TK1 and GLB1

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		TK1	GLB1
Gene Name		thymidine kinase 1, soluble	galactosidase, beta 1
Image
Gene Ontology Annotations	Cellular Component	Cytosol	Cytoplasm Vacuole Golgi Apparatus Lysosomal Lumen Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Thymidine Kinase Activity ATP Binding Zinc Ion Binding Nucleoside Kinase Activity Identical Protein Binding	Beta-galactosidase Activity Protein Binding Galactoside Binding
	Biological Process	Liver Development Nucleobase-containing Compound Metabolic Process Pyrimidine Nucleobase Metabolic Process Deoxyribonucleoside Monophosphate Biosynthetic Process Nucleotide Biosynthetic Process Response To Toxic Substance Skeletal Muscle Cell Proliferation Phosphorylation Response To Nutrient Levels Pyrimidine Nucleoside Salvage Small Molecule Metabolic Process Thymidine Metabolic Process Response To Copper Ion Digestive Tract Development Protein Homotetramerization Response To Cortisol Nucleobase-containing Small Molecule Metabolic Process Fetal Process Involved In Parturition DNA Biosynthetic Process	Carbohydrate Metabolic Process Glycosaminoglycan Catabolic Process Dolichol-linked Oligosaccharide Biosynthetic Process Sphingolipid Metabolic Process Glycosphingolipid Metabolic Process Pathogenesis Protein N-linked Glycosylation Via Asparagine Galactose Catabolic Process Glycosaminoglycan Metabolic Process Keratan Sulfate Metabolic Process Keratan Sulfate Catabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process Small Molecule Metabolic Process
Pathways		Pyrimidine salvage reactions Pyrimidine metabolism Metabolism of nucleotides	Metabolism of lipids and lipoproteins Keratan sulfate/keratin metabolism MPS I - Hurler syndrome MPS IX - Natowicz syndrome Glycosaminoglycan metabolism Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective CHST14 causes EDS, musculocontractural type Myoclonic epilepsy of Lafora Glycogen storage diseases MPS IIID - Sanfilippo syndrome D Defective CHST6 causes MCDC1 Defective ALG2 causes ALG2-CDG (CDG-1i) Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Keratan sulfate degradation Post-translational protein modification Defective ALG3 causes ALG3-CDG (CDG-1d) Defective EXT2 causes exostoses 2 Synthesis of substrates in N-glycan biosythesis Asparagine N-linked glycosylation MPS IV - Morquio syndrome A Sialic acid metabolism Defective MPDU1 causes MPDU1-CDG (CDG-1f) Metabolism of carbohydrates Diseases associated with N-glycosylation of proteins MPS VI - Maroteaux-Lamy syndrome MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type Heparan sulfate/heparin (HS-GAG) metabolism Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective SLC26A2 causes chondrodysplasias Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MOGS causes MOGS-CDG (CDG-2b) Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective PAPSS2 causes SEMD-PA Defective ALG9 causes ALG9-CDG (CDG-1l) MPS IIIA - Sanfilippo syndrome A Defective MAN1B1 causes MRT15 MPS IIIC - Sanfilippo syndrome C Defective ALG11 causes ALG11-CDG (CDG-1p) Sphingolipid metabolism Glycosphingolipid metabolism Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective ALG8 causes ALG8-CDG (CDG-1h) Defective ALG12 causes ALG12-CDG (CDG-1g) MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS MPS VII - Sly syndrome HS-GAG degradation
Drugs		Dithioerythritol Thymidine-5\'-Triphosphate
Diseases
GWAS			Atopic dermatitis ( 23042114) Hepatocellular carcinoma ( 21105107)
Protein-Protein Interactions		159 interactors: A1BG A2M AAMP ABHD4 ACTB ACTL6B ACTR1B ADAMTS10 ADD1 AGAP1 ALAS1 ALB APLP1 APP ARFGAP1 ASNA1 ATG16L2 ATP5B ATP6V1A ATXN3 BAG6 C14orf1 C19orf60 CARHSP1 CCDC115 CCDC90B CDC20 CDK1 CDK4 CDKN1A CENPB CHGB CLEC3B COL11A2 COL4A2 COL4A5 COPS6 CPNE6 CPSF3L CRIP2 CRMP1 CSAD DACT1 DALRD3 DCAF13 DDAH2 DEAF1 DMPK DOCK7 DRAP1 DUS2 DYNC1I1 EEF1A1 EIF3G EIF4A2 EIF6 EXT2 EZH2 F13A1 FAF1 FAM20C FBN3 FGB FLAD1 FST FZR1 GAPDH GDF9 GDI1 GLB1 GPCPD1 HADHB HERC3 HMGXB3 HSPBAP1 IER3IP1 IGHM IMMT INPP5K ITSN1 JADE1 JMJD1C KDM6B KIF21B KIF5A KLHL23 KLHL5 KMT2B LOC148413 LRIF1 MAGEA4 MAST2 MED31 METTL23 MKI67 MPP1 MPPED1 MRFAP1 MRPL37 MSH2 NEUROD2 NGFR NKIRAS2 NMT2 NRBP1 ODC1 PAAF1 PDE4DIP PKM PLD3 PLXNA3 PPP4C PROC PSME1 PTPN4 PTPRK QARS RBBP4 RBM48 RPA1 RPL13 RPS2 RUVBL1 RXRA SDF4 SEMA5B SEPT6 SETDB1 SEZ6L2 SMC5 SNX1 SP110 SULT1A3 SUMO3 TAF1C TCTEX1D2 THOC3 TIAM2 TLE1 TMSB4X TP53 TRIM46 TRMT2A TSC2 TTC38 TUBA1A TUBB2A TUBB3 TYK2 UNC119 UPF2 USP4 WDR18 WDR60 WDR73 WIZ ZBTB16 ZNF431 ZXDC	7 interactors: CSNK2B CTSA DNAJB1 FOS NEU1 PLK1 TK1
