ALAS1 and TMSB4XP6

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		ALAS1	TMSB4XP6
Gene Name		5-aminolevulinate synthase 1	thymosin beta 4, X-linked pseudogene 6
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	5-aminolevulinate Synthase Activity Pyridoxal Phosphate Binding
	Biological Process	Porphyrin-containing Compound Metabolic Process Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Organelle Organization Mitochondrion Organization Cellular Lipid Metabolic Process Small Molecule Metabolic Process
Pathways		PPARA activates gene expression Heme biosynthesis Organelle biogenesis and maintenance Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Metabolism of porphyrins Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis Mitochondrial biogenesis
Drugs		Pyridoxal Phosphate Glycine
Diseases
GWAS		Bipolar disorder ( 21926972)
Protein-Protein Interactions		40 interactors: BCL7A C2orf42 C8orf33 CCHCR1 CDC73 CDK5 CDKN1A CERK DUSP19 EP400 FAM127C GNL3L KLHL35 LONRF1 MTFR2 NUDT3 PIK3CB PLAU POLDIP2 PPL RAP1B SH2D4A SNX20 STAMBP SUMO2 TCEA2 TEKT4 TK1 TMSB10 TMSB4X TMSB4XP1 TMSB4XP2 TMSB4XP6 TTC23 USP20 WIPF1 ZFYVE26 ZMAT1 ZNF175 ZNF564	3 interactors: ADAMTSL4 ALAS1 TRIM27
Entrez ID		211	7120
HPRD ID		00505	10275
Ensembl ID		ENSG00000023330
Uniprot IDs		P13196 Q5JAM2
PDB IDs
Enriched GO Terms of Interacting Partners?		Sequestering Of Actin Monomers Blood Coagulation Hemostasis Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity	Negative Regulation Of Interleukin-2 Secretion Negative Regulation Of Calcium Ion Import Interferon-gamma Secretion Protoporphyrinogen IX Biosynthetic Process Protein O-linked Fucosylation Protoporphyrinogen IX Metabolic Process Negative Regulation Of Viral Release From Host Cell Interferon-gamma Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of Viral Transcription Regulation Of Viral Release From Host Cell Regulation Of Calcium Ion Import Heme Biosynthetic Process Protein K63-linked Ubiquitination Fucosylation Cytokine Secretion Protein Trimerization Porphyrin-containing Compound Biosynthetic Process Negative Regulation Of Cytokine Secretion Negative Regulation Of Adaptive Immune Response Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Heme Metabolic Process Negative Regulation Of Calcium Ion Transport
Tagcloud ?		adequate arf1 candidate eif2b1 fbxw2 genorm gusb housekeeping hprt1 hysterectomy ideal leiomyoma menopausal menstrual mrpl19 myometrial myometrium normalization normfinder phases proliferative pum1 regardless secretory softwares standards taqman trim27 ube2d2
Tagcloud (Difference) ?		adequate arf1 candidate eif2b1 fbxw2 genorm gusb housekeeping hprt1 hysterectomy ideal leiomyoma menopausal menstrual mrpl19 myometrial myometrium normalization normfinder phases proliferative pum1 regardless secretory softwares standards taqman trim27 ube2d2
Tagcloud (Intersection) ?