TK1 and F13A1

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		TK1	F13A1
Gene Name		thymidine kinase 1, soluble	coagulation factor XIII, A1 polypeptide
Image
Gene Ontology Annotations	Cellular Component	Cytosol	Extracellular Region Platelet Alpha Granule Lumen Blood Microparticle
	Molecular Function	Thymidine Kinase Activity ATP Binding Zinc Ion Binding Nucleoside Kinase Activity Identical Protein Binding	Protein-glutamine Gamma-glutamyltransferase Activity Metal Ion Binding
	Biological Process	Liver Development Nucleobase-containing Compound Metabolic Process Pyrimidine Nucleobase Metabolic Process Deoxyribonucleoside Monophosphate Biosynthetic Process Nucleotide Biosynthetic Process Response To Toxic Substance Skeletal Muscle Cell Proliferation Phosphorylation Response To Nutrient Levels Pyrimidine Nucleoside Salvage Small Molecule Metabolic Process Thymidine Metabolic Process Response To Copper Ion Digestive Tract Development Protein Homotetramerization Response To Cortisol Nucleobase-containing Small Molecule Metabolic Process Fetal Process Involved In Parturition DNA Biosynthetic Process	Platelet Degranulation Blood Coagulation Peptide Cross-linking Platelet Activation
Pathways		Pyrimidine salvage reactions Pyrimidine metabolism Metabolism of nucleotides	Common Pathway Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation Formation of Fibrin Clot (Clotting Cascade)
Drugs		Dithioerythritol Thymidine-5\'-Triphosphate	1,2-Propanediol N-Acetyl-Serine
Diseases
GWAS			End-stage coagulation ( 23381943) MRI atrophy measures ( 21116278)
Protein-Protein Interactions		159 interactors: A1BG A2M AAMP ABHD4 ACTB ACTL6B ACTR1B ADAMTS10 ADD1 AGAP1 ALAS1 ALB APLP1 APP ARFGAP1 ASNA1 ATG16L2 ATP5B ATP6V1A ATXN3 BAG6 C14orf1 C19orf60 CARHSP1 CCDC115 CCDC90B CDC20 CDK1 CDK4 CDKN1A CENPB CHGB CLEC3B COL11A2 COL4A2 COL4A5 COPS6 CPNE6 CPSF3L CRIP2 CRMP1 CSAD DACT1 DALRD3 DCAF13 DDAH2 DEAF1 DMPK DOCK7 DRAP1 DUS2 DYNC1I1 EEF1A1 EIF3G EIF4A2 EIF6 EXT2 EZH2 F13A1 FAF1 FAM20C FBN3 FGB FLAD1 FST FZR1 GAPDH GDF9 GDI1 GLB1 GPCPD1 HADHB HERC3 HMGXB3 HSPBAP1 IER3IP1 IGHM IMMT INPP5K ITSN1 JADE1 JMJD1C KDM6B KIF21B KIF5A KLHL23 KLHL5 KMT2B LOC148413 LRIF1 MAGEA4 MAST2 MED31 METTL23 MKI67 MPP1 MPPED1 MRFAP1 MRPL37 MSH2 NEUROD2 NGFR NKIRAS2 NMT2 NRBP1 ODC1 PAAF1 PDE4DIP PKM PLD3 PLXNA3 PPP4C PROC PSME1 PTPN4 PTPRK QARS RBBP4 RBM48 RPA1 RPL13 RPS2 RUVBL1 RXRA SDF4 SEMA5B SEPT6 SETDB1 SEZ6L2 SMC5 SNX1 SP110 SULT1A3 SUMO3 TAF1C TCTEX1D2 THOC3 TIAM2 TLE1 TMSB4X TP53 TRIM46 TRMT2A TSC2 TTC38 TUBA1A TUBB2A TUBB3 TYK2 UNC119 UPF2 USP4 WDR18 WDR60 WDR73 WIZ ZBTB16 ZNF431 ZXDC	13 interactors: ANXA7 CDKN1A F13B F2 FGA FGG FN1 NUDT21 PTK2 SERPINF2 SH3GL2 TK1 UFD1L
Entrez ID		7083	2162
HPRD ID		01771	00604
Ensembl ID		ENSG00000167900	ENSG00000124491
Uniprot IDs		P04183	P00488
PDB IDs		1W4R 1XBT 2ORV 2WVJ	1EVU 1EX0 1F13 1FIE 1GGT 1GGU 1GGY 1QRK
Enriched GO Terms of Interacting Partners?		Cellular Metabolic Process Regulation Of Protein Metabolic Process Cellular Protein Metabolic Process Developmental Process Anatomical Structure Development System Development Regulation Of Cellular Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Multicellular Organismal Development Cellular Localization Metabolic Process Regulation Of Metabolic Process Organelle Organization Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Protein Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Catabolic Process RNA Metabolic Process Negative Regulation Of Cell Cycle Posttranscriptional Regulation Of Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Cellular Metabolic Process Cell Differentiation Platelet Degranulation Gene Expression Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Negative Regulation Of Mitotic Cell Cycle Cellular Process Biosynthetic Process Regulation Of Cell Cycle Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Cell Cycle Process Mitotic Cell Cycle Process Axon Guidance Chromatin Organization Viral Process Programmed Cell Death Negative Regulation Of Mitotic Cell Cycle Phase Transition Chromosome Organization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Organic Substance Mitotic Cell Cycle Cellular Response To Growth Factor Stimulus	Hemostasis Regulation Of Body Fluid Levels Platelet Activation Blood Coagulation Wound Healing Response To Wounding Platelet Degranulation Regulation Of Cell Morphogenesis Regulation Of Cellular Component Organization Cell Activation Extracellular Matrix Organization Extracellular Structure Organization Acute-phase Response Regulation Of Cell Shape Positive Regulation Of Phosphorylation Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Protein Complex Assembly Acute Inflammatory Response Negative Regulation Of Fibrinolysis Response To Stress Positive Regulation Of Heterotypic Cell-cell Adhesion Regulation Of Blood Coagulation Regulation Of Fibrinolysis Response To Metal Ion Exocytosis Response To Calcium Ion Regulation Of Phosphorylation Regulation Of Cell-cell Adhesion Defense Response Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Wound Healing Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Development Vesicle-mediated Transport Regulation Of Phosphorus Metabolic Process Negative Regulation Of Endothelial Cell Apoptotic Process Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Morphogenesis Involved In Differentiation Positive Regulation Of Collagen Biosynthetic Process Regulation Of Cell Differentiation ERBB Signaling Pathway Positive Regulation Of Collagen Metabolic Process Response To Inorganic Substance Cell-matrix Adhesion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Fibrinolysis Secretion By Cell
Tagcloud ?		american artiodactyla assigned block blot cattle chr conservative conserved cow electrophoresis erbb2 hybrid hybridization localization localized means mink nf1 pepa pig prkca rara representatives sheep southern swine synteny umph2	10p13 17q21 5q15 6p24 australian british cl cleft crtl1 d1s58 d1s65 der excluded flank inheritance linkage lip lod multipoint palate rara syndromic theta unrelated van vim vws woude z
Tagcloud (Difference) ?		american artiodactyla assigned block blot cattle chr conservative conserved cow electrophoresis erbb2 hybrid hybridization localization localized means mink nf1 pepa pig prkca representatives sheep southern swine synteny umph2	10p13 17q21 5q15 6p24 australian british cl cleft crtl1 d1s58 d1s65 der excluded flank inheritance linkage lip lod multipoint palate syndromic theta unrelated van vim vws woude z
Tagcloud (Intersection) ?		rara