ALAS1 and POLDIP2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		ALAS1	POLDIP2
Gene Name		5-aminolevulinate synthase 1	polymerase (DNA-directed), delta interacting protein 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix	Nucleus Mitochondrion Mitochondrial Nucleoid
	Molecular Function	5-aminolevulinate Synthase Activity Pyridoxal Phosphate Binding	DNA Binding
	Biological Process	Porphyrin-containing Compound Metabolic Process Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Organelle Organization Mitochondrion Organization Cellular Lipid Metabolic Process Small Molecule Metabolic Process	Mitochondrion Morphogenesis
Pathways		PPARA activates gene expression Heme biosynthesis Organelle biogenesis and maintenance Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Metabolism of porphyrins Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis Mitochondrial biogenesis
Drugs		Pyridoxal Phosphate Glycine
Diseases
GWAS		Bipolar disorder ( 21926972)
Protein-Protein Interactions		40 interactors: BCL7A C2orf42 C8orf33 CCHCR1 CDC73 CDK5 CDKN1A CERK DUSP19 EP400 FAM127C GNL3L KLHL35 LONRF1 MTFR2 NUDT3 PIK3CB PLAU POLDIP2 PPL RAP1B SH2D4A SNX20 STAMBP SUMO2 TCEA2 TEKT4 TK1 TMSB10 TMSB4X TMSB4XP1 TMSB4XP2 TMSB4XP6 TTC23 USP20 WIPF1 ZFYVE26 ZMAT1 ZNF175 ZNF564	14 interactors: ALAS1 APP ASCC2 CPE HDAC6 MAD2L2 MTUS2 PCNA PDPK1 POLD2 POLN REV1 SELENBP1 TAB1
Entrez ID		211	26073
HPRD ID		00505	17874
Ensembl ID		ENSG00000023330	ENSG00000004142
Uniprot IDs		P13196 Q5JAM2	Q9Y2S7
PDB IDs
Enriched GO Terms of Interacting Partners?		Sequestering Of Actin Monomers Blood Coagulation Hemostasis Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity	Translesion Synthesis Postreplication Repair DNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Cellular Response To Stress Nitrogen Compound Metabolic Process DNA Repair DNA Replication Response To Stress Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA-dependent DNA Replication Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication Cellular Response To DNA Damage Stimulus Nuclear DNA Replication Telomere Maintenance Via Recombination Mitotic Recombination DNA Strand Elongation Involved In DNA Replication Nucleobase-containing Compound Metabolic Process DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening DNA Metabolic Process Cellular Macromolecule Biosynthetic Process Biosynthetic Process Macromolecule Biosynthetic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Transcription-coupled Nucleotide-excision Repair DNA Recombination Cellular Metabolic Process Cellular Response To Stimulus Mismatch Repair Base-excision Repair Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Positive Regulation Of Deoxyribonuclease Activity Hsp90 Deacetylation Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Proteolysis Telomere Maintenance Regulation Of Catalytic Activity Negative Regulation Of Protein Processing Negative Regulation Of Protein Metabolic Process Positive Regulation Of Chaperone-mediated Protein Complex Assembly Leading Strand Elongation Synaptic Growth At Neuromuscular Junction Polyubiquitinated Misfolded Protein Transport Nucleotide-excision Repair Regulation Of Protein Processing Positive Regulation Of Cellular Metabolic Process
Tagcloud ?		adequate arf1 candidate eif2b1 fbxw2 genorm gusb housekeeping hprt1 hysterectomy ideal leiomyoma menopausal menstrual mrpl19 myometrial myometrium normalization normfinder phases proliferative pum1 regardless secretory softwares standards taqman trim27 ube2d2	atherosclerosis cdk1 curves cyclina2 delta die doubling e2f elongation embryos heterozygous homozygous lc3b mefs nox4 originally p21cip1 partner passage pcna proliferating restenosis s20 sirt1 sv40 transfection unaffected underline understudied
Tagcloud (Difference) ?		adequate arf1 candidate eif2b1 fbxw2 genorm gusb housekeeping hprt1 hysterectomy ideal leiomyoma menopausal menstrual mrpl19 myometrial myometrium normalization normfinder phases proliferative pum1 regardless secretory softwares standards taqman trim27 ube2d2	atherosclerosis cdk1 curves cyclina2 delta die doubling e2f elongation embryos heterozygous homozygous lc3b mefs nox4 originally p21cip1 partner passage pcna proliferating restenosis s20 sirt1 sv40 transfection unaffected underline understudied
Tagcloud (Intersection) ?