TK1 and COL4A2

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		TK1	COL4A2
Gene Name		thymidine kinase 1, soluble	collagen, type IV, alpha 2
Image
Gene Ontology Annotations	Cellular Component	Cytosol	Extracellular Region Collagen Type IV Trimer Endoplasmic Reticulum Lumen Extracellular Matrix Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome
	Molecular Function	Thymidine Kinase Activity ATP Binding Zinc Ion Binding Nucleoside Kinase Activity Identical Protein Binding	Extracellular Matrix Structural Constituent Protein Binding
	Biological Process	Liver Development Nucleobase-containing Compound Metabolic Process Pyrimidine Nucleobase Metabolic Process Deoxyribonucleoside Monophosphate Biosynthetic Process Nucleotide Biosynthetic Process Response To Toxic Substance Skeletal Muscle Cell Proliferation Phosphorylation Response To Nutrient Levels Pyrimidine Nucleoside Salvage Small Molecule Metabolic Process Thymidine Metabolic Process Response To Copper Ion Digestive Tract Development Protein Homotetramerization Response To Cortisol Nucleobase-containing Small Molecule Metabolic Process Fetal Process Involved In Parturition DNA Biosynthetic Process	Angiogenesis Transcription, DNA-templated Receptor-mediated Endocytosis Axon Guidance Negative Regulation Of Angiogenesis Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Endodermal Cell Differentiation Cellular Response To Transforming Growth Factor Beta Stimulus
Pathways		Pyrimidine salvage reactions Pyrimidine metabolism Metabolism of nucleotides	Signaling by PDGF NCAM1 interactions Collagen formation Axon guidance Collagen degradation Anchoring fibril formation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Laminin interactions ECM proteoglycans Integrin cell surface interactions Collagen biosynthesis and modifying enzymes NCAM signaling for neurite out-growth Scavenging by Class A Receptors
Drugs		Dithioerythritol Thymidine-5\'-Triphosphate
Diseases
GWAS			Coronary artery calcification ( 22144573) Coronary heart disease ( 21378990)
Protein-Protein Interactions		159 interactors: A1BG A2M AAMP ABHD4 ACTB ACTL6B ACTR1B ADAMTS10 ADD1 AGAP1 ALAS1 ALB APLP1 APP ARFGAP1 ASNA1 ATG16L2 ATP5B ATP6V1A ATXN3 BAG6 C14orf1 C19orf60 CARHSP1 CCDC115 CCDC90B CDC20 CDK1 CDK4 CDKN1A CENPB CHGB CLEC3B COL11A2 COL4A2 COL4A5 COPS6 CPNE6 CPSF3L CRIP2 CRMP1 CSAD DACT1 DALRD3 DCAF13 DDAH2 DEAF1 DMPK DOCK7 DRAP1 DUS2 DYNC1I1 EEF1A1 EIF3G EIF4A2 EIF6 EXT2 EZH2 F13A1 FAF1 FAM20C FBN3 FGB FLAD1 FST FZR1 GAPDH GDF9 GDI1 GLB1 GPCPD1 HADHB HERC3 HMGXB3 HSPBAP1 IER3IP1 IGHM IMMT INPP5K ITSN1 JADE1 JMJD1C KDM6B KIF21B KIF5A KLHL23 KLHL5 KMT2B LOC148413 LRIF1 MAGEA4 MAST2 MED31 METTL23 MKI67 MPP1 MPPED1 MRFAP1 MRPL37 MSH2 NEUROD2 NGFR NKIRAS2 NMT2 NRBP1 ODC1 PAAF1 PDE4DIP PKM PLD3 PLXNA3 PPP4C PROC PSME1 PTPN4 PTPRK QARS RBBP4 RBM48 RPA1 RPL13 RPS2 RUVBL1 RXRA SDF4 SEMA5B SEPT6 SETDB1 SEZ6L2 SMC5 SNX1 SP110 SULT1A3 SUMO3 TAF1C TCTEX1D2 THOC3 TIAM2 TLE1 TMSB4X TP53 TRIM46 TRMT2A TSC2 TTC38 TUBA1A TUBB2A TUBB3 TYK2 UNC119 UPF2 USP4 WDR18 WDR60 WDR73 WIZ ZBTB16 ZNF431 ZXDC	23 interactors: ANTXR2 ANXA7 APP ATF7IP BGN BMP3 CD93 COL4A1 CSNK2B DAZAP2 FAM46A FBLN2 FN1 HABP2 MATN2 MMP9 OSM SAA1 SERPINE2 SKIL SMN1 TGFBI TK1
Entrez ID		7083	1284
HPRD ID		01771	00355
Ensembl ID		ENSG00000167900	ENSG00000134871
Uniprot IDs		P04183	P08572
PDB IDs		1W4R 1XBT 2ORV 2WVJ	1LI1
