ALAS1 and MTSS2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ALAS1	MTSS2
Description		5'-aminolevulinate synthase 1	MTSS I-BAR domain containing 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Cytosol Membrane	Ruffle Cytoplasm Plasma Membrane Cytoplasmic Side Of Plasma Membrane Actin Cytoskeleton Lamellipodium Cortical Actin Cytoskeleton Ruffle Membrane Cell Projection
	Molecular Function	5-aminolevulinate Synthase Activity Protein Binding Transferase Activity Acyltransferase Activity Pyridoxal Phosphate Binding Identical Protein Binding	Actin Binding Actin Monomer Binding GTPase Activator Activity Protein Binding Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Small GTPase Binding
	Biological Process	Response To Hypoxia Porphyrin-containing Compound Metabolic Process Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Heme A Biosynthetic Process Heme B Biosynthetic Process Response To Xenobiotic Stimulus Response To Herbicide Response To Nickel Cation Response To Nutrient Levels Response To Cobalt Ion Cellular Response To Insulin Stimulus Tetrapyrrole Biosynthetic Process Response To Gonadotropin Hemoglobin Biosynthetic Process Response To Ethanol Heme O Biosynthetic Process Erythrocyte Development Response To CAMP Response To Platinum Ion Response To Bile Acid	Plasma Membrane Organization Cell Projection Assembly Cellular Response To Platelet-derived Growth Factor Stimulus Membrane Organization Activation Of GTPase Activity Lamellipodium Organization
Pathways		Heme biosynthesis PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Mitochondrial protein degradation
Drugs		Pyridoxal phosphate Pyridoxal phosphate Glycine
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Parkinson's disease ( 28892059) Schizophrenia ( 23974872)
Interacting Genes		54 interacting genes: BCL7A C2orf42 C8orf33 CAP2 CCHCR1 CDC73 CDK5 CDKN1A CERK COBL EP400 FBXL8 FXR1 GNL3L GRXCR1 HSBP1L1 JRK KIF9 KLHL35 LONRF1 LRRC45 MTFR2 MTSS2 NUDT3 OXTR PIBF1 PIK3CB PLAU POLDIP2 PPL RAP1B RNF168 RTL8B SH2D4A SNRPB2 SNX20 STAMBP SUMO2 TCEA2 TEKT4 TK1 TMSB10 TMSB4X TMSB4XP1 TMSB4XP2 TMSB4XP6 TTC23 USP20 UTP14C WIPF1 ZFYVE26 ZMAT1 ZNF175 ZNF564	2 interacting genes: ALAS1 SCAF1
Entrez ID		211	92154
HPRD ID		00505	14289
Ensembl ID		ENSG00000023330	ENSG00000132613
Uniprot IDs		B4DVA0 P13196 Q5JAM2	Q765P7
PDB IDs
Enriched GO Terms of Interacting Partners?		Actin Monomer Binding	Heme O Biosynthetic Process Hemoglobin Metabolic Process Response To Herbicide Response To Cobalt Ion 5-aminolevulinate Synthase Activity Response To Nickel Cation Response To Bile Acid Response To Platinum Ion Heme A Biosynthetic Process Protoporphyrinogen IX Biosynthetic Process Protoporphyrinogen IX Metabolic Process Hemoglobin Biosynthetic Process Heme B Biosynthetic Process RNA Polymerase II C-terminal Domain Binding Heme Biosynthetic Process Tetrapyrrole Biosynthetic Process Porphyrin-containing Compound Biosynthetic Process Response To Gonadotropin Erythrocyte Development Heme Metabolic Process Porphyrin-containing Compound Metabolic Process Pyridoxal Phosphate Binding Tetrapyrrole Metabolic Process Pigment Metabolic Process Macromolecule Biosynthetic Process Myeloid Cell Development Response To CAMP Cellular Response To Insulin Stimulus Response To Toxic Substance Response To Ethanol Response To Purine-containing Compound Acyltransferase Activity
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