2
SNX20
STAMBP
SUMO2
TCEA2
TEKT4
TK1
TMSB10
TMSB4X
TMSB4XP1
TMSB4XP2
TMSB4XP6
TTC23
USP20
UTP14C
WIPF1
ZFYVE26
ZMAT1
ZNF175
ZNF564
166 interacting genes:
A1BG
A2M
AAMP
ABHD4
ACTB
ACTL6B
ACTR1B
ADAMTS10
ADD1
AGAP1
ALAS1
ALB
APLP1
APP
ARFGAP1
ATG16L2
ATP5F1B
ATP6V1A
ATXN3
BAG6
BOLA2
BOLA2B
CARHSP1
CCDC90B
CDC20
CDK1
CDK4
CDKN1A
CENPB
CFTR
CHGB
CLEC3B
COL11A2
COL4A2
COL4A5
COPS6
CPNE6
CRIP2
CRMP1
CSAD
DACT1
DALRD3
DCAF13
DDAH2
DEAF1
DMPK
DOCK7
DRAP1
DUS2
DYNC1I1
DYNC2I1
DYNLT2B
EEF1A1
EIF3G
EIF4A2
EIF6
ERG28
EXT2
EZH2
F13A1
FAF1
FAM20C
FBN3
FGB
FLAD1
FST
FZR1
GAPDH
GDF9
GDI1
GET3
GLB1
GPCPD1
HADHB
HERC3
HMGXB3
HSPBAP1
IER3IP1
IGHM
IMMT
INPP5K
INTS11
ITSN1
JADE1
JMJD1C
KDM6B
KIF21B
KIF5A
KLHL23
KLHL5
KMT2B
LRIF1
MAGEA4
MAST2
MED31
METTL23
MKI67
MPP1
MPPED1
MRFAP1
MRPL20-AS1
MRPL37
MSH2
NEUROD2
NGFR
NKIRAS2
NMT2
NRBP1
ODC1
PAAF1
PDE4DIP
PJA1
PKM
PLD3
PLXNA3
PPP4C
PRMT1
PROC
PSME1
PTPN4
PTPRK
QARS1
RBBP4
RBM48
REX1BD
RPA1
RPL13
RPS2
RUVBL1
RXRA
SDF4
SEMA5B
SEPTIN6
SETDB1
SEZ6L2
SMC5
SNX1
SP110
SULT1A3
SUMO2
SUMO3
TAF1C
THOC3
TIAM2
TLE1
TMSB4X
TP53
TRIM46
TRMT2A
TSC2
TTC38
TUBA1A
TUBB2A
TUBB3
TYK2
UBC
UNC119
UPF2
USP4
VMA22
WDR18
WDR73
WIZ
ZBTB16
ZNF431
ZXDC
Entrez ID
211
7083
HPRD ID
00505
01771
Ensembl ID
ENSG00000023330
ENSG00000167900
Uniprot IDs
B4DVA0
P13196
Q5JAM2
A0A384MDV9
K7ERV3
K7ES52
P04183
PDB IDs
1W4R
1XBT
2ORV
2WVJ
Enriched GO Terms of Interacting Partners
?
Actin Monomer Binding
Cytoplasm
Macromolecule Metabolic Process
Protein Metabolic Process
Platelet Alpha Granule Lumen
Chromatin Organization
Blood Microparticle
Negative Regulation Of Cell Cycle G1/S Phase Transition
Chromatin Remodeling
Regulation Of Cell Cycle G1/S Phase Transition
Negative Regulation Of Cell Cycle Phase Transition
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Cell Cycle Phase Transition
Regulation Of Mitotic Cell Cycle
Extracellular Exosome
Cytosol
Regulation Of DNA Replication
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Protein Binding
Nucleoplasm
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Mitotic Cell Cycle Phase Transition
Negative Regulation Of Mitotic Cell Cycle
Positive Regulation Of Ubiquitin-protein Transferase Activity
Nuclear Matrix
Regulation Of Protein Catabolic Process
DNA Synthesis Involved In Mitotic DNA Replication
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Macromolecule Biosynthetic Process
Chromosome, Telomeric Region
Positive Regulation Of Protein Metabolic Process
Cytoskeleton
Negative Regulation Of Cell Cycle Process
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Protein Tag Activity
Developmental Process
Growth Cone
Protein Modification Process
Cellular Response To Norepinephrine Stimulus
Response To Norepinephrine
Mitotic DNA Damage Checkpoint Signaling
Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process
Oocyte Growth
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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