ALAS1 and SNRPB2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ALAS1	SNRPB2
Description		5'-aminolevulinate synthase 1	small nuclear ribonucleoprotein polypeptide B2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Cytosol Membrane	Fibrillar Center Nucleus Nucleoplasm Spliceosomal Complex U2-type Spliceosomal Complex U1 SnRNP U2 SnRNP Nuclear Speck Cytoplasmic Ribonucleoprotein Granule U2-type Precatalytic Spliceosome U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome Spliceosomal SnRNP Complex Ribonucleoprotein Complex
	Molecular Function	5-aminolevulinate Synthase Activity Protein Binding Transferase Activity Acyltransferase Activity Pyridoxal Phosphate Binding Identical Protein Binding	Nucleic Acid Binding RNA Binding Protein Binding U1 SnRNA Binding
	Biological Process	Response To Hypoxia Porphyrin-containing Compound Metabolic Process Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Heme A Biosynthetic Process Heme B Biosynthetic Process Response To Xenobiotic Stimulus Response To Herbicide Response To Nickel Cation Response To Nutrient Levels Response To Cobalt Ion Cellular Response To Insulin Stimulus Tetrapyrrole Biosynthetic Process Response To Gonadotropin Hemoglobin Biosynthetic Process Response To Ethanol Heme O Biosynthetic Process Erythrocyte Development Response To CAMP Response To Platinum Ion Response To Bile Acid	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing U2-type Prespliceosome Assembly
Pathways		Heme biosynthesis PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Mitochondrial protein degradation	mRNA Splicing - Major Pathway
Drugs		Pyridoxal phosphate Pyridoxal phosphate Glycine
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Parkinson's disease ( 28892059) Schizophrenia ( 23974872)	Food allergy (maternal genetic effects) ( 29489655) Metabolite levels ( 23823483) Response to haloperidol in schizophrenia ( 29503163)
Interacting Genes		54 interacting genes: BCL7A C2orf42 C8orf33 CAP2 CCHCR1 CDC73 CDK5 CDKN1A CERK COBL EP400 FBXL8 FXR1 GNL3L GRXCR1 HSBP1L1 JRK KIF9 KLHL35 LONRF1 LRRC45 MTFR2 MTSS2 NUDT3 OXTR PIBF1 PIK3CB PLAU POLDIP2 PPL RAP1B RNF168 RTL8B SH2D4A SNRPB2 SNX20 STAMBP SUMO2 TCEA2 TEKT4 TK1 TMSB10 TMSB4X TMSB4XP1 TMSB4XP2 TMSB4XP6 TTC23 USP20 UTP14C WIPF1 ZFYVE26 ZMAT1 ZNF175 ZNF564	26 interacting genes: ALAS1 CALM1 CEBPA CMTM6 DHX9 ERBB3 FOXP1 GABPB1 GABPB2 GOLGA2 HMBOX1 HNRNPUL1 HOMEZ HTATSF1 MCM6 MTUS2 NAP1L5 PICK1 PNMA1 PTEN SMN2 SNRPA1 SUGP1 TRIM23 TRIM27 ZBTB14
Entrez ID		211	6629
HPRD ID		00505	04628
Ensembl ID		ENSG00000023330	ENSG00000125870
Uniprot IDs		B4DVA0 P13196 Q5JAM2	P08579
PDB IDs			1A9N 5MQF 5O9Z 5XJC 5YZG 5Z56 5Z57 5Z58 6AH0 6AHD 6FF7 6ICZ 6ID0 6ID1 6QDV 6QX9 6Y53 6Y5Q 7A5P 7ABG 7ABI 7EVO 7VPX 7W59 7W5A 7W5B 8C6J 8CH6 8H6E 8H6J 8H6K 8H6L 8HK1 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8I0W 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5 9FMD
Enriched GO Terms of Interacting Partners?		Actin Monomer Binding	Identical Protein Binding Nucleoplasm Nucleus RNA Splicing RNA Splicing, Via Transesterification Reactions Single-stranded 3'-5' DNA Helicase Activity RISC Complex Binding MRNA Metabolic Process CRD-mediated MRNA Stability Complex MRNA Processing Spliceosomal Complex Assembly Importin-alpha Family Protein Binding CRD-mediated MRNA Stabilization Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RNA Stem-loop Binding Cytoplasmic Ribonucleoprotein Granule Protein-RNA Complex Assembly MRNA Splicing, Via Spliceosome Meiotic Spindle Assembly Positive Regulation Of Cytoplasmic Translation DNA-templated Transcription Termination Regulation Of Viral Transcription Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Meiotic Spindle Organization Macromolecule Metabolic Process Transcription Cis-regulatory Region Binding Nucleic Acid Metabolic Process Alternative MRNA Splicing, Via Spliceosome PML Body U2-type Prespliceosome Assembly U2 SnRNP U2-type Spliceosomal Complex RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Dendritic Spine Organization Response To Stress Protein Binding Positive Regulation Of Biosynthetic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding 3'-5' DNA/RNA Helicase Activity Regulation Of Cytoplasmic Translation DNA-templated Viral Transcription Regulatory Region RNA Binding Negative Regulation Of Synaptic Vesicle Clustering Negative Regulation Of Organ Growth Regulation Of Actin Nucleation Telomere-telomerase Complex Assembly DNA Helicase Activity RNA Processing Nucleic Acid Binding
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