TK1 and ATP5B

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		TK1	ATP5B
Gene Name		thymidine kinase 1, soluble	ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Nucleus Mitochondrion Mitochondrial Proton-transporting ATP Synthase Complex Mitochondrial Proton-transporting ATP Synthase, Catalytic Core Mitochondrial Matrix Plasma Membrane Cell Surface Membrane Mitochondrial Membrane Mitochondrial Nucleoid Extracellular Vesicular Exosome
	Molecular Function	Thymidine Kinase Activity ATP Binding Zinc Ion Binding Nucleoside Kinase Activity Identical Protein Binding	Transporter Activity Protein Binding ATP Binding ATPase Activity Transmembrane Transporter Activity MHC Class I Protein Binding Proton-transporting ATP Synthase Activity, Rotational Mechanism Proton-transporting ATPase Activity, Rotational Mechanism
	Biological Process	Liver Development Nucleobase-containing Compound Metabolic Process Pyrimidine Nucleobase Metabolic Process Deoxyribonucleoside Monophosphate Biosynthetic Process Nucleotide Biosynthetic Process Response To Toxic Substance Skeletal Muscle Cell Proliferation Phosphorylation Response To Nutrient Levels Pyrimidine Nucleoside Salvage Small Molecule Metabolic Process Thymidine Metabolic Process Response To Copper Ion Digestive Tract Development Protein Homotetramerization Response To Cortisol Nucleobase-containing Small Molecule Metabolic Process Fetal Process Involved In Parturition DNA Biosynthetic Process	Angiogenesis Osteoblast Differentiation Generation Of Precursor Metabolites And Energy Lipid Metabolic Process ATP Biosynthetic Process Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Organelle Organization Mitochondrion Organization ATP Hydrolysis Coupled Proton Transport Proton Transport Respiratory Electron Transport Chain Mitochondrial ATP Synthesis Coupled Proton Transport Cellular Metabolic Process Small Molecule Metabolic Process Regulation Of Intracellular PH
Pathways		Pyrimidine salvage reactions Pyrimidine metabolism Metabolism of nucleotides	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Organelle biogenesis and maintenance Mitochondrial protein import Transcriptional activation of mitochondrial biogenesis The citric acid (TCA) cycle and respiratory electron transport Formation of ATP by chemiosmotic coupling Mitochondrial biogenesis
Drugs		Dithioerythritol Thymidine-5\'-Triphosphate
Diseases
GWAS
Protein-Protein Interactions		159 interactors: A1BG A2M AAMP ABHD4 ACTB ACTL6B ACTR1B ADAMTS10 ADD1 AGAP1 ALAS1 ALB APLP1 APP ARFGAP1 ASNA1 ATG16L2 ATP5B ATP6V1A ATXN3 BAG6 C14orf1 C19orf60 CARHSP1 CCDC115 CCDC90B CDC20 CDK1 CDK4 CDKN1A CENPB CHGB CLEC3B COL11A2 COL4A2 COL4A5 COPS6 CPNE6 CPSF3L CRIP2 CRMP1 CSAD DACT1 DALRD3 DCAF13 DDAH2 DEAF1 DMPK DOCK7 DRAP1 DUS2 DYNC1I1 EEF1A1 EIF3G EIF4A2 EIF6 EXT2 EZH2 F13A1 FAF1 FAM20C FBN3 FGB FLAD1 FST FZR1 GAPDH GDF9 GDI1 GLB1 GPCPD1 HADHB HERC3 HMGXB3 HSPBAP1 IER3IP1 IGHM IMMT INPP5K ITSN1 JADE1 JMJD1C KDM6B KIF21B KIF5A KLHL23 KLHL5 KMT2B LOC148413 LRIF1 MAGEA4 MAST2 MED31 METTL23 MKI67 MPP1 MPPED1 MRFAP1 MRPL37 MSH2 NEUROD2 NGFR NKIRAS2 NMT2 NRBP1 ODC1 PAAF1 PDE4DIP PKM PLD3 PLXNA3 PPP4C PROC PSME1 PTPN4 PTPRK QARS RBBP4 RBM48 RPA1 RPL13 RPS2 RUVBL1 RXRA SDF4 SEMA5B SEPT6 SETDB1 SEZ6L2 SMC5 SNX1 SP110 SULT1A3 SUMO3 TAF1C TCTEX1D2 THOC3 TIAM2 TLE1 TMSB4X TP53 TRIM46 TRMT2A TSC2 TTC38 TUBA1A TUBB2A TUBB3 TYK2 UNC119 UPF2 USP4 WDR18 WDR60 WDR73 WIZ ZBTB16 ZNF431 ZXDC	22 interactors: ANXA7 APOA1 ATP5A1 ATP5C1 ATPAF1 ATPAF2 CDK4 CDKN1A FANCA GRB7 HMOX2 PIN1 PLG PSME3 RPP14 SMN1 SUMO4 TERT TK1 TRIM55 TRIM63 YWHAG
Entrez ID		7083	506
HPRD ID		01771	00044
Ensembl ID		ENSG00000167900	ENSG00000110955
Uniprot IDs		P04183	P06576
PDB IDs		1W4R 1XBT 2ORV 2WVJ
