TK1 and PLXNA3

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		TK1	PLXNA3
Gene Name		thymidine kinase 1, soluble	plexin A3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Semaphorin Receptor Complex Intracellular Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	Thymidine Kinase Activity ATP Binding Zinc Ion Binding Nucleoside Kinase Activity Identical Protein Binding	Transmembrane Signaling Receptor Activity Protein Binding Semaphorin Receptor Activity
	Biological Process	Liver Development Nucleobase-containing Compound Metabolic Process Pyrimidine Nucleobase Metabolic Process Deoxyribonucleoside Monophosphate Biosynthetic Process Nucleotide Biosynthetic Process Response To Toxic Substance Skeletal Muscle Cell Proliferation Phosphorylation Response To Nutrient Levels Pyrimidine Nucleoside Salvage Small Molecule Metabolic Process Thymidine Metabolic Process Response To Copper Ion Digestive Tract Development Protein Homotetramerization Response To Cortisol Nucleobase-containing Small Molecule Metabolic Process Fetal Process Involved In Parturition DNA Biosynthetic Process	Multicellular Organismal Development Axon Guidance Facial Nerve Structural Organization Trigeminal Nerve Structural Organization Hippocampus Development Branchiomotor Neuron Axon Guidance Pyramidal Neuron Development Negative Regulation Of Axon Extension Involved In Axon Guidance Negative Chemotaxis Positive Regulation Of Cytoskeleton Organization Semaphorin-plexin Signaling Pathway Semaphorin-plexin Signaling Pathway Involved In Axon Guidance
Pathways		Pyrimidine salvage reactions Pyrimidine metabolism Metabolism of nucleotides	Axon guidance Semaphorin interactions Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling
Drugs		Dithioerythritol Thymidine-5\'-Triphosphate
Diseases
GWAS
Protein-Protein Interactions		159 interactors: A1BG A2M AAMP ABHD4 ACTB ACTL6B ACTR1B ADAMTS10 ADD1 AGAP1 ALAS1 ALB APLP1 APP ARFGAP1 ASNA1 ATG16L2 ATP5B ATP6V1A ATXN3 BAG6 C14orf1 C19orf60 CARHSP1 CCDC115 CCDC90B CDC20 CDK1 CDK4 CDKN1A CENPB CHGB CLEC3B COL11A2 COL4A2 COL4A5 COPS6 CPNE6 CPSF3L CRIP2 CRMP1 CSAD DACT1 DALRD3 DCAF13 DDAH2 DEAF1 DMPK DOCK7 DRAP1 DUS2 DYNC1I1 EEF1A1 EIF3G EIF4A2 EIF6 EXT2 EZH2 F13A1 FAF1 FAM20C FBN3 FGB FLAD1 FST FZR1 GAPDH GDF9 GDI1 GLB1 GPCPD1 HADHB HERC3 HMGXB3 HSPBAP1 IER3IP1 IGHM IMMT INPP5K ITSN1 JADE1 JMJD1C KDM6B KIF21B KIF5A KLHL23 KLHL5 KMT2B LOC148413 LRIF1 MAGEA4 MAST2 MED31 METTL23 MKI67 MPP1 MPPED1 MRFAP1 MRPL37 MSH2 NEUROD2 NGFR NKIRAS2 NMT2 NRBP1 ODC1 PAAF1 PDE4DIP PKM PLD3 PLXNA3 PPP4C PROC PSME1 PTPN4 PTPRK QARS RBBP4 RBM48 RPA1 RPL13 RPS2 RUVBL1 RXRA SDF4 SEMA5B SEPT6 SETDB1 SEZ6L2 SMC5 SNX1 SP110 SULT1A3 SUMO3 TAF1C TCTEX1D2 THOC3 TIAM2 TLE1 TMSB4X TP53 TRIM46 TRMT2A TSC2 TTC38 TUBA1A TUBB2A TUBB3 TYK2 UNC119 UPF2 USP4 WDR18 WDR60 WDR73 WIZ ZBTB16 ZNF431 ZXDC	5 interactors: CSNK2B MAPK8IP2 PPP2CB SMN1 TK1
Entrez ID		7083	55558
HPRD ID		01771	02062
Ensembl ID		ENSG00000167900	ENSG00000130827
Uniprot IDs		P04183	P51805
PDB IDs		1W4R 1XBT 2ORV 2WVJ
