TK1 and SDF4

Number of citations: 0 (PubMedID 21900206)
Data Source: BioGRID (two hybrid)

		TK1	SDF4
Name		thymidine kinase 1	stromal cell derived factor 4
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Cytoplasm Late Endosome Endoplasmic Reticulum Golgi Apparatus Golgi Lumen Plasma Membrane Membrane Bleb Cell Projection Extracellular Exosome
	Molecular Function	Nucleotide Binding Thymidine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Identical Protein Binding Metal Ion Binding	Calcium Ion Binding Protein Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Nucleobase-containing Compound Metabolic Process Deoxyribonucleoside Monophosphate Biosynthetic Process Thymidine Metabolic Process Thymidine Biosynthetic Process Protein Homotetramerization DNA Biosynthetic Process DNA Synthesis Involved In Mitotic DNA Replication	Exocytosis UV Protection Calcium-ion Regulated Exocytosis Cerebellum Development Fat Cell Differentiation Response To Ethanol Zymogen Granule Exocytosis Maintenance Of Synapse Structure
Pathways		G1/S-Specific Transcription Pyrimidine salvage	None
Drugs		Dithioerythritol Thymidine 5'-triphosphate	None
GWAS		Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Leukocyte telomere length ( 32109421 ) Mean corpuscular hemoglobin ( 27863252 32888494 ) Mean corpuscular volume ( 27863252 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Red cell distribution width ( 27863252 28957414 32888494 )	Blond vs. brown/black hair color ( 30531825 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Medication use (thyroid preparations) ( 31015401 )
Interacting Genes		166 interacting genes: A1BG A2M AAMP ABHD4 ACTB ACTL6B ACTR1B ADAMTS10 ADD1 AGAP1 ALAS1 ALB APLP1 APP ARFGAP1 ATG16L2 ATP5F1B ATP6V1A ATXN3 BAG6 BOLA2 BOLA2B CARHSP1 CCDC90B CDC20 CDK1 CDK4 CDKN1A CENPB CFTR CHGB CLEC3B COL11A2 COL4A2 COL4A5 COPS6 CPNE6 CRIP2 CRMP1 CSAD DACT1 DALRD3 DCAF13 DDAH2 DEAF1 DMPK DOCK7 DRAP1 DUS2 DYNC1I1 DYNC2I1 DYNLT2B EEF1A1 EIF3G EIF4A2 EIF6 ERG28 EXT2 EZH2 F13A1 FAF1 FAM20C FBN3 FGB FLAD1 FST FZR1 GAPDH GDF9 GDI1 GET3 GLB1 GPCPD1 HADHB HERC3 HMGXB3 HSPBAP1 IER3IP1 IGHM IMMT INPP5K INTS11 ITSN1 JADE1 JMJD1C KDM6B KIF21B KIF5A KLHL23 KLHL5 KMT2B LRIF1 MAGEA4 MAST2 MED31 METTL23 MKI67 MPP1 MPPED1 MRFAP1 MRPL20-AS1 MRPL37 MSH2 NEUROD2 NGFR NKIRAS2 NMT2 NRBP1 ODC1 PAAF1 PDE4DIP PJA1 PKM PLD3 PLXNA3 PPP4C PRMT1 PROC PSME1 PTPN4 PTPRK QARS1 RBBP4 RBM48 REX1BD RPA1 RPL13 RPS2 RUVBL1 RXRA SDF4 SEMA5B SEPTIN6 SETDB1 SEZ6L2 SMC5 SNX1 SP110 SULT1A3 SUMO2 SUMO3 TAF1C THOC3 TIAM2 TLE1 TMSB4X TP53 TRIM46 TRMT2A TSC2 TTC38 TUBA1A TUBB2A TUBB3 TYK2 UBC UNC119 UPF2 USP4 VMA22 WDR18 WDR73 WIZ ZBTB16 ZNF431 ZXDC	12 interacting genes: ANXA7 APP CDKN1A NR1I2 RAP1B RCC1 RPA2 SMN1 SNCA TK1 TTR ZNF512B
Entrez ID		7083	51150
HPRD ID		01771	13113
Ensembl ID		ENSG00000167900	ENSG00000078808
Uniprot IDs		A0A384MDV9 K7ERV3 K7ES52 P04183	A0A5F9UJX7 Q9BRK5
PDB IDs		1W4R 1XBT 2ORV 2WVJ	Not available
GO Terms Enriched among Interactors		Cytoplasm Macromolecule Metabolic Process Protein Metabolic Process Platelet Alpha Granule Lumen Chromatin Organization Blood Microparticle Negative Regulation Of Cell Cycle G1/S Phase Transition Chromatin Remodeling Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Extracellular Exosome Cytosol Regulation Of DNA Replication Regulation Of G1/S Transition Of Mitotic Cell Cycle Protein Binding Nucleoplasm Positive Regulation Of Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Transferase Activity Nuclear Matrix Regulation Of Protein Catabolic Process DNA Synthesis Involved In Mitotic DNA Replication Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Macromolecule Biosynthetic Process Chromosome, Telomeric Region Positive Regulation Of Protein Metabolic Process Cytoskeleton Negative Regulation Of Cell Cycle Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Protein Tag Activity Developmental Process Growth Cone Protein Modification Process Cellular Response To Norepinephrine Stimulus Response To Norepinephrine Mitotic DNA Damage Checkpoint Signaling Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Oocyte Growth	Regulation Of Presynapse Organization Regulation Of Long-term Neuronal Synaptic Plasticity Protein Tetramerization Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Presynapse Assembly Protein-containing Complex Molecular Function Activator Activity Regulation Of Neurotransmitter Uptake Protein Serine/threonine Kinase Binding Positive Regulation Of Reactive Oxygen Species Metabolic Process Cellular Response To Copper Ion Nuclear Body Mitotic G1/S Transition Checkpoint Signaling Mitotic G1 DNA Damage Checkpoint Signaling Negative Regulation Of MiRNA Transcription Amyloid Fibril Formation Microglial Cell Activation Leukocyte Activation Involved In Inflammatory Response Response To Copper Ion Regulation Of Mitotic Cell Cycle Negative Regulation Of Exocytosis Protein Sequestering Activity Protein Kinase Inhibitor Activity Amyloid-beta Complex Growth Cone Lamellipodium Protein Complex Oligomerization Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cellular Response To CAMP Synapse Organization Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Neuronal Synaptic Plasticity Regulation Of Cell Junction Assembly Macrophage Activation Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G1/S Phase Transition Mitotic DNA Damage Checkpoint Signaling Response To Metal Ion Acetylcholine Receptor Activator Activity Positive Regulation Of Phosphate Metabolic Process Response To Light Stimulus Regulation Of MiRNA Transcription Lipoprotein Particle Positive Regulation Of Protein Import Mitotic DNA Integrity Checkpoint Signaling