Enriched GO Terms of Interacting Partners?		Cellular Metabolic Process Regulation Of Protein Metabolic Process Cellular Protein Metabolic Process Developmental Process Anatomical Structure Development System Development Regulation Of Cellular Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Multicellular Organismal Development Cellular Localization Metabolic Process Regulation Of Metabolic Process Organelle Organization Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Protein Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Catabolic Process RNA Metabolic Process Negative Regulation Of Cell Cycle Posttranscriptional Regulation Of Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Cellular Metabolic Process Cell Differentiation Platelet Degranulation Gene Expression Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Negative Regulation Of Mitotic Cell Cycle Cellular Process Biosynthetic Process Regulation Of Cell Cycle Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Cell Cycle Process Mitotic Cell Cycle Process Axon Guidance Chromatin Organization Viral Process Programmed Cell Death Negative Regulation Of Mitotic Cell Cycle Phase Transition Chromosome Organization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Organic Substance Mitotic Cell Cycle Cellular Response To Growth Factor Stimulus	Extracellular Matrix Organization Extracellular Structure Organization Tissue Development Chemotaxis Anatomical Structure Development System Development Nervous System Development Axon Guidance Cell Morphogenesis Involved In Differentiation Hemostasis Generation Of Neurons Developmental Process Multicellular Organismal Development Neurogenesis Cell Differentiation Locomotion Extracellular Matrix Disassembly Axonogenesis Response To External Stimulus Axon Development Regulation Of Body Fluid Levels Anatomical Structure Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Morphogenesis Movement Of Cell Or Subcellular Component Cell Morphogenesis Response To Wounding Blood Coagulation Endodermal Cell Differentiation Acute-phase Response Platelet Activation Neuron Projection Development Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Cell Projection Morphogenesis Cell Development Peptide Cross-linking Reproductive Process Cell Part Morphogenesis Seminal Vesicle Epithelium Development Fetal Process Involved In Parturition Dendrite Regeneration Mating Neuromuscular Junction Development Leukocyte Migration Regulation Of Pathway-restricted SMAD Protein Phosphorylation Endoderm Formation Neuron Development Collagen Catabolic Process Regulation Of Binding Behavior
Tagcloud ?		american artiodactyla assigned block blot cattle chr conservative conserved cow electrophoresis erbb2 hybrid hybridization localization localized means mink nf1 pepa pig prkca rara representatives sheep southern swine synteny umph2	13q33 bptf d13s1315 d13s158 d13s278 d13s285 d13s779 d13s796 e2f ets flanking genomatix heterozygosity hif1 ing ing1 loh matinspector microdeletion nrsf rel softwares sox sox1 tfsearch tsg tsgs warrants
Tagcloud (Difference) ?		american artiodactyla assigned block blot cattle chr conservative conserved cow electrophoresis erbb2 hybrid hybridization localization localized means mink nf1 pepa pig prkca rara representatives sheep southern swine synteny umph2	13q33 bptf d13s1315 d13s158 d13s278 d13s285 d13s779 d13s796 e2f ets flanking genomatix heterozygosity hif1 ing ing1 loh matinspector microdeletion nrsf rel softwares sox sox1 tfsearch tsg tsgs warrants
Tagcloud (Intersection) ?