Entrez ID		7083	2720
HPRD ID		01771	01975
Ensembl ID		ENSG00000167900	ENSG00000170266
Uniprot IDs		P04183	P16278
PDB IDs		1W4R 1XBT 2ORV 2WVJ	3THC 3THD
Enriched GO Terms of Interacting Partners?		Cellular Metabolic Process Regulation Of Protein Metabolic Process Cellular Protein Metabolic Process Developmental Process Anatomical Structure Development System Development Regulation Of Cellular Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Multicellular Organismal Development Cellular Localization Metabolic Process Regulation Of Metabolic Process Organelle Organization Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Protein Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Catabolic Process RNA Metabolic Process Negative Regulation Of Cell Cycle Posttranscriptional Regulation Of Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Cellular Metabolic Process Cell Differentiation Platelet Degranulation Gene Expression Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Negative Regulation Of Mitotic Cell Cycle Cellular Process Biosynthetic Process Regulation Of Cell Cycle Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Cell Cycle Process Mitotic Cell Cycle Process Axon Guidance Chromatin Organization Viral Process Programmed Cell Death Negative Regulation Of Mitotic Cell Cycle Phase Transition Chromosome Organization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Organic Substance Mitotic Cell Cycle Cellular Response To Growth Factor Stimulus	Response To Toxic Substance Dolichol-linked Oligosaccharide Biosynthetic Process Glycosphingolipid Metabolic Process Fetal Process Involved In Parturition Protein N-linked Glycosylation Via Asparagine Protein N-linked Glycosylation Skeletal Muscle Cell Proliferation Activation Of APC-Cdc20 Complex Activity Glycolipid Metabolic Process Response To Glucocorticoid Sphingolipid Metabolic Process Response To Corticosteroid Positive Regulation Of Metabolic Process Phosphorylation Polar Body Extrusion After Meiotic Divisions Response To Temperature Stimulus Post-translational Protein Modification Response To Cortisol Chaperone Cofactor-dependent Protein Refolding Conditioned Taste Aversion Thymidine Metabolic Process Membrane Lipid Metabolic Process Activation Of Anaphase-promoting Complex Activity Meiotic Cytokinesis Response To Hormone Peptidyl-amino Acid Modification Positive Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Activin Receptor Signaling Pathway Deoxyribonucleoside Monophosphate Biosynthetic Process Regulation Of Binding Adiponectin-activated Signaling Pathway Metaphase/anaphase Transition Of Mitotic Cell Cycle Oligosaccharide Catabolic Process Pyrimidine Nucleoside Salvage Pyrimidine-containing Compound Salvage Cellular Metabolic Process Regulation Of Catalytic Activity Negative Regulation Of Inclusion Body Assembly Cellular Protein Metabolic Process Endothelial Tube Morphogenesis Response To Organic Substance Protein Localization To Chromatin Response To Metal Ion Protein Glycosylation Macromolecule Glycosylation Glycosylation Sleep Response To Gravity Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Chromosome Segregation
Tagcloud ?		american artiodactyla assigned block blot cattle chr conservative conserved cow electrophoresis erbb2 hybrid hybridization localization localized means mink nf1 pepa pig prkca rara representatives sheep southern swine synteny umph2	acy acy1 acylamino aminoacylase aminohydrolase approximate assignment autosomal chromosome chromosomes conserved electrophoretic eliminating galactosidase gangliosidosis gm1 hamster hybrids inbred linkage mammals map q21 segment segregating somatic tf transferrin translocations
Tagcloud (Difference) ?		american artiodactyla assigned block blot cattle chr conservative cow electrophoresis erbb2 hybrid hybridization localization localized means mink nf1 pepa pig prkca rara representatives sheep southern swine synteny umph2	acy acy1 acylamino aminoacylase aminohydrolase approximate assignment autosomal chromosome chromosomes electrophoretic eliminating galactosidase gangliosidosis gm1 hamster hybrids inbred linkage mammals map q21 segment segregating somatic tf transferrin translocations
Tagcloud (Intersection) ?		conserved