ALAS1 and TMSB4XP6

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		ALAS1	TMSB4XP6
Description		5'-aminolevulinate synthase 1	TMSB4X pseudogene 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Cytosol Membrane
	Molecular Function	5-aminolevulinate Synthase Activity Protein Binding Transferase Activity Acyltransferase Activity Pyridoxal Phosphate Binding Identical Protein Binding
	Biological Process	Response To Hypoxia Porphyrin-containing Compound Metabolic Process Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Heme A Biosynthetic Process Heme B Biosynthetic Process Response To Xenobiotic Stimulus Response To Herbicide Response To Nickel Cation Response To Nutrient Levels Response To Cobalt Ion Cellular Response To Insulin Stimulus Tetrapyrrole Biosynthetic Process Response To Gonadotropin Hemoglobin Biosynthetic Process Response To Ethanol Heme O Biosynthetic Process Erythrocyte Development Response To CAMP Response To Platinum Ion Response To Bile Acid
Pathways		Heme biosynthesis PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Mitochondrial protein degradation
Drugs		Pyridoxal phosphate Pyridoxal phosphate Glycine
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Parkinson's disease ( 28892059) Schizophrenia ( 23974872)
Interacting Genes		54 interacting genes: BCL7A C2orf42 C8orf33 CAP2 CCHCR1 CDC73 CDK5 CDKN1A CERK COBL EP400 FBXL8 FXR1 GNL3L GRXCR1 HSBP1L1 JRK KIF9 KLHL35 LONRF1 LRRC45 MTFR2 MTSS2 NUDT3 OXTR PIBF1 PIK3CB PLAU POLDIP2 PPL RAP1B RNF168 RTL8B SH2D4A SNRPB2 SNX20 STAMBP SUMO2 TCEA2 TEKT4 TK1 TMSB10 TMSB4X TMSB4XP1 TMSB4XP2 TMSB4XP6 TTC23 USP20 UTP14C WIPF1 ZFYVE26 ZMAT1 ZNF175 ZNF564	3 interacting genes: ADAMTSL4 ALAS1 TRIM27
Entrez ID		211	7120
HPRD ID		00505	10275
Ensembl ID		ENSG00000023330
Uniprot IDs		B4DVA0 P13196 Q5JAM2
PDB IDs
Enriched GO Terms of Interacting Partners?		Actin Monomer Binding	Heme O Biosynthetic Process Hemoglobin Metabolic Process Response To Herbicide Response To Cobalt Ion 5-aminolevulinate Synthase Activity Response To Hypoxia Response To Nickel Cation Response To Bile Acid Response To Platinum Ion Heme A Biosynthetic Process Protoporphyrinogen IX Biosynthetic Process Protoporphyrinogen IX Metabolic Process Response To Decreased Oxygen Levels Hemoglobin Biosynthetic Process Developmental Process Heme B Biosynthetic Process Prostaglandin-I Synthase Activity Developmental Process Involved In Reproduction Hydroperoxy Icosatetraenoate Dehydratase Activity Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Phosphatidylinositol 3-kinase Inhibitor Activity Regulation Of Golgi Lumen Acidification Interstitial Matrix Pigment Cell Development Response To Oxygen Levels Reproductive Process Prostaglandin Biosynthetic Process Negative Regulation Of Nitric Oxide Biosynthetic Process NAD+ Biosynthetic Process Via The Salvage Pathway Cellular Response To Interleukin-6 Negative Regulation Of Viral Transcription Positive Regulation Of Actin Nucleation Sodium:proton Antiporter Activity Potassium:proton Antiporter Activity Prostanoid Biosynthetic Process Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Suppression Of Viral Release By Host Arp2/3 Complex-mediated Actin Nucleation
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