ALAS1 and JRK

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ALAS1	JRK
Description		5'-aminolevulinate synthase 1	Jrk helix-turn-helix protein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Cytosol Membrane	Nucleus Cytoplasm Ribonucleoprotein Complex
	Molecular Function	5-aminolevulinate Synthase Activity Protein Binding Transferase Activity Acyltransferase Activity Pyridoxal Phosphate Binding Identical Protein Binding	Nucleic Acid Binding DNA Binding MRNA Binding Protein Binding
	Biological Process	Response To Hypoxia Porphyrin-containing Compound Metabolic Process Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Heme A Biosynthetic Process Heme B Biosynthetic Process Response To Xenobiotic Stimulus Response To Herbicide Response To Nickel Cation Response To Nutrient Levels Response To Cobalt Ion Cellular Response To Insulin Stimulus Tetrapyrrole Biosynthetic Process Response To Gonadotropin Hemoglobin Biosynthetic Process Response To Ethanol Heme O Biosynthetic Process Erythrocyte Development Response To CAMP Response To Platinum Ion Response To Bile Acid	Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Heme biosynthesis PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Mitochondrial protein degradation
Drugs		Pyridoxal phosphate Pyridoxal phosphate Glycine
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Parkinson's disease ( 28892059) Schizophrenia ( 23974872)	Urinary tract infection frequency ( 28928442)
Interacting Genes		54 interacting genes: BCL7A C2orf42 C8orf33 CAP2 CCHCR1 CDC73 CDK5 CDKN1A CERK COBL EP400 FBXL8 FXR1 GNL3L GRXCR1 HSBP1L1 JRK KIF9 KLHL35 LONRF1 LRRC45 MTFR2 MTSS2 NUDT3 OXTR PIBF1 PIK3CB PLAU POLDIP2 PPL RAP1B RNF168 RTL8B SH2D4A SNRPB2 SNX20 STAMBP SUMO2 TCEA2 TEKT4 TK1 TMSB10 TMSB4X TMSB4XP1 TMSB4XP2 TMSB4XP6 TTC23 USP20 UTP14C WIPF1 ZFYVE26 ZMAT1 ZNF175 ZNF564	36 interacting genes: ALAS1 BYSL CATSPERT CCDC136 CCDC57 CDC37 CNKSR3 FAM161A FBXO17 GOLGA6L9 HSF2BP IFRD2 KDM1A KPNA6 LDOC1 LGALS14 MTUS2 PDZD4 PICK1 PRICKLE1 TFIP11 TPM4 TRIM23 TRIM41 TRIP10 TSGA10 TXK USP2 UTP14C ZBTB8A ZNF343 ZNF417 ZNF620 ZNF629 ZNF655 ZRANB1
Entrez ID		211	8629
HPRD ID		00505	04442
Ensembl ID		ENSG00000023330	ENSG00000234616
Uniprot IDs		B4DVA0 P13196 Q5JAM2	O75564
PDB IDs
Enriched GO Terms of Interacting Partners?		Actin Monomer Binding
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