TK1 and COL11A2

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		TK1	COL11A2
Description		thymidine kinase 1	collagen type XI alpha 2 chain
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Extracellular Region Collagen Trimer Collagen Type II Trimer Collagen Type XI Trimer Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	Nucleotide Binding Thymidine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Identical Protein Binding Metal Ion Binding	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Protein-macromolecule Adaptor Activity Metal Ion Binding
	Biological Process	Nucleobase-containing Compound Metabolic Process Deoxyribonucleoside Monophosphate Biosynthetic Process Thymidine Metabolic Process Thymidine Biosynthetic Process Protein Homotetramerization DNA Biosynthetic Process DNA Synthesis Involved In Mitotic DNA Replication	Skeletal System Development Sensory Perception Of Sound Collagen Fibril Organization Cartilage Development Roof Of Mouth Development Soft Palate Development
Pathways		G1/S-Specific Transcription Pyrimidine salvage	Collagen degradation Collagen degradation Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Non-integrin membrane-ECM interactions MET activates PTK2 signaling Collagen chain trimerization Developmental Lineage of Pancreatic Ductal Cells
Drugs		Dithioerythritol Thymidine 5'-triphosphate
Diseases			Deafness, autosomal recessive Type XI collagenopathies, including: Stickler syndrome type 2; Stickler syndrome type 3; Otospondylomegaepiphyseal dysplasia (OSMED); Marshall syndrome; Weissenbacher-Zweymuller syndrome Deafness, autosomal dominant Ossification of the posterior longitudinal ligament of spine (OPLL)
GWAS		Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Leukocyte telomere length ( 32109421) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 27863252 28957414 32888494)	Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Asthma ( 30929738) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Height ( 31217584) Hip circumference adjusted for BMI ( 34021172) Lung cancer ( 28604730) Rosacea symptom severity ( 29771307) Sjögren's syndrome ( 24097066) Thyrotoxic hypokalemic periodic paralysis and Graves disease ( 31050781) Wegener's granulomatosis ( 23740775)
Interacting Genes		166 interacting genes: A1BG A2M AAMP ABHD4 ACTB ACTL6B ACTR1B ADAMTS10 ADD1 AGAP1 ALAS1 ALB APLP1 APP ARFGAP1 ATG16L2 ATP5F1B ATP6V1A ATXN3 BAG6 BOLA2 BOLA2B CARHSP1 CCDC90B CDC20 CDK1 CDK4 CDKN1A CENPB CFTR CHGB CLEC3B COL11A2 COL4A2 COL4A5 COPS6 CPNE6 CRIP2 CRMP1 CSAD DACT1 DALRD3 DCAF13 DDAH2 DEAF1 DMPK DOCK7 DRAP1 DUS2 DYNC1I1 DYNC2I1 DYNLT2B EEF1A1 EIF3G EIF4A2 EIF6 ERG28 EXT2 EZH2 F13A1 FAF1 FAM20C FBN3 FGB FLAD1 FST FZR1 GAPDH GDF9 GDI1 GET3 GLB1 GPCPD1 HADHB HERC3 HMGXB3 HSPBAP1 IER3IP1 IGHM IMMT INPP5K INTS11 ITSN1 JADE1 JMJD1C KDM6B KIF21B KIF5A KLHL23 KLHL5 KMT2B LRIF1 MAGEA4 MAST2 MED31 METTL23 MKI67 MPP1 MPPED1 MRFAP1 MRPL20-AS1 MRPL37 MSH2 NEUROD2 NGFR NKIRAS2 NMT2 NRBP1 ODC1 PAAF1 PDE4DIP PJA1 PKM PLD3 PLXNA3 PPP4C PRMT1 PROC PSME1 PTPN4 PTPRK QARS1 RBBP4 RBM48 REX1BD RPA1 RPL13 RPS2 RUVBL1 RXRA SDF4 SEMA5B SEPTIN6 SETDB1 SEZ6L2 SMC5 SNX1 SP110 SULT1A3 SUMO2 SUMO3 TAF1C THOC3 TIAM2 TLE1 TMSB4X TP53 TRIM46 TRMT2A TSC2 TTC38 TUBA1A TUBB2A TUBB3 TYK2 UBC UNC119 UPF2 USP4 VMA22 WDR18 WDR73 WIZ ZBTB16 ZNF431 ZXDC	3 interacting genes: ANXA7 PIN1 TK1
Entrez ID		7083	1302
HPRD ID		01771	00376
Ensembl ID		ENSG00000167900	ENSG00000204248
Uniprot IDs		A0A384MDV9 K7ERV3 K7ES52 P04183	A0A0C4DFS1 A0A0G2JL35 A0A0G2JL78 A0A140TA43 P13942 Q4VXY6
PDB IDs		1W4R 1XBT 2ORV 2WVJ
Enriched GO Terms of Interacting Partners?		Cytoplasm Macromolecule Metabolic Process Protein Metabolic Process Platelet Alpha Granule Lumen Chromatin Organization Blood Microparticle Negative Regulation Of Cell Cycle G1/S Phase Transition Chromatin Remodeling Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Extracellular Exosome Cytosol Regulation Of DNA Replication Regulation Of G1/S Transition Of Mitotic Cell Cycle Protein Binding Nucleoplasm Positive Regulation Of Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Transferase Activity Nuclear Matrix Regulation Of Protein Catabolic Process DNA Synthesis Involved In Mitotic DNA Replication Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Macromolecule Biosynthetic Process Chromosome, Telomeric Region Positive Regulation Of Protein Metabolic Process Cytoskeleton Negative Regulation Of Cell Cycle Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Protein Tag Activity Developmental Process Growth Cone Protein Modification Process Cellular Response To Norepinephrine Stimulus Response To Norepinephrine Mitotic DNA Damage Checkpoint Signaling Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Oocyte Growth	Neuron Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Cellular Response To Diamide Protein Peptidyl-prolyl Isomerization Phosphothreonine Residue Binding Cis-trans Isomerase Activity DNA Synthesis Involved In Mitotic DNA Replication Thymidine Kinase Activity Response To Sodium Arsenite Cellular Response To Salt Cellular Response To Sodium Arsenite Protein-containing Complex Assembly Phosphoserine Residue Binding Thymidine Metabolic Process Thymidine Biosynthetic Process Chromaffin Granule Membrane Response To Metal Ion Protein-containing Complex Organization Deoxyribonucleoside Monophosphate Biosynthetic Process Mitogen-activated Protein Kinase Kinase Binding GTPase Activating Protein Binding Response To Phorbol 13-acetate 12-myristate Ubiquitin Ligase Activator Activity Pyrimidine Nucleoside Metabolic Process Cellular Response To Arsenic-containing Substance Cellular Response To Unfolded Protein Cellular Response To Cadmium Ion Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Androgen Receptor Signaling Pathway Microtubule Polymerization Cellular Response To Copper Ion Nuclear Androgen Receptor Binding Cellular Response To Topologically Incorrect Protein Response To Salt Response To Arsenic-containing Substance Negative Regulation Of Amyloid Precursor Protein Catabolic Process Protein Targeting To Mitochondrion Postsynaptic Cytosol Negative Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Amyloid-beta Formation
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