TK1 and KDM6B

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		TK1	KDM6B
Description		thymidine kinase 1	lysine demethylase 6B
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Nucleoplasm MLL3/4 Complex
	Molecular Function	Nucleotide Binding Thymidine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Identical Protein Binding Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Binding Protein Binding Beta-catenin Binding Oxidoreductase Activity Chromatin DNA Binding Histone Demethylase Activity Sequence-specific DNA Binding Metal Ion Binding Dioxygenase Activity Histone H3K27me2/H3K27me3 Demethylase Activity
	Biological Process	Nucleobase-containing Compound Metabolic Process Deoxyribonucleoside Monophosphate Biosynthetic Process Thymidine Metabolic Process Thymidine Biosynthetic Process Protein Homotetramerization DNA Biosynthetic Process DNA Synthesis Involved In Mitotic DNA Replication	Inflammatory Response To Antigenic Stimulus Chromatin Organization Chromatin Remodeling Inflammatory Response Heart Development Regulation Of Gene Expression Response To Activity Hippocampus Development Cell Fate Commitment Endothelial Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Mesodermal Cell Differentiation Cardiac Muscle Cell Differentiation Response To Fungicide Cellular Response To Hydrogen Peroxide Positive Regulation Of Cold-induced Thermogenesis
Pathways		G1/S-Specific Transcription Pyrimidine salvage	Oxidative Stress Induced Senescence HDMs demethylate histones Chromatin modifications during the maternal to zygotic transition (MZT)
Drugs		Dithioerythritol Thymidine 5'-triphosphate
Diseases
GWAS		Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Leukocyte telomere length ( 32109421) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 27863252 28957414 32888494)	Alcohol consumption (drinks per week) ( 30643258) Brain morphology (MOSTest) ( 32665545) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Granulocyte percentage of myeloid white cells ( 27863252) Height ( 29782485 25429064) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Monocyte percentage of white cells ( 27863252 32888494) Neutrophil count ( 32888494) Plateletcrit ( 32888494) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 30578418) White blood cell count ( 32888494)
Interacting Genes		166 interacting genes: A1BG A2M AAMP ABHD4 ACTB ACTL6B ACTR1B ADAMTS10 ADD1 AGAP1 ALAS1 ALB APLP1 APP ARFGAP1 ATG16L2 ATP5F1B ATP6V1A ATXN3 BAG6 BOLA2 BOLA2B CARHSP1 CCDC90B CDC20 CDK1 CDK4 CDKN1A CENPB CFTR CHGB CLEC3B COL11A2 COL4A2 COL4A5 COPS6 CPNE6 CRIP2 CRMP1 CSAD DACT1 DALRD3 DCAF13 DDAH2 DEAF1 DMPK DOCK7 DRAP1 DUS2 DYNC1I1 DYNC2I1 DYNLT2B EEF1A1 EIF3G EIF4A2 EIF6 ERG28 EXT2 EZH2 F13A1 FAF1 FAM20C FBN3 FGB FLAD1 FST FZR1 GAPDH GDF9 GDI1 GET3 GLB1 GPCPD1 HADHB HERC3 HMGXB3 HSPBAP1 IER3IP1 IGHM IMMT INPP5K INTS11 ITSN1 JADE1 JMJD1C KDM6B KIF21B KIF5A KLHL23 KLHL5 KMT2B LRIF1 MAGEA4 MAST2 MED31 METTL23 MKI67 MPP1 MPPED1 MRFAP1 MRPL20-AS1 MRPL37 MSH2 NEUROD2 NGFR NKIRAS2 NMT2 NRBP1 ODC1 PAAF1 PDE4DIP PJA1 PKM PLD3 PLXNA3 PPP4C PRMT1 PROC PSME1 PTPN4 PTPRK QARS1 RBBP4 RBM48 REX1BD RPA1 RPL13 RPS2 RUVBL1 RXRA SDF4 SEMA5B SEPTIN6 SETDB1 SEZ6L2 SMC5 SNX1 SP110 SULT1A3 SUMO2 SUMO3 TAF1C THOC3 TIAM2 TLE1 TMSB4X TP53 TRIM46 TRMT2A TSC2 TTC38 TUBA1A TUBB2A TUBB3 TYK2 UBC UNC119 UPF2 USP4 VMA22 WDR18 WDR73 WIZ ZBTB16 ZNF431 ZXDC	6 interacting genes: CREBBP CSNK2B H3C1 PRMT2 TK1 TSPYL2
Entrez ID		7083	23135
HPRD ID		01771	18983
Ensembl ID		ENSG00000167900	ENSG00000132510
Uniprot IDs		A0A384MDV9 K7ERV3 K7ES52 P04183	O15054
PDB IDs		1W4R 1XBT 2ORV 2WVJ	2XUE 2XXZ 4ASK 5FP3 5OY3 6F6D
Enriched GO Terms of Interacting Partners?		Cytoplasm Macromolecule Metabolic Process Protein Metabolic Process Platelet Alpha Granule Lumen Chromatin Organization Blood Microparticle Negative Regulation Of Cell Cycle G1/S Phase Transition Chromatin Remodeling Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Extracellular Exosome Cytosol Regulation Of DNA Replication Regulation Of G1/S Transition Of Mitotic Cell Cycle Protein Binding Nucleoplasm Positive Regulation Of Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Transferase Activity Nuclear Matrix Regulation Of Protein Catabolic Process DNA Synthesis Involved In Mitotic DNA Replication Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Macromolecule Biosynthetic Process Chromosome, Telomeric Region Positive Regulation Of Protein Metabolic Process Cytoskeleton Negative Regulation Of Cell Cycle Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Protein Tag Activity Developmental Process Growth Cone Protein Modification Process Cellular Response To Norepinephrine Stimulus Response To Norepinephrine Mitotic DNA Damage Checkpoint Signaling Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Oocyte Growth	Chromatin Remodeling Protein-containing Complex Organization Protein-containing Complex Assembly Chromatin Organization Chromatin Binding Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Histone H3K27 Acetyltransferase Activity Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Component Assembly Peptide Lactyltransferase (CoA-dependent) Activity Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Histone H3R8 Methyltransferase Activity Nuclear Progesterone Receptor Binding DNA Synthesis Involved In Mitotic DNA Replication Thymidine Kinase Activity Nucleosome Assembly Nucleosome Organization MRF Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Release From Viral Latency Thymidine Biosynthetic Process Protein-DNA Complex Assembly Positive Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Viral Life Cycle Protein-arginine Omega-N Asymmetric Methyltransferase Activity Thymidine Metabolic Process RDNA Binding Nucleus Adiponectin-activated Signaling Pathway Nucleoplasm Protein-arginine N-methyltransferase Activity Deoxyribonucleoside Monophosphate Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase I Peroxisome Proliferator Activated Receptor Binding Transcription Coactivator Activity N-terminal Protein Amino Acid Acetylation Chromatin Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Endothelial Tube Morphogenesis Peptidyl-lysine Acetylation Pyrimidine Nucleoside Metabolic Process Regulation Of Cellular Response To Heat Protein Kinase Regulator Activity Nuclear Retinoic Acid Receptor Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Cycle Acetyltransferase Activity Cellular Response To Lectin
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