Enriched GO Terms of Interacting Partners?		Cellular Metabolic Process Regulation Of Protein Metabolic Process Cellular Protein Metabolic Process Developmental Process Anatomical Structure Development System Development Regulation Of Cellular Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Multicellular Organismal Development Cellular Localization Metabolic Process Regulation Of Metabolic Process Organelle Organization Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Protein Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Catabolic Process RNA Metabolic Process Negative Regulation Of Cell Cycle Posttranscriptional Regulation Of Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Cellular Metabolic Process Cell Differentiation Platelet Degranulation Gene Expression Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Negative Regulation Of Mitotic Cell Cycle Cellular Process Biosynthetic Process Regulation Of Cell Cycle Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Cell Cycle Process Mitotic Cell Cycle Process Axon Guidance Chromatin Organization Viral Process Programmed Cell Death Negative Regulation Of Mitotic Cell Cycle Phase Transition Chromosome Organization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Organic Substance Mitotic Cell Cycle Cellular Response To Growth Factor Stimulus	Response To Organic Cyclic Compound Organ Regeneration Response To Steroid Hormone Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Cell Cycle Arrest Mitochondrial ATP Synthesis Coupled Proton Transport Nucleoside Monophosphate Biosynthetic Process Response To Hormone Cellular Component Assembly Response To Organic Substance Response To Hyperoxia Response To Abiotic Stimulus Response To Glucocorticoid G1/S Transition Of Mitotic Cell Cycle Response To Stress ATP Synthesis Coupled Proton Transport Response To Corticosteroid Regulation Of Mitotic Cell Cycle Response To Toxic Substance Hemostasis ATP Biosynthetic Process Posttranscriptional Regulation Of Gene Expression Response To Lipid Regulation Of Cell Cycle Process Cellular Metabolic Process Negative Regulation Of Cell Adhesion Molecule Production Fetal Process Involved In Parturition Negative Regulation Of Production Of SiRNA Involved In RNA Interference Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Response To Stimulus Regulation Of Cell Cycle Phase Transition DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Regulation Of Cellular Protein Metabolic Process Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Positive Regulation Of Transferase Activity Positive Regulation Of Fibroblast Proliferation Regulation Of Body Fluid Levels Negative Regulation Of RNA Interference Skeletal Muscle Cell Proliferation Negative Regulation Of Interleukin-1 Beta Secretion Transcription, RNA-templated Platelet Degranulation Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Transferase Activity Cell Aging
Tagcloud ?		american artiodactyla assigned block blot cattle chr conservative conserved cow electrophoresis erbb2 hybrid hybridization localization localized means mink nf1 pepa pig prkca rara representatives sheep southern swine synteny umph2	1p13 1p36 5x10 6q16 7p14 8q21 affecting ajap1 apoa1bp c7orf10 candidate fhl5 fut9 loci locus matched meta migraine mmp16 near poorly stat6 subgroup susceptibility tbc1d7 trait tspan2 understood wide
Tagcloud (Difference) ?		american artiodactyla assigned block blot cattle chr conservative conserved cow electrophoresis erbb2 hybrid hybridization localization localized means mink nf1 pepa pig prkca rara representatives sheep southern swine synteny umph2	1p13 1p36 5x10 6q16 7p14 8q21 affecting ajap1 apoa1bp c7orf10 candidate fhl5 fut9 loci locus matched meta migraine mmp16 near poorly stat6 subgroup susceptibility tbc1d7 trait tspan2 understood wide
Tagcloud (Intersection) ?