ALAS1 and TMSB10

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid, two hybrid)

		ALAS1	TMSB10
Description		5'-aminolevulinate synthase 1	thymosin beta 10
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Cytosol Membrane	Cytoplasm Cytoskeleton
	Molecular Function	5-aminolevulinate Synthase Activity Protein Binding Transferase Activity Acyltransferase Activity Pyridoxal Phosphate Binding Identical Protein Binding	Actin Binding Actin Monomer Binding Protein Binding Protein Sequestering Activity
	Biological Process	Response To Hypoxia Porphyrin-containing Compound Metabolic Process Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Heme A Biosynthetic Process Heme B Biosynthetic Process Response To Xenobiotic Stimulus Response To Herbicide Response To Nickel Cation Response To Nutrient Levels Response To Cobalt Ion Cellular Response To Insulin Stimulus Tetrapyrrole Biosynthetic Process Response To Gonadotropin Hemoglobin Biosynthetic Process Response To Ethanol Heme O Biosynthetic Process Erythrocyte Development Response To CAMP Response To Platinum Ion Response To Bile Acid	Actin Filament Organization Regulation Of Cell Migration
Pathways		Heme biosynthesis PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Mitochondrial protein degradation
Drugs		Pyridoxal phosphate Pyridoxal phosphate Glycine
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Parkinson's disease ( 28892059) Schizophrenia ( 23974872)
Interacting Genes		54 interacting genes: BCL7A C2orf42 C8orf33 CAP2 CCHCR1 CDC73 CDK5 CDKN1A CERK COBL EP400 FBXL8 FXR1 GNL3L GRXCR1 HSBP1L1 JRK KIF9 KLHL35 LONRF1 LRRC45 MTFR2 MTSS2 NUDT3 OXTR PIBF1 PIK3CB PLAU POLDIP2 PPL RAP1B RNF168 RTL8B SH2D4A SNRPB2 SNX20 STAMBP SUMO2 TCEA2 TEKT4 TK1 TMSB10 TMSB4X TMSB4XP1 TMSB4XP2 TMSB4XP6 TTC23 USP20 UTP14C WIPF1 ZFYVE26 ZMAT1 ZNF175 ZNF564	8 interacting genes: ALAS1 KRTAP9-2 POT1 SRPK2 TERF1 TERF2 TERF2IP TMOD1
Entrez ID		211	9168
HPRD ID		00505	01779
Ensembl ID		ENSG00000023330	ENSG00000034510
Uniprot IDs		B4DVA0 P13196 Q5JAM2	P63313
PDB IDs
Enriched GO Terms of Interacting Partners?		Actin Monomer Binding	Shelterin Complex Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Telomere Capping RNA-templated DNA Biosynthetic Process Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Telomeric D-loop Disassembly Telomeric Loop Disassembly Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization DNA Biosynthetic Process Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Chromosome Organization Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of DNA Recombination At Telomere Telomere Organization Negative Regulation Of DNA Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Chromosome, Telomeric Region Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Chromosome Organization Telomerase Activity Protection From Non-homologous End Joining At Telomere Positive Regulation Of DNA Metabolic Process Chromosome Negative Regulation Of Cellular Component Organization Regulation Of DNA Biosynthetic Process Double-stranded Telomeric DNA Binding Chromosome Organization Protein Localization To Chromosome, Telomeric Region Telomere Maintenance In Response To DNA Damage Regulation Of DNA Metabolic Process Positive Regulation Of Organelle Organization Regulation Of Organelle Organization Regulation Of DNA Repair Macromolecule Biosynthetic Process DNA Metabolic Process Organelle Organization Negative Regulation Of DNA Recombination Male Germ Cell Nucleus Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere
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