ALAS1 and USP20

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		ALAS1	USP20
Gene Name		5-aminolevulinate synthase 1	ubiquitin specific peptidase 20
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix	Centrosome Perinuclear Region Of Cytoplasm
	Molecular Function	5-aminolevulinate Synthase Activity Pyridoxal Phosphate Binding	G-protein Coupled Receptor Binding Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding Zinc Ion Binding
	Biological Process	Porphyrin-containing Compound Metabolic Process Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Organelle Organization Mitochondrion Organization Cellular Lipid Metabolic Process Small Molecule Metabolic Process	Endocytosis Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Protein Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination
Pathways		PPARA activates gene expression Heme biosynthesis Organelle biogenesis and maintenance Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Metabolism of porphyrins Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis Mitochondrial biogenesis
Drugs		Pyridoxal Phosphate Glycine
Diseases
GWAS		Bipolar disorder ( 21926972)
Protein-Protein Interactions		40 interactors: BCL7A C2orf42 C8orf33 CCHCR1 CDC73 CDK5 CDKN1A CERK DUSP19 EP400 FAM127C GNL3L KLHL35 LONRF1 MTFR2 NUDT3 PIK3CB PLAU POLDIP2 PPL RAP1B SH2D4A SNX20 STAMBP SUMO2 TCEA2 TEKT4 TK1 TMSB10 TMSB4X TMSB4XP1 TMSB4XP2 TMSB4XP6 TTC23 USP20 WIPF1 ZFYVE26 ZMAT1 ZNF175 ZNF564	20 interactors: ALAS1 BEND5 BEND7 CCDC36 DIO2 FATE1 HIF1A MAGEA11 MDFI PJA1 PLA2G2A PRKCI RAD17 SPRY2 TRIM23 USP15 USP21 USP28 VAPB VHL
Entrez ID		211	10868
HPRD ID		00505	07505
Ensembl ID		ENSG00000023330	ENSG00000136878
Uniprot IDs		P13196 Q5JAM2	Q9Y2K6
PDB IDs
Enriched GO Terms of Interacting Partners?		Sequestering Of Actin Monomers Blood Coagulation Hemostasis Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity	Protein Deubiquitination Protein Modification By Small Protein Removal Cellular Metabolic Process Histone Deubiquitination Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Stress Regulation Of Proteasomal Protein Catabolic Process Localization Within Membrane Protein Catabolic Process Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Proteasomal Protein Catabolic Process Regulation Of DNA-templated Transcription In Response To Stress Negative Regulation By Host Of Viral Release From Host Cell Neural Fold Elevation Formation Embryonic Organ Morphogenesis Regulation Of Nitrogen Compound Metabolic Process Membrane Budding Histone H2B Conserved C-terminal Lysine Deubiquitination Elastin Metabolic Process Negative Regulation By Virus Of Viral Protein Levels In Host Cell Negative Regulation By Host Of Viral Genome Replication Positive Regulation By Host Of Viral Release From Host Cell Thyroid Hormone Catabolic Process Response To Interleukin-1 Regulation Of Cell Proliferation Positive Regulation Of Cell Differentiation Regulation Of Protein Catabolic Process Cellular Response To Hypoxia Cellular Response To Stimulus Cellular Response To Decreased Oxygen Levels Positive Regulation Of Catalytic Activity Cellular Protein Modification Process Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Chemokine-mediated Signaling Pathway Vascular Endothelial Growth Factor Production Negative Regulation Of Apoptotic Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Programmed Cell Death Cellular Protein Metabolic Process Establishment Of Cell Polarity Cellular Response To Oxygen Levels Response To Stimulus Protein Metabolic Process Embryonic Placenta Development
Tagcloud ?		adequate arf1 candidate eif2b1 fbxw2 genorm gusb housekeeping hprt1 hysterectomy ideal leiomyoma menopausal menstrual mrpl19 myometrial myometrium normalization normfinder phases proliferative pum1 regardless secretory softwares standards taqman trim27 ube2d2	ablated adrenergic arrestin ars betaar blocker carvedilol desensitization deubiquitinases e3 endogenously flag hek interacted internalized itinerary ligase lysosomal machineries march2 proteomics recruit recycling serves stabilized ubiquitinated ubiquitination usp33 vsmcs
Tagcloud (Difference) ?		adequate arf1 candidate eif2b1 fbxw2 genorm gusb housekeeping hprt1 hysterectomy ideal leiomyoma menopausal menstrual mrpl19 myometrial myometrium normalization normfinder phases proliferative pum1 regardless secretory softwares standards taqman trim27 ube2d2	ablated adrenergic arrestin ars betaar blocker carvedilol desensitization deubiquitinases e3 endogenously flag hek interacted internalized itinerary ligase lysosomal machineries march2 proteomics recruit recycling serves stabilized ubiquitinated ubiquitination usp33 vsmcs
Tagcloud (Intersection) ?