Enriched GO Terms of Interacting Partners?		Cellular Metabolic Process Regulation Of Protein Metabolic Process Cellular Protein Metabolic Process Developmental Process Anatomical Structure Development System Development Regulation Of Cellular Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Multicellular Organismal Development Cellular Localization Metabolic Process Regulation Of Metabolic Process Organelle Organization Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Protein Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Catabolic Process RNA Metabolic Process Negative Regulation Of Cell Cycle Posttranscriptional Regulation Of Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Cellular Metabolic Process Cell Differentiation Platelet Degranulation Gene Expression Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Negative Regulation Of Mitotic Cell Cycle Cellular Process Biosynthetic Process Regulation Of Cell Cycle Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Cell Cycle Process Mitotic Cell Cycle Process Axon Guidance Chromatin Organization Viral Process Programmed Cell Death Negative Regulation Of Mitotic Cell Cycle Phase Transition Chromosome Organization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Organic Substance Mitotic Cell Cycle Cellular Response To Growth Factor Stimulus	Cellular Macromolecular Complex Assembly Cellular Component Assembly Fetal Process Involved In Parturition Skeletal Muscle Cell Proliferation Response To Toxic Substance Protein Complex Assembly Nonassociative Learning Phosphate-containing Compound Metabolic Process Response To Cortisol Thymidine Metabolic Process Positive Regulation Of Activin Receptor Signaling Pathway Deoxyribonucleoside Monophosphate Biosynthetic Process Adiponectin-activated Signaling Pathway Pyrimidine Nucleoside Salvage Pyrimidine-containing Compound Salvage Cellular Protein Complex Assembly Endothelial Tube Morphogenesis Signal Complex Assembly Response To Inorganic Substance Parturition Negative Regulation Of Blood Vessel Endothelial Cell Migration System Development Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Phosphorylation Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Regulation Of Activin Receptor Signaling Pathway Response To Copper Ion Cell Morphogenesis Involved In Neuron Differentiation Multicellular Organismal Development Neuron Projection Morphogenesis Mating Behavior Negative Regulation Of Endothelial Cell Migration Anatomical Structure Development Nervous System Development Behavioral Fear Response Pyrimidine Nucleobase Metabolic Process Tube Development Fear Response Cell Morphogenesis Involved In Differentiation Social Behavior Positive Regulation Of Protein Phosphorylation Spliceosomal SnRNP Assembly Regulation Of Protein Kinase Activity Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Epithelial Cell Migration Response To Organic Substance Regulation Of Kinase Activity Pyrimidine Nucleoside Biosynthetic Process Neuron Projection Development
Tagcloud ?		american artiodactyla assigned block blot cattle chr conservative conserved cow electrophoresis erbb2 hybrid hybridization localization localized means mink nf1 pepa pig prkca rara representatives sheep southern swine synteny umph2	analyse code crat ctsd ejaculated ejaculates elongating fertile fertilisation flna g6pd gapdh h3k9ac infertile intergenic mcf2l protamines semen semiquantitative sh3glb2 sox2 sperm spermatids spermatocytes spermatogenesis spermatogonia spermatozoa stk11ip testicular
Tagcloud (Difference) ?		american artiodactyla assigned block blot cattle chr conservative conserved cow electrophoresis erbb2 hybrid hybridization localization localized means mink nf1 pepa pig prkca rara representatives sheep southern swine synteny umph2	analyse code crat ctsd ejaculated ejaculates elongating fertile fertilisation flna g6pd gapdh h3k9ac infertile intergenic mcf2l protamines semen semiquantitative sh3glb2 sox2 sperm spermatids spermatocytes spermatogenesis spermatogonia spermatozoa stk11ip testicular
Tagcloud (Intersection) ?