ALAS1 and STAMBP

Number of citations of the paper that reports this interaction (PubMedID 16730941)
0

Data Source:
HPRD (two hybrid)

		ALAS1	STAMBP
Description		5'-aminolevulinate synthase 1	STAM binding protein
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Cytosol Membrane	Nucleus Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Membrane Cleavage Furrow Extracellular Exosome
	Molecular Function	5-aminolevulinate Synthase Activity Protein Binding Transferase Activity Acyltransferase Activity Pyridoxal Phosphate Binding Identical Protein Binding	Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity Protein Domain Specific Binding Metal Ion Binding K63-linked Deubiquitinase Activity Deubiquitinase Activity Metal-dependent Deubiquitinase Activity
	Biological Process	Response To Hypoxia Porphyrin-containing Compound Metabolic Process Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Heme A Biosynthetic Process Heme B Biosynthetic Process Response To Xenobiotic Stimulus Response To Herbicide Response To Nickel Cation Response To Nutrient Levels Response To Cobalt Ion Cellular Response To Insulin Stimulus Tetrapyrrole Biosynthetic Process Response To Gonadotropin Hemoglobin Biosynthetic Process Response To Ethanol Heme O Biosynthetic Process Erythrocyte Development Response To CAMP Response To Platinum Ion Response To Bile Acid	Mitotic Cytokinesis Proteolysis Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Population Proliferation Protein Deubiquitination Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein K63-linked Deubiquitination Hippocampal Neuron Apoptotic Process Negative Regulation Of Hippocampal Neuron Apoptotic Process
Pathways		Heme biosynthesis PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Mitochondrial protein degradation	Metalloprotease DUBs
Drugs		Pyridoxal phosphate Pyridoxal phosphate Glycine
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Parkinson's disease ( 28892059) Schizophrenia ( 23974872)	Anti-saccade response ( 29064472) Bell's palsy ( 33602968) Blood metabolite levels ( 26401656) Serum metabolite levels ( 23093944 33031748)
Interacting Genes		54 interacting genes: BCL7A C2orf42 C8orf33 CAP2 CCHCR1 CDC73 CDK5 CDKN1A CERK COBL EP400 FBXL8 FXR1 GNL3L GRXCR1 HSBP1L1 JRK KIF9 KLHL35 LONRF1 LRRC45 MTFR2 MTSS2 NUDT3 OXTR PIBF1 PIK3CB PLAU POLDIP2 PPL RAP1B RNF168 RTL8B SH2D4A SNRPB2 SNX20 STAMBP SUMO2 TCEA2 TEKT4 TK1 TMSB10 TMSB4X TMSB4XP1 TMSB4XP2 TMSB4XP6 TTC23 USP20 UTP14C WIPF1 ZFYVE26 ZMAT1 ZNF175 ZNF564	51 interacting genes: ALAS1 AMN APOBEC3A ATG14 BMPR1B CASR CHMP1A CHMP1B CHMP2A CHMP3 CHMP4A CHMP4B CHMP4C CHMP5 CLTC CTNNBL1 CYP2C9 DSCR9 EGFR EPS15 GRAP2 GRB2 IL1RL2 ITGA5 MAP2K5 MAP3K2 MLKL NLRP7 NTPCR PJA1 RBM11 RECQL5 RNF11 SMAD2 SMAD6 SMAD7 SNCA SPG7 STAM STAM2 TNFRSF1A TP53 TRAF6 TRIP13 UACA UBC UBE2S ULK1 USP21 USP28 VHL
Entrez ID		211	10617
HPRD ID		00505	05877
Ensembl ID		ENSG00000023330	ENSG00000124356
Uniprot IDs		B4DVA0 P13196 Q5JAM2	A0A140VK54 A0A804HIF8 A0A804HII8 A0A804HJ64 O95630
PDB IDs			2XZE 3RZU 3RZV 5IXF
Enriched GO Terms of Interacting Partners?		Actin Monomer Binding	ESCRT III Complex Amphisome Membrane Vesicle Fusion With Vacuole Multivesicular Body Organization Multivesicular Body Assembly Multivesicular Body-lysosome Fusion Viral Budding From Plasma Membrane Late Endosome To Vacuole Transport Lysosomal Membrane Organization Endosome Transport Via Multivesicular Body Sorting Pathway Membrane Fission Multivesicular Body Sorting Pathway Late Endosome To Lysosome Transport Kinetochore Microtubule Autophagosome Membrane Viral Budding Via Host ESCRT Complex Regulation Of Mitotic Spindle Assembly Midbody Abscission Regulation Of Mitotic Spindle Organization Viral Budding Nuclear Membrane Reassembly Mitotic Cytokinetic Process Multivesicular Body Membrane Viral Release From Host Cell Plasma Membrane Repair Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Autophagosome Maturation Endosome Organization Regulation Of Spindle Assembly Autophagy Cytokinetic Process Protein-containing Complex Disassembly Endosomal Transport Multivesicular Body Mitotic Metaphase Chromosome Alignment Biological Process Involved In Interaction With Host Nuclear Membrane Organization Vacuolar Transport Vacuole Organization Metaphase Chromosome Alignment Membrane Assembly Endosome Macroautophagy Regulation Of Microtubule Cytoskeleton Organization Chromosome Localization Lysosomal Transport Regulation Of Centrosome Duplication Nuclear Pore Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Nucleus Organization
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