ALAS1 and UTP14C

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ALAS1	UTP14C
Description		5'-aminolevulinate synthase 1	UTP14C small subunit processome component
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Cytosol Membrane	Nucleus Nucleolus Cytosol Small-subunit Processome
	Molecular Function	5-aminolevulinate Synthase Activity Protein Binding Transferase Activity Acyltransferase Activity Pyridoxal Phosphate Binding Identical Protein Binding	Protein Binding
	Biological Process	Response To Hypoxia Porphyrin-containing Compound Metabolic Process Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Heme A Biosynthetic Process Heme B Biosynthetic Process Response To Xenobiotic Stimulus Response To Herbicide Response To Nickel Cation Response To Nutrient Levels Response To Cobalt Ion Cellular Response To Insulin Stimulus Tetrapyrrole Biosynthetic Process Response To Gonadotropin Hemoglobin Biosynthetic Process Response To Ethanol Heme O Biosynthetic Process Erythrocyte Development Response To CAMP Response To Platinum Ion Response To Bile Acid	RRNA Processing Spermatogenesis Cell Differentiation Ribosome Biogenesis Meiotic Cell Cycle
Pathways		Heme biosynthesis PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Mitochondrial protein degradation	rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
Drugs		Pyridoxal phosphate Pyridoxal phosphate Glycine
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Parkinson's disease ( 28892059) Schizophrenia ( 23974872)
Interacting Genes		54 interacting genes: BCL7A C2orf42 C8orf33 CAP2 CCHCR1 CDC73 CDK5 CDKN1A CERK COBL EP400 FBXL8 FXR1 GNL3L GRXCR1 HSBP1L1 JRK KIF9 KLHL35 LONRF1 LRRC45 MTFR2 MTSS2 NUDT3 OXTR PIBF1 PIK3CB PLAU POLDIP2 PPL RAP1B RNF168 RTL8B SH2D4A SNRPB2 SNX20 STAMBP SUMO2 TCEA2 TEKT4 TK1 TMSB10 TMSB4X TMSB4XP1 TMSB4XP2 TMSB4XP6 TTC23 USP20 UTP14C WIPF1 ZFYVE26 ZMAT1 ZNF175 ZNF564	33 interacting genes: ALAS1 BICD2 C8orf34 CARD10 CCDC57 CEP70 GCC1 GOLGA2 GOLGA6A HOOK1 HOOK2 JRK KANK2 KRT34 KRT40 LZTS2 MCC MEOX2 MTUS2 NAB2 PDE4DIP PIBF1 PRICKLE1 RABEP1 RINT1 RNF10 TEX11 TRAF1 TRAF2 TRIM27 TRIM54 TXLNA USP7
Entrez ID		211	9724
HPRD ID		00505	12346
Ensembl ID		ENSG00000023330	ENSG00000253797
Uniprot IDs		B4DVA0 P13196 Q5JAM2	Q5TAP6
PDB IDs
Enriched GO Terms of Interacting Partners?		Actin Monomer Binding	Microtubule Cytoskeleton Organization Cytoskeleton Organization Cytoskeleton Microtubule-based Process Centrosome Dynein Light Intermediate Chain Binding Cytoplasm Organelle Organization FHF Complex Microtubule Mitotic Spindle Assembly Protein Localization To Perinuclear Region Of Cytoplasm Microtubule Binding Thioesterase Binding Golgi Cis Cisterna Spindle Organization Cytoplasmic Microtubule Organization Regulation Of Microtubule Cytoskeleton Organization Vesicle-mediated Transport HOPS Complex Supramolecular Fiber Organization Cellular Component Assembly Regulation Of Cytoskeleton Organization Cytoskeleton-dependent Intracellular Transport Microtubule Organizing Center Organization Positive Regulation Of Protein Modification Process Mitotic Spindle Organization Spindle Assembly Microtubule Organizing Center Early Endosome To Late Endosome Transport Negative Regulation Of Autophagy Golgi Organization Microtubule Nucleation Intracellular Transport Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Organelle Organization Tumor Necrosis Factor Receptor Binding TORC2 Complex Disassembly Regulation Of Microtubule-based Process Cilium Assembly Meiotic Gene Conversion Primary Ureteric Bud Growth Anterior Visceral Endoderm Cell Migration Negative Regulation Of Cardiac Muscle Cell Myoblast Differentiation Polarized Secretion Of Basement Membrane Proteins In Epithelium Cell Trailing Edge Membraneless Organelle Assembly Golgi Vesicle Transport Microtubule Cytoskeleton Organization Involved In Mitosis
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