TK1 and SNX1

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		TK1	SNX1
Gene Name		thymidine kinase 1, soluble	sorting nexin 1
Image
Gene Ontology Annotations	Cellular Component	Cytosol	Cytoplasm Golgi Apparatus Cytosol Endosome Membrane Membrane Extrinsic Component Of Membrane Lamellipodium Retromer Complex Early Endosome Membrane Intracellular Membrane-bounded Organelle Protein Complex
	Molecular Function	Thymidine Kinase Activity ATP Binding Zinc Ion Binding Nucleoside Kinase Activity Identical Protein Binding	Epidermal Growth Factor Receptor Binding Insulin Receptor Binding Protein Binding Phosphatidylinositol Binding Identical Protein Binding Transferrin Receptor Binding Leptin Receptor Binding
	Biological Process	Liver Development Nucleobase-containing Compound Metabolic Process Pyrimidine Nucleobase Metabolic Process Deoxyribonucleoside Monophosphate Biosynthetic Process Nucleotide Biosynthetic Process Response To Toxic Substance Skeletal Muscle Cell Proliferation Phosphorylation Response To Nutrient Levels Pyrimidine Nucleoside Salvage Small Molecule Metabolic Process Thymidine Metabolic Process Response To Copper Ion Digestive Tract Development Protein Homotetramerization Response To Cortisol Nucleobase-containing Small Molecule Metabolic Process Fetal Process Involved In Parturition DNA Biosynthetic Process	Intracellular Protein Transport Vesicle Organization Receptor Internalization Early Endosome To Golgi Transport Retrograde Transport, Endosome To Golgi Positive Regulation Of Protein Catabolic Process Lamellipodium Morphogenesis
Pathways		Pyrimidine salvage reactions Pyrimidine metabolism Metabolism of nucleotides
Drugs		Dithioerythritol Thymidine-5\'-Triphosphate
Diseases
GWAS
Protein-Protein Interactions		159 interactors: A1BG A2M AAMP ABHD4 ACTB ACTL6B ACTR1B ADAMTS10 ADD1 AGAP1 ALAS1 ALB APLP1 APP ARFGAP1 ASNA1 ATG16L2 ATP5B ATP6V1A ATXN3 BAG6 C14orf1 C19orf60 CARHSP1 CCDC115 CCDC90B CDC20 CDK1 CDK4 CDKN1A CENPB CHGB CLEC3B COL11A2 COL4A2 COL4A5 COPS6 CPNE6 CPSF3L CRIP2 CRMP1 CSAD DACT1 DALRD3 DCAF13 DDAH2 DEAF1 DMPK DOCK7 DRAP1 DUS2 DYNC1I1 EEF1A1 EIF3G EIF4A2 EIF6 EXT2 EZH2 F13A1 FAF1 FAM20C FBN3 FGB FLAD1 FST FZR1 GAPDH GDF9 GDI1 GLB1 GPCPD1 HADHB HERC3 HMGXB3 HSPBAP1 IER3IP1 IGHM IMMT INPP5K ITSN1 JADE1 JMJD1C KDM6B KIF21B KIF5A KLHL23 KLHL5 KMT2B LOC148413 LRIF1 MAGEA4 MAST2 MED31 METTL23 MKI67 MPP1 MPPED1 MRFAP1 MRPL37 MSH2 NEUROD2 NGFR NKIRAS2 NMT2 NRBP1 ODC1 PAAF1 PDE4DIP PKM PLD3 PLXNA3 PPP4C PROC PSME1 PTPN4 PTPRK QARS RBBP4 RBM48 RPA1 RPL13 RPS2 RUVBL1 RXRA SDF4 SEMA5B SEPT6 SETDB1 SEZ6L2 SMC5 SNX1 SP110 SULT1A3 SUMO3 TAF1C TCTEX1D2 THOC3 TIAM2 TLE1 TMSB4X TP53 TRIM46 TRMT2A TSC2 TTC38 TUBA1A TUBB2A TUBB3 TYK2 UNC119 UPF2 USP4 WDR18 WDR60 WDR73 WIZ ZBTB16 ZNF431 ZXDC	25 interactors: ACVR1B ACVR2B AGTRAP APP ARFIP2 ARL6IP1 ATXN7 CMTM5 EGFR F2R FUNDC1 HGS INSR LEPR PDGFRB RABAC1 REEP6 RTN3 RTN4 SNX2 SNX32 SNX6 TK1 UFD1L VPS35
Entrez ID		7083	6642
HPRD ID		01771	03171
Ensembl ID		ENSG00000167900	ENSG00000028528
Uniprot IDs		P04183	Q13596
PDB IDs		1W4R 1XBT 2ORV 2WVJ	2I4K 4FZS
