ALAS1 and TTC23

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		ALAS1	TTC23
Gene Name		5-aminolevulinate synthase 1	tetratricopeptide repeat domain 23
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	5-aminolevulinate Synthase Activity Pyridoxal Phosphate Binding
	Biological Process	Porphyrin-containing Compound Metabolic Process Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Organelle Organization Mitochondrion Organization Cellular Lipid Metabolic Process Small Molecule Metabolic Process
Pathways		PPARA activates gene expression Heme biosynthesis Organelle biogenesis and maintenance Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Metabolism of porphyrins Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis Mitochondrial biogenesis
Drugs		Pyridoxal Phosphate Glycine
Diseases
GWAS		Bipolar disorder ( 21926972)
Protein-Protein Interactions		40 interactors: BCL7A C2orf42 C8orf33 CCHCR1 CDC73 CDK5 CDKN1A CERK DUSP19 EP400 FAM127C GNL3L KLHL35 LONRF1 MTFR2 NUDT3 PIK3CB PLAU POLDIP2 PPL RAP1B SH2D4A SNX20 STAMBP SUMO2 TCEA2 TEKT4 TK1 TMSB10 TMSB4X TMSB4XP1 TMSB4XP2 TMSB4XP6 TTC23 USP20 WIPF1 ZFYVE26 ZMAT1 ZNF175 ZNF564	22 interactors: ALAS1 APP BHLHE40 CCNDBP1 CNTROB CREBZF GOLGA2 HTT KRT31 KRT40 KRTAP10-3 LDOC1 LZTS2 MAGED1 MDFI PNMA5 SPAG5 SSX2IP TADA2A TRIM10 TRIM54 ZDHHC17
Entrez ID		211	64927
HPRD ID		00505	07777
Ensembl ID		ENSG00000023330	ENSG00000103852
Uniprot IDs		P13196 Q5JAM2	Q5W5X9
PDB IDs
Enriched GO Terms of Interacting Partners?		Sequestering Of Actin Monomers Blood Coagulation Hemostasis Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity	Microtubule-based Process Mitotic Cell Cycle Microtubule Cytoskeleton Organization Cell Cycle Microtubule-based Transport Mitotic Cell Cycle Process Cytoskeleton-dependent Intracellular Transport Circadian Rhythm Axon Cargo Transport Neural Plate Formation Mating Neuron Apoptotic Process Regulation Of Binding Visual Learning Cell Cycle Process Visual Behavior Neuron Death Synaptic Growth At Neuromuscular Junction Serotonin Uptake Lactate Biosynthetic Process From Pyruvate Cytoskeleton Organization Rhythmic Process Negative Regulation Of Cell Proliferation Circadian Regulation Of Gene Expression Negative Regulation Of Protein Localization To Nucleus Microtubule-based Movement Mitotic Nuclear Division Associative Learning Negative Regulation Of Cerebellar Granule Cell Precursor Proliferation Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Collateral Sprouting In Absence Of Injury Regulation Of Protein Phosphatase Type 2A Activity Response To Light Stimulus Negative Regulation Of Binding Regulation Of Circadian Rhythm Centrosome Organization Quinolinate Biosynthetic Process Negative Regulation Of Synaptic Transmission, Dopaminergic Cytokinesis Positive Regulation Of Intracellular Signal Transduction Microtubule Organizing Center Organization Regulation Of Tubulin Deacetylation Collateral Sprouting Axon Midline Choice Point Recognition Lactate Biosynthetic Process
Tagcloud ?		adequate arf1 candidate eif2b1 fbxw2 genorm gusb housekeeping hprt1 hysterectomy ideal leiomyoma menopausal menstrual mrpl19 myometrial myometrium normalization normfinder phases proliferative pum1 regardless secretory softwares standards taqman trim27 ube2d2
Tagcloud (Difference) ?		adequate arf1 candidate eif2b1 fbxw2 genorm gusb housekeeping hprt1 hysterectomy ideal leiomyoma menopausal menstrual mrpl19 myometrial myometrium normalization normfinder phases proliferative pum1 regardless secretory softwares standards taqman trim27 ube2d2
Tagcloud (Intersection) ?