ALAS1 and GNL3L

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		ALAS1	GNL3L
Gene Name		5-aminolevulinate synthase 1	guanine nucleotide binding protein-like 3 (nucleolar)-like
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix	Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Membrane
	Molecular Function	5-aminolevulinate Synthase Activity Pyridoxal Phosphate Binding	GTPase Activity Protein Binding GTP Binding Poly(A) RNA Binding
	Biological Process	Porphyrin-containing Compound Metabolic Process Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Organelle Organization Mitochondrion Organization Cellular Lipid Metabolic Process Small Molecule Metabolic Process	Metabolic Process Ribosome Biogenesis
Pathways		PPARA activates gene expression Heme biosynthesis Organelle biogenesis and maintenance Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Metabolism of porphyrins Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis Mitochondrial biogenesis
Drugs		Pyridoxal Phosphate Glycine
Diseases
GWAS		Bipolar disorder ( 21926972)
Protein-Protein Interactions		40 interactors: BCL7A C2orf42 C8orf33 CCHCR1 CDC73 CDK5 CDKN1A CERK DUSP19 EP400 FAM127C GNL3L KLHL35 LONRF1 MTFR2 NUDT3 PIK3CB PLAU POLDIP2 PPL RAP1B SH2D4A SNX20 STAMBP SUMO2 TCEA2 TEKT4 TK1 TMSB10 TMSB4X TMSB4XP1 TMSB4XP2 TMSB4XP6 TTC23 USP20 WIPF1 ZFYVE26 ZMAT1 ZNF175 ZNF564	6 interactors: ADRB2 ALAS1 LDOC1 LZTS2 ROPN1 TERF1
Entrez ID		211	54552
HPRD ID		00505	06514
Ensembl ID		ENSG00000023330
Uniprot IDs		P13196 Q5JAM2	Q05DU1 Q9NVN8
PDB IDs
Enriched GO Terms of Interacting Partners?		Sequestering Of Actin Monomers Blood Coagulation Hemostasis Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity	Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Telomeric Loop Formation Age-dependent Telomere Shortening Vasodilation By Norepinephrine-epinephrine Involved In Regulation Of Systemic Arterial Blood Pressure Protein Complex Assembly Telomere Maintenance Via Telomere Shortening Negative Regulation Of Telomere Maintenance Via Telomerase Heat Generation Diet Induced Thermogenesis Mitotic Nuclear Division Replicative Cell Aging Protoporphyrinogen IX Biosynthetic Process Cellular Protein Complex Assembly Regulation Of Nuclear Cell Cycle DNA Replication Spindle Midzone Assembly Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Protoporphyrinogen IX Metabolic Process Microtubule Severing Positive Regulation Of Microtubule Polymerization Cell Division Negative Regulation Of Smooth Muscle Contraction Regulation Of Telomerase Activity Adrenergic Receptor Signaling Pathway Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Response To Dietary Excess Regulation Of Telomere Maintenance Negative Regulation Of Multicellular Organism Growth Cellular Component Assembly Negative Regulation Of Muscle Contraction RNA-dependent DNA Replication Negative Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of DNA Biosynthetic Process Temperature Homeostasis Heme Biosynthetic Process Activation Of Adenylate Cyclase Activity Regulation Of Microtubule Polymerization Endosome To Lysosome Transport Telomere Maintenance Via Telomere Lengthening Cellular Macromolecular Complex Assembly Vasodilation Mitotic Spindle Assembly Checkpoint Bone Resorption Negative Regulation Of Cell Proliferation Positive Regulation Of Adenylate Cyclase Activity Spindle Assembly Checkpoint
Tagcloud ?		adequate arf1 candidate eif2b1 fbxw2 genorm gusb housekeeping hprt1 hysterectomy ideal leiomyoma menopausal menstrual mrpl19 myometrial myometrium normalization normfinder phases proliferative pum1 regardless secretory softwares standards taqman trim27 ube2d2	60s appreciable biogenesis carrying collapse delays depth description faceted gnl2 homology impairments lethality ns nucleostemin obscure rescue rescues ribosome rrna stabilization surprisingly ultimately unexpected unrelated vertebrate vertebrates zebrafish
Tagcloud (Difference) ?		adequate arf1 candidate eif2b1 fbxw2 genorm gusb housekeeping hprt1 hysterectomy ideal leiomyoma menopausal menstrual mrpl19 myometrial myometrium normalization normfinder phases proliferative pum1 regardless secretory softwares standards taqman trim27 ube2d2	60s appreciable biogenesis carrying collapse delays depth description faceted gnl2 homology impairments lethality ns nucleostemin obscure rescue rescues ribosome rrna stabilization surprisingly ultimately unexpected unrelated vertebrate vertebrates zebrafish
Tagcloud (Intersection) ?