TK1 and MKI67

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		TK1	MKI67
Gene Name		thymidine kinase 1, soluble	marker of proliferation Ki-67
Image
Gene Ontology Annotations	Cellular Component	Cytosol	Chromosome, Centromeric Region Condensed Chromosome Nucleus Nucleolus Cytoplasm Membrane
	Molecular Function	Thymidine Kinase Activity ATP Binding Zinc Ion Binding Nucleoside Kinase Activity Identical Protein Binding	Protein Binding ATP Binding Protein C-terminus Binding Poly(A) RNA Binding
	Biological Process	Liver Development Nucleobase-containing Compound Metabolic Process Pyrimidine Nucleobase Metabolic Process Deoxyribonucleoside Monophosphate Biosynthetic Process Nucleotide Biosynthetic Process Response To Toxic Substance Skeletal Muscle Cell Proliferation Phosphorylation Response To Nutrient Levels Pyrimidine Nucleoside Salvage Small Molecule Metabolic Process Thymidine Metabolic Process Response To Copper Ion Digestive Tract Development Protein Homotetramerization Response To Cortisol Nucleobase-containing Small Molecule Metabolic Process Fetal Process Involved In Parturition DNA Biosynthetic Process	Meiotic Nuclear Division Cell Proliferation
Pathways		Pyrimidine salvage reactions Pyrimidine metabolism Metabolism of nucleotides
Drugs		Dithioerythritol Thymidine-5\'-Triphosphate
Diseases
GWAS			Select biomarker traits ( 17903293)
Protein-Protein Interactions		159 interactors: A1BG A2M AAMP ABHD4 ACTB ACTL6B ACTR1B ADAMTS10 ADD1 AGAP1 ALAS1 ALB APLP1 APP ARFGAP1 ASNA1 ATG16L2 ATP5B ATP6V1A ATXN3 BAG6 C14orf1 C19orf60 CARHSP1 CCDC115 CCDC90B CDC20 CDK1 CDK4 CDKN1A CENPB CHGB CLEC3B COL11A2 COL4A2 COL4A5 COPS6 CPNE6 CPSF3L CRIP2 CRMP1 CSAD DACT1 DALRD3 DCAF13 DDAH2 DEAF1 DMPK DOCK7 DRAP1 DUS2 DYNC1I1 EEF1A1 EIF3G EIF4A2 EIF6 EXT2 EZH2 F13A1 FAF1 FAM20C FBN3 FGB FLAD1 FST FZR1 GAPDH GDF9 GDI1 GLB1 GPCPD1 HADHB HERC3 HMGXB3 HSPBAP1 IER3IP1 IGHM IMMT INPP5K ITSN1 JADE1 JMJD1C KDM6B KIF21B KIF5A KLHL23 KLHL5 KMT2B LOC148413 LRIF1 MAGEA4 MAST2 MED31 METTL23 MKI67 MPP1 MPPED1 MRFAP1 MRPL37 MSH2 NEUROD2 NGFR NKIRAS2 NMT2 NRBP1 ODC1 PAAF1 PDE4DIP PKM PLD3 PLXNA3 PPP4C PROC PSME1 PTPN4 PTPRK QARS RBBP4 RBM48 RPA1 RPL13 RPS2 RUVBL1 RXRA SDF4 SEMA5B SEPT6 SETDB1 SEZ6L2 SMC5 SNX1 SP110 SULT1A3 SUMO3 TAF1C TCTEX1D2 THOC3 TIAM2 TLE1 TMSB4X TP53 TRIM46 TRMT2A TSC2 TTC38 TUBA1A TUBB2A TUBB3 TYK2 UNC119 UPF2 USP4 WDR18 WDR60 WDR73 WIZ ZBTB16 ZNF431 ZXDC	10 interactors: CBX3 CBX5 CDK1 HINFP KIAA0368 KIF15 NIFK PRKCB SMN1 TK1
Entrez ID		7083	4288
HPRD ID		01771	08902
Ensembl ID		ENSG00000167900	ENSG00000148773
Uniprot IDs		P04183	P46013
PDB IDs		1W4R 1XBT 2ORV 2WVJ	1R21 2AFF
Enriched GO Terms of Interacting Partners?		Cellular Metabolic Process Regulation Of Protein Metabolic Process Cellular Protein Metabolic Process Developmental Process Anatomical Structure Development System Development Regulation Of Cellular Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Multicellular Organismal Development Cellular Localization Metabolic Process Regulation Of Metabolic Process Organelle Organization Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Protein Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Catabolic Process RNA Metabolic Process Negative Regulation Of Cell Cycle Posttranscriptional Regulation Of Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Cellular Metabolic Process Cell Differentiation Platelet Degranulation Gene Expression Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Negative Regulation Of Mitotic Cell Cycle Cellular Process Biosynthetic Process Regulation Of Cell Cycle Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Cell Cycle Process Mitotic Cell Cycle Process Axon Guidance Chromatin Organization Viral Process Programmed Cell Death Negative Regulation Of Mitotic Cell Cycle Phase Transition Chromosome Organization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Organic Substance Mitotic Cell Cycle Cellular Response To Growth Factor Stimulus	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Response To Copper Ion Mitotic Nuclear Envelope Disassembly Mitotic Cell Cycle Process Histone Phosphorylation Response To Wounding Nuclear Envelope Disassembly Peptidyl-threonine Phosphorylation Mitotic Cell Cycle Nuclear Envelope Organization Pronuclear Fusion Fetal Process Involved In Parturition Blood Coagulation Cell Cycle Process Hemostasis Nucleobase-containing Compound Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Skeletal Muscle Cell Proliferation Histone H3-T6 Phosphorylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nucleus Organization Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Body Fluid Levels Macromolecule Biosynthetic Process Cell Cycle Wound Healing Chromatin Modification DNA Damage Checkpoint G1/S Transition Of Mitotic Cell Cycle Nitrogen Compound Metabolic Process Response To Toxic Substance Response To Cortisol Thymidine Metabolic Process Chromatin Organization Regulation Of Schwann Cell Differentiation Deoxyribonucleoside Monophosphate Biosynthetic Process Positive Regulation Of B Cell Receptor Signaling Pathway Pyrimidine Nucleoside Salvage Pyrimidine-containing Compound Salvage Protein Localization To Kinetochore Cell Cycle Checkpoint Protein Localization To Chromosome, Centromeric Region Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Import Into Nucleus, Translocation Proteasomal Protein Catabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cellular Component Assembly
Tagcloud ?		american artiodactyla assigned block blot cattle chr conservative conserved cow electrophoresis erbb2 hybrid hybridization localization localized means mink nf1 pepa pig prkca rara representatives sheep southern swine synteny umph2	analyze associations bax bcl2 birc5 bladder carcinogenesis ccnd1 ccne1 demonstrates egfr heterozygosity indices intron loh methylation methylscreen papillary polymerase positively reveal reverse suppressor technology transduction tumorigenesis urothelial vegf wwox
Tagcloud (Difference) ?		american artiodactyla assigned block blot cattle chr conservative conserved cow electrophoresis erbb2 hybrid hybridization localization localized means mink nf1 pepa pig prkca rara representatives sheep southern swine synteny umph2	analyze associations bax bcl2 birc5 bladder carcinogenesis ccnd1 ccne1 demonstrates egfr heterozygosity indices intron loh methylation methylscreen papillary polymerase positively reveal reverse suppressor technology transduction tumorigenesis urothelial vegf wwox
Tagcloud (Intersection) ?