Enriched GO Terms of Interacting Partners?		Cellular Metabolic Process Regulation Of Protein Metabolic Process Cellular Protein Metabolic Process Developmental Process Anatomical Structure Development System Development Regulation Of Cellular Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Multicellular Organismal Development Cellular Localization Metabolic Process Regulation Of Metabolic Process Organelle Organization Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Protein Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Catabolic Process RNA Metabolic Process Negative Regulation Of Cell Cycle Posttranscriptional Regulation Of Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Cellular Metabolic Process Cell Differentiation Platelet Degranulation Gene Expression Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Negative Regulation Of Mitotic Cell Cycle Cellular Process Biosynthetic Process Regulation Of Cell Cycle Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Cell Cycle Process Mitotic Cell Cycle Process Axon Guidance Chromatin Organization Viral Process Programmed Cell Death Negative Regulation Of Mitotic Cell Cycle Phase Transition Chromosome Organization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Organic Substance Mitotic Cell Cycle Cellular Response To Growth Factor Stimulus	Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Regulation Of Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Establishment Of Protein Localization Regulation Of Phosphorus Metabolic Process Regulation Of Kinase Activity Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Digestive System Development Negative Regulation Of ERBB Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Migration Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Positive Regulation Of Activin Receptor Signaling Pathway Endoplasmic Reticulum Tubular Network Organization Regulation Of Signal Transduction Regulation Of Cell Motility Retrograde Transport, Endosome To Golgi Protein Transport Regulation Of Locomotion Regulation Of Cellular Component Movement Endosomal Transport Regulation Of Peptidyl-tyrosine Phosphorylation Vesicle Organization Protein Localization Protein Autophosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Signaling Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Cell Surface Receptor Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Kinase Activity Regulation Of JAK-STAT Cascade Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Protein Metabolic Process Activation Of Protein Kinase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Signal Transduction By Phosphorylation Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Cycle Positive Regulation Of Transferase Activity Positive Regulation Of Protein Modification Process Intracellular Protein Transport Positive Regulation Of Mitotic Cell Cycle
Tagcloud ?		american artiodactyla assigned block blot cattle chr conservative conserved cow electrophoresis erbb2 hybrid hybridization localization localized means mink nf1 pepa pig prkca rara representatives sheep southern swine synteny umph2	apical auxin brassinosteroid bundle carrier clasp cytokinin cytoskeleton division edges efflux elongation endosomes fine maxima meristem microtubule microtubules modulates normally optimize pin2 prevailing sharp tethering transfacial transitions tunes works
Tagcloud (Difference) ?		american artiodactyla assigned block blot cattle chr conservative conserved cow electrophoresis erbb2 hybrid hybridization localization localized means mink nf1 pepa pig prkca rara representatives sheep southern swine synteny umph2	apical auxin brassinosteroid bundle carrier clasp cytokinin cytoskeleton division edges efflux elongation endosomes fine maxima meristem microtubule microtubules modulates normally optimize pin2 prevailing sharp tethering transfacial transitions tunes works
Tagcloud (Intersection) ?