ALAS1 and C2orf42

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		ALAS1	C2orf42
Gene Name		5-aminolevulinate synthase 1	chromosome 2 open reading frame 42
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix	Nucleus Nucleoplasm Nuclear Membrane
	Molecular Function	5-aminolevulinate Synthase Activity Pyridoxal Phosphate Binding
	Biological Process	Porphyrin-containing Compound Metabolic Process Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Organelle Organization Mitochondrion Organization Cellular Lipid Metabolic Process Small Molecule Metabolic Process
Pathways		PPARA activates gene expression Heme biosynthesis Organelle biogenesis and maintenance Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Metabolism of porphyrins Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis Mitochondrial biogenesis
Drugs		Pyridoxal Phosphate Glycine
Diseases
GWAS		Bipolar disorder ( 21926972)	Obesity-related traits ( 23251661)
Protein-Protein Interactions		40 interactors: BCL7A C2orf42 C8orf33 CCHCR1 CDC73 CDK5 CDKN1A CERK DUSP19 EP400 FAM127C GNL3L KLHL35 LONRF1 MTFR2 NUDT3 PIK3CB PLAU POLDIP2 PPL RAP1B SH2D4A SNX20 STAMBP SUMO2 TCEA2 TEKT4 TK1 TMSB10 TMSB4X TMSB4XP1 TMSB4XP2 TMSB4XP6 TTC23 USP20 WIPF1 ZFYVE26 ZMAT1 ZNF175 ZNF564	3 interactors: ALAS1 ECT2 PAXIP1
Entrez ID		211	54980
HPRD ID		00505	07927
Ensembl ID		ENSG00000023330	ENSG00000115998
Uniprot IDs		P13196 Q5JAM2	Q9NWW7
PDB IDs
Enriched GO Terms of Interacting Partners?		Sequestering Of Actin Monomers Blood Coagulation Hemostasis Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity	Response To Ionizing Radiation Positive Regulation Of Histone H3-K36 Methylation Chorion Development Response To Radiation Protoporphyrinogen IX Biosynthetic Process Protoporphyrinogen IX Metabolic Process Activation Of Rac GTPase Activity Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Histone H3-K4 Methylation Positive Regulation Of DNA-templated Transcription, Initiation Positive Regulation Of Cdc42 GTPase Activity Positive Regulation Of Histone Acetylation Regulation Of DNA-templated Transcription, Initiation Regulation Of Attachment Of Spindle Microtubules To Kinetochore Regulation Of Histone H3-K4 Methylation Positive Regulation Of Peptidyl-lysine Acetylation Positive Regulation Of Isotype Switching Positive Regulation Of Protein Acetylation Regulation Of Cdc42 GTPase Activity Heme Biosynthetic Process Regulation Of Cdc42 Protein Signal Transduction Histone H3-K4 Methylation Regulation Of Isotype Switching Positive Regulation Of Protein Modification Process Regulation Of Organelle Organization Positive Regulation Of Immunoglobulin Mediated Immune Response Porphyrin-containing Compound Biosynthetic Process Adipose Tissue Development Positive Regulation Of Histone Methylation Positive Regulation Of Immunoglobulin Production Activation Of Rho GTPase Activity Positive Regulation Of Cytokinesis Heme Metabolic Process Regulation Of Histone Acetylation Tight Junction Assembly Response To Abiotic Stimulus Cellular Response To Calcium Ion Positive Regulation Of Cellular Protein Metabolic Process Porphyrin-containing Compound Metabolic Process Regulation Of Histone Methylation Activation Of Ras GTPase Activity Positive Regulation Of Rac GTPase Activity Regulation Of Cytokinesis Cellular Response To Ionizing Radiation Cellular Response To Hydrogen Peroxide Pigment Biosynthetic Process Positive Regulation Of Protein Metabolic Process Regulation Of DNA Recombination Positive Regulation Of Histone Modification Apical Junction Assembly
Tagcloud ?		adequate arf1 candidate eif2b1 fbxw2 genorm gusb housekeeping hprt1 hysterectomy ideal leiomyoma menopausal menstrual mrpl19 myometrial myometrium normalization normfinder phases proliferative pum1 regardless secretory softwares standards taqman trim27 ube2d2
Tagcloud (Difference) ?		adequate arf1 candidate eif2b1 fbxw2 genorm gusb housekeeping hprt1 hysterectomy ideal leiomyoma menopausal menstrual mrpl19 myometrial myometrium normalization normfinder phases proliferative pum1 regardless secretory softwares standards taqman trim27 ube2d2
Tagcloud (Intersection) ?