ALAS1 and TMSB4XP1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		ALAS1	TMSB4XP1
Description		5'-aminolevulinate synthase 1	TMSB4X pseudogene 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Cytosol Membrane
	Molecular Function	5-aminolevulinate Synthase Activity Protein Binding Transferase Activity Acyltransferase Activity Pyridoxal Phosphate Binding Identical Protein Binding
	Biological Process	Response To Hypoxia Porphyrin-containing Compound Metabolic Process Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Heme A Biosynthetic Process Heme B Biosynthetic Process Response To Xenobiotic Stimulus Response To Herbicide Response To Nickel Cation Response To Nutrient Levels Response To Cobalt Ion Cellular Response To Insulin Stimulus Tetrapyrrole Biosynthetic Process Response To Gonadotropin Hemoglobin Biosynthetic Process Response To Ethanol Heme O Biosynthetic Process Erythrocyte Development Response To CAMP Response To Platinum Ion Response To Bile Acid
Pathways		Heme biosynthesis PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Mitochondrial protein degradation
Drugs		Pyridoxal phosphate Pyridoxal phosphate Glycine
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Parkinson's disease ( 28892059) Schizophrenia ( 23974872)
Interacting Genes		54 interacting genes: BCL7A C2orf42 C8orf33 CAP2 CCHCR1 CDC73 CDK5 CDKN1A CERK COBL EP400 FBXL8 FXR1 GNL3L GRXCR1 HSBP1L1 JRK KIF9 KLHL35 LONRF1 LRRC45 MTFR2 MTSS2 NUDT3 OXTR PIBF1 PIK3CB PLAU POLDIP2 PPL RAP1B RNF168 RTL8B SH2D4A SNRPB2 SNX20 STAMBP SUMO2 TCEA2 TEKT4 TK1 TMSB10 TMSB4X TMSB4XP1 TMSB4XP2 TMSB4XP6 TTC23 USP20 UTP14C WIPF1 ZFYVE26 ZMAT1 ZNF175 ZNF564	3 interacting genes: ACTB ALAS1 LDOC1
Entrez ID		211	7115
HPRD ID		00505	10271
Ensembl ID		ENSG00000023330
Uniprot IDs		B4DVA0 P13196 Q5JAM2
PDB IDs
Enriched GO Terms of Interacting Partners?		Actin Monomer Binding	Cellular Response To Oxygen-containing Compound Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Regulation Of Norepinephrine Uptake 5-aminolevulinate Synthase Activity Response To Nickel Cation Transporter Regulator Activity BBAF Complex Tat Protein Binding Structural Constituent Of Postsynaptic Actin Cytoskeleton Nitric-oxide Synthase Regulator Activity Postsynaptic Actin Cytoskeleton Regulation Of Transepithelial Transport Protein Localization To Adherens Junction Dense Body Morphogenesis Of A Polarized Epithelium Heme O Biosynthetic Process Response To Herbicide Response To Cobalt Ion Response To Bile Acid Response To Platinum Ion Heme A Biosynthetic Process Protoporphyrinogen IX Biosynthetic Process Hemoglobin Biosynthetic Process Heme B Biosynthetic Process Maternal Placenta Development Maternal Process Involved In Parturition Cellular Response To Muramyl Dipeptide Hemoglobin Metabolic Process Protoporphyrinogen IX Metabolic Process Nitric-oxide Synthase Binding Brahma Complex Apical Protein Localization RSC-type Complex Adherens Junction Assembly NpBAF Complex GBAF Complex NBAF Complex Postsynaptic Actin Cytoskeleton Organization Protein Localization To Cell-cell Junction Calyx Of Held Postsynaptic Cytoskeleton Organization Response To Muramyl Dipeptide Heme Biosynthetic Process Regulation Of Synaptic Vesicle Endocytosis Tetrapyrrole Biosynthetic Process Porphyrin-containing Compound Biosynthetic Process Regulation Of Nucleotide-excision Repair Apical Junction Complex Cortical Cytoskeleton
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