ALAS1 and COBL

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ALAS1	COBL
Description		5'-aminolevulinate synthase 1	cordon-bleu WH2 repeat protein
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Cytosol Membrane	Ruffle Cytoplasm Cytoskeleton Actin Filament Plasma Membrane Cell Cortex Membrane Axon Dendrite Cell Projection Neuronal Cell Body Dendritic Growth Cone Axonal Growth Cone Perinuclear Region Of Cytoplasm Terminal Web
	Molecular Function	5-aminolevulinate Synthase Activity Protein Binding Transferase Activity Acyltransferase Activity Pyridoxal Phosphate Binding Identical Protein Binding	Actin Binding Actin Monomer Binding Protein Binding
	Biological Process	Response To Hypoxia Porphyrin-containing Compound Metabolic Process Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Heme A Biosynthetic Process Heme B Biosynthetic Process Response To Xenobiotic Stimulus Response To Herbicide Response To Nickel Cation Response To Nutrient Levels Response To Cobalt Ion Cellular Response To Insulin Stimulus Tetrapyrrole Biosynthetic Process Response To Gonadotropin Hemoglobin Biosynthetic Process Response To Ethanol Heme O Biosynthetic Process Erythrocyte Development Response To CAMP Response To Platinum Ion Response To Bile Acid	Embryonic Axis Specification Somite Specification Neural Tube Closure Liver Development Actin Cytoskeleton Organization Actin Filament Polymerization Notochord Development Floor Plate Development Digestive Tract Development Collateral Sprouting In Absence Of Injury Actin Filament Network Formation Positive Regulation Of Dendrite Development Positive Regulation Of Ruffle Assembly
Pathways		Heme biosynthesis PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Mitochondrial protein degradation
Drugs		Pyridoxal phosphate Pyridoxal phosphate Glycine
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Parkinson's disease ( 28892059) Schizophrenia ( 23974872)	Alzheimer's disease ( 33074286) Autoimmune traits (pleiotropy) ( 30572963) Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Cleft lip with or without cleft palate (maternal periconceptional vitamin use interaction) ( 29535761) Colorectal cancer x fine particulate matter exposure levels interaction ( 33338681) Fractures ( 30158200) Late-onset Alzheimer's disease ( 27770636) Macular thickness ( 30535121) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511) Refractive error ( 32231278) Squamous cell lung carcinoma ( 28604730) Type 1 diabetes ( 19430480) Urate levels in obese individuals ( 25811787) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 26480920) Wegener's granulomatosis ( 23740775)
Interacting Genes		54 interacting genes: BCL7A C2orf42 C8orf33 CAP2 CCHCR1 CDC73 CDK5 CDKN1A CERK COBL EP400 FBXL8 FXR1 GNL3L GRXCR1 HSBP1L1 JRK KIF9 KLHL35 LONRF1 LRRC45 MTFR2 MTSS2 NUDT3 OXTR PIBF1 PIK3CB PLAU POLDIP2 PPL RAP1B RNF168 RTL8B SH2D4A SNRPB2 SNX20 STAMBP SUMO2 TCEA2 TEKT4 TK1 TMSB10 TMSB4X TMSB4XP1 TMSB4XP2 TMSB4XP6 TTC23 USP20 UTP14C WIPF1 ZFYVE26 ZMAT1 ZNF175 ZNF564	2 interacting genes: ALAS1 NLGN3
Entrez ID		211	23242
HPRD ID		00505	10843
Ensembl ID		ENSG00000023330	ENSG00000106078
Uniprot IDs		B4DVA0 P13196 Q5JAM2	O75128
PDB IDs			4PL8
Enriched GO Terms of Interacting Partners?		Actin Monomer Binding	Heme O Biosynthetic Process Response To Herbicide Response To Cobalt Ion 5-aminolevulinate Synthase Activity Response To Nickel Cation Response To Bile Acid Response To Platinum Ion Heme A Biosynthetic Process Protoporphyrinogen IX Biosynthetic Process Hemoglobin Biosynthetic Process Heme B Biosynthetic Process Asymmetric, Glutamatergic, Excitatory Synapse Inhibitory Postsynaptic Potential Positive Regulation Of Glutamate Receptor Signaling Pathway Rhythmic Synaptic Transmission Postsynaptic Membrane Assembly Postsynaptic Membrane Organization Presynaptic Membrane Assembly Symmetric, GABA-ergic, Inhibitory Synapse Neuron To Neuron Synapse Presynaptic Membrane Organization Hemoglobin Metabolic Process Protoporphyrinogen IX Metabolic Process Regulation Of Respiratory Gaseous Exchange By Nervous System Process Regulation Of Glutamate Receptor Signaling Pathway Neurexin Family Protein Binding Presynapse Assembly Regulation Of Respiratory System Process Neuron Cell-cell Adhesion Presynapse Organization Vocalization Behavior Heme Biosynthetic Process Regulation Of Respiratory Gaseous Exchange Tetrapyrrole Biosynthetic Process Porphyrin-containing Compound Biosynthetic Process Response To Gonadotropin Erythrocyte Development Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Transmission, Glutamatergic Excitatory Synapse Heme Metabolic Process Synaptic Vesicle Endocytosis Porphyrin-containing Compound Metabolic Process Presynaptic Endocytosis Axon Extension Modulation Of Excitatory Postsynaptic Potential Pyridoxal Phosphate Binding Tetrapyrrole Metabolic Process Pigment Metabolic Process Social Behavior
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