TK1 and NKIRAS2

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		TK1	NKIRAS2
Description		thymidine kinase 1	NFKB inhibitor interacting Ras like 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Cytoplasm
	Molecular Function	Nucleotide Binding Thymidine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Identical Protein Binding Metal Ion Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding GTPase Activating Protein Binding
	Biological Process	Nucleobase-containing Compound Metabolic Process Deoxyribonucleoside Monophosphate Biosynthetic Process Thymidine Metabolic Process Thymidine Biosynthetic Process Protein Homotetramerization DNA Biosynthetic Process DNA Synthesis Involved In Mitotic DNA Replication	Inflammatory Response Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Ral Protein Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Surfactant Homeostasis Lung Alveolus Development
Pathways		G1/S-Specific Transcription Pyrimidine salvage	RIP-mediated NFkB activation via ZBP1 TAK1-dependent IKK and NF-kappa-B activation TRAF6 mediated NF-kB activation
Drugs		Dithioerythritol Thymidine 5'-triphosphate
Diseases
GWAS		Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Leukocyte telomere length ( 32109421) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 27863252 28957414 32888494)
Interacting Genes		166 interacting genes: A1BG A2M AAMP ABHD4 ACTB ACTL6B ACTR1B ADAMTS10 ADD1 AGAP1 ALAS1 ALB APLP1 APP ARFGAP1 ATG16L2 ATP5F1B ATP6V1A ATXN3 BAG6 BOLA2 BOLA2B CARHSP1 CCDC90B CDC20 CDK1 CDK4 CDKN1A CENPB CFTR CHGB CLEC3B COL11A2 COL4A2 COL4A5 COPS6 CPNE6 CRIP2 CRMP1 CSAD DACT1 DALRD3 DCAF13 DDAH2 DEAF1 DMPK DOCK7 DRAP1 DUS2 DYNC1I1 DYNC2I1 DYNLT2B EEF1A1 EIF3G EIF4A2 EIF6 ERG28 EXT2 EZH2 F13A1 FAF1 FAM20C FBN3 FGB FLAD1 FST FZR1 GAPDH GDF9 GDI1 GET3 GLB1 GPCPD1 HADHB HERC3 HMGXB3 HSPBAP1 IER3IP1 IGHM IMMT INPP5K INTS11 ITSN1 JADE1 JMJD1C KDM6B KIF21B KIF5A KLHL23 KLHL5 KMT2B LRIF1 MAGEA4 MAST2 MED31 METTL23 MKI67 MPP1 MPPED1 MRFAP1 MRPL20-AS1 MRPL37 MSH2 NEUROD2 NGFR NKIRAS2 NMT2 NRBP1 ODC1 PAAF1 PDE4DIP PJA1 PKM PLD3 PLXNA3 PPP4C PRMT1 PROC PSME1 PTPN4 PTPRK QARS1 RBBP4 RBM48 REX1BD RPA1 RPL13 RPS2 RUVBL1 RXRA SDF4 SEMA5B SEPTIN6 SETDB1 SEZ6L2 SMC5 SNX1 SP110 SULT1A3 SUMO2 SUMO3 TAF1C THOC3 TIAM2 TLE1 TMSB4X TP53 TRIM46 TRMT2A TSC2 TTC38 TUBA1A TUBB2A TUBB3 TYK2 UBC UNC119 UPF2 USP4 VMA22 WDR18 WDR73 WIZ ZBTB16 ZNF431 ZXDC	5 interacting genes: NFKBIA NFKBIB PAX6 SMN1 TK1
Entrez ID		7083	28511
HPRD ID		01771	07261
Ensembl ID		ENSG00000167900	ENSG00000168256
Uniprot IDs		A0A384MDV9 K7ERV3 K7ES52 P04183	Q9NYR9
PDB IDs		1W4R 1XBT 2ORV 2WVJ
Enriched GO Terms of Interacting Partners?		Cytoplasm Macromolecule Metabolic Process Protein Metabolic Process Platelet Alpha Granule Lumen Chromatin Organization Blood Microparticle Negative Regulation Of Cell Cycle G1/S Phase Transition Chromatin Remodeling Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Extracellular Exosome Cytosol Regulation Of DNA Replication Regulation Of G1/S Transition Of Mitotic Cell Cycle Protein Binding Nucleoplasm Positive Regulation Of Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Transferase Activity Nuclear Matrix Regulation Of Protein Catabolic Process DNA Synthesis Involved In Mitotic DNA Replication Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Macromolecule Biosynthetic Process Chromosome, Telomeric Region Positive Regulation Of Protein Metabolic Process Cytoskeleton Negative Regulation Of Cell Cycle Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Protein Tag Activity Developmental Process Growth Cone Protein Modification Process Cellular Response To Norepinephrine Stimulus Response To Norepinephrine Mitotic DNA Damage Checkpoint Signaling Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Oocyte Growth	Nucleobase-containing Compound Biosynthetic Process Signal Transduction Involved In Regulation Of Gene Expression Macromolecule Biosynthetic Process Forebrain-midbrain Boundary Formation Pancreatic A Cell Development I-kappaB/NF-kappaB Complex Nucleic Acid Metabolic Process Habenula Development Pallium Development DNA Synthesis Involved In Mitotic DNA Replication Thymidine Kinase Activity Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Forebrain Dorsal/ventral Pattern Formation Regulation Of Asymmetric Cell Division Oligodendrocyte Cell Fate Specification Formation Of Anatomical Boundary Glial Cell Fate Specification Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Cerebral Cortex Regionalization Lacrimal Gland Development Telencephalon Regionalization Thymidine Metabolic Process Thymidine Biosynthetic Process Nucleobase-containing Compound Metabolic Process Forebrain Neuron Fate Commitment Ventral Spinal Cord Development Iris Morphogenesis Response To Molecule Of Bacterial Origin Response To Lipopolysaccharide Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Ubiquitin Protein Ligase Binding Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Macrophage Derived Foam Cell Differentiation Cytosol Type B Pancreatic Cell Differentiation HMG Box Domain Binding Co-SMAD Binding Regulation Of Timing Of Cell Differentiation Cornea Development In Camera-type Eye Salivary Gland Morphogenesis Negative Regulation Of Neuroblast Proliferation SMN Complex Gemini Of Cajal Bodies Pyrimidine Nucleoside Metabolic Process Deoxyribonucleoside Monophosphate Biosynthetic Process Cellular Response To Cold Dorsal/ventral Axis Specification Regulation Of Development, Heterochronic Embryonic Camera-type Eye Morphogenesis Enteroendocrine Cell Differentiation
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