ALAS1 and PPL

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		ALAS1	PPL
Gene Name		5-aminolevulinate synthase 1	periplakin
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix	Nucleus Mitochondrion Cytoskeleton Plasma Membrane Desmosome Extracellular Vesicular Exosome
	Molecular Function	5-aminolevulinate Synthase Activity Pyridoxal Phosphate Binding	Structural Constituent Of Cytoskeleton Protein Binding
	Biological Process	Porphyrin-containing Compound Metabolic Process Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Organelle Organization Mitochondrion Organization Cellular Lipid Metabolic Process Small Molecule Metabolic Process	Keratinization
Pathways		PPARA activates gene expression Heme biosynthesis Organelle biogenesis and maintenance Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Metabolism of porphyrins Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis Mitochondrial biogenesis
Drugs		Pyridoxal Phosphate Glycine
Diseases
GWAS		Bipolar disorder ( 21926972)	Lung cancer-asbestos exposure interaction ( 22637743) Metabolite levels (HVA/MHPG ratio) ( 23319000)
Protein-Protein Interactions		40 interactors: BCL7A C2orf42 C8orf33 CCHCR1 CDC73 CDK5 CDKN1A CERK DUSP19 EP400 FAM127C GNL3L KLHL35 LONRF1 MTFR2 NUDT3 PIK3CB PLAU POLDIP2 PPL RAP1B SH2D4A SNX20 STAMBP SUMO2 TCEA2 TEKT4 TK1 TMSB10 TMSB4X TMSB4XP1 TMSB4XP2 TMSB4XP6 TTC23 USP20 WIPF1 ZFYVE26 ZMAT1 ZNF175 ZNF564	22 interactors: AHCYL1 AKT1 ALAS1 CASP6 CEP57L1 COL17A1 EVPL ITSN1 KAZN KRT8 OPRM1 PPHLN1 RAB3IP RALBP1 SKIL TRAF2 TRIM27 TSC22D4 UBC USP7 VIM ZSCAN1
Entrez ID		211	5493
HPRD ID		00505	04187
Ensembl ID		ENSG00000023330	ENSG00000118898
Uniprot IDs		P13196 Q5JAM2	O60437
PDB IDs
Enriched GO Terms of Interacting Partners?		Sequestering Of Actin Monomers Blood Coagulation Hemostasis Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity	Epithelial Cell Differentiation Epithelium Development Protein Trimerization Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Keratinization Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Execution Phase Of Apoptosis Keratinocyte Differentiation Tissue Development Epidermis Development Regulation Of Intracellular Signal Transduction Protein Homotrimerization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Response To Growth Factor Response To Food Positive Regulation Of Cell Death Apoptotic Signaling Pathway Glycogen Biosynthetic Process Developmental Process Epidermal Cell Differentiation Response To Cytokine Tumor Necrosis Factor-mediated Signaling Pathway Cell Differentiation Involved In Embryonic Placenta Development Cell Differentiation Anatomical Structure Development Protein K63-linked Ubiquitination Lens Fiber Cell Differentiation Positive Regulation Of Sodium Ion Transport Protein Polyubiquitination Regulation Of Ion Transmembrane Transport Cellular Polysaccharide Biosynthetic Process Positive Regulation Of Intracellular Signal Transduction Polysaccharide Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Signal Transduction Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Catalytic Activity Regulation Of Phosphorylation Negative Regulation Of Neuron Death Positive Regulation Of Phosphorylation Negative Regulation Of Ion Transmembrane Transport Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Organic Substance
Tagcloud ?		adequate arf1 candidate eif2b1 fbxw2 genorm gusb housekeeping hprt1 hysterectomy ideal leiomyoma menopausal menstrual mrpl19 myometrial myometrium normalization normfinder phases proliferative pum1 regardless secretory softwares standards taqman trim27 ube2d2	32p aug carboxyl codons dephosphorylation detergents digestion disposition doublet duck embo envelope ganem hepadnavirus hepadnaviruses immunoblots imply labelling morphogenesis myristic myristylation ostapchuk p35 phosphatases s1 s2 topological virion yielding
Tagcloud (Difference) ?		adequate arf1 candidate eif2b1 fbxw2 genorm gusb housekeeping hprt1 hysterectomy ideal leiomyoma menopausal menstrual mrpl19 myometrial myometrium normalization normfinder phases proliferative pum1 regardless secretory softwares standards taqman trim27 ube2d2	32p aug carboxyl codons dephosphorylation detergents digestion disposition doublet duck embo envelope ganem hepadnavirus hepadnaviruses immunoblots imply labelling morphogenesis myristic myristylation ostapchuk p35 phosphatases s1 s2 topological virion yielding
Tagcloud (Intersection) ?