TK1 and CLEC3B

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		TK1	CLEC3B
Description		thymidine kinase 1	C-type lectin domain family 3 member B
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Granular Component Extracellular Region Extracellular Space Cytoplasm Extracellular Matrix Platelet Dense Granule Lumen Extracellular Exosome
	Molecular Function	Nucleotide Binding Thymidine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Identical Protein Binding Metal Ion Binding	Calcium Ion Binding Heparin Binding Carbohydrate Binding Kringle Domain Binding
	Biological Process	Nucleobase-containing Compound Metabolic Process Deoxyribonucleoside Monophosphate Biosynthetic Process Thymidine Metabolic Process Thymidine Biosynthetic Process Protein Homotetramerization DNA Biosynthetic Process DNA Synthesis Involved In Mitotic DNA Replication	Ossification Positive Regulation Of Plasminogen Activation Bone Mineralization
Pathways		G1/S-Specific Transcription Pyrimidine salvage	Platelet degranulation
Drugs		Dithioerythritol Thymidine 5'-triphosphate	Tenecteplase Lanoteplase Copper
Diseases
GWAS		Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Leukocyte telomere length ( 32109421) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 27863252 28957414 32888494)	Acne (severe) ( 24927181) Alzheimer's disease ( 33654092) Blood protein levels ( 30072576)
Interacting Genes		166 interacting genes: A1BG A2M AAMP ABHD4 ACTB ACTL6B ACTR1B ADAMTS10 ADD1 AGAP1 ALAS1 ALB APLP1 APP ARFGAP1 ATG16L2 ATP5F1B ATP6V1A ATXN3 BAG6 BOLA2 BOLA2B CARHSP1 CCDC90B CDC20 CDK1 CDK4 CDKN1A CENPB CFTR CHGB CLEC3B COL11A2 COL4A2 COL4A5 COPS6 CPNE6 CRIP2 CRMP1 CSAD DACT1 DALRD3 DCAF13 DDAH2 DEAF1 DMPK DOCK7 DRAP1 DUS2 DYNC1I1 DYNC2I1 DYNLT2B EEF1A1 EIF3G EIF4A2 EIF6 ERG28 EXT2 EZH2 F13A1 FAF1 FAM20C FBN3 FGB FLAD1 FST FZR1 GAPDH GDF9 GDI1 GET3 GLB1 GPCPD1 HADHB HERC3 HMGXB3 HSPBAP1 IER3IP1 IGHM IMMT INPP5K INTS11 ITSN1 JADE1 JMJD1C KDM6B KIF21B KIF5A KLHL23 KLHL5 KMT2B LRIF1 MAGEA4 MAST2 MED31 METTL23 MKI67 MPP1 MPPED1 MRFAP1 MRPL20-AS1 MRPL37 MSH2 NEUROD2 NGFR NKIRAS2 NMT2 NRBP1 ODC1 PAAF1 PDE4DIP PJA1 PKM PLD3 PLXNA3 PPP4C PRMT1 PROC PSME1 PTPN4 PTPRK QARS1 RBBP4 RBM48 REX1BD RPA1 RPL13 RPS2 RUVBL1 RXRA SDF4 SEMA5B SEPTIN6 SETDB1 SEZ6L2 SMC5 SNX1 SP110 SULT1A3 SUMO2 SUMO3 TAF1C THOC3 TIAM2 TLE1 TMSB4X TP53 TRIM46 TRMT2A TSC2 TTC38 TUBA1A TUBB2A TUBB3 TYK2 UBC UNC119 UPF2 USP4 VMA22 WDR18 WDR73 WIZ ZBTB16 ZNF431 ZXDC	12 interacting genes: ANXA7 APP CDKN1A GADD45A GSK3B HGF PLAT PLG RPS6KA6 RPS6KB1 SH3GL2 TK1
Entrez ID		7083	7123
HPRD ID		01771	01759
Ensembl ID		ENSG00000167900	ENSG00000163815
Uniprot IDs		A0A384MDV9 K7ERV3 K7ES52 P04183	E9PHK0 P05452
PDB IDs		1W4R 1XBT 2ORV 2WVJ	1HTN 1RJH 1TN3 3L9J
Enriched GO Terms of Interacting Partners?		Cytoplasm Macromolecule Metabolic Process Protein Metabolic Process Platelet Alpha Granule Lumen Chromatin Organization Blood Microparticle Negative Regulation Of Cell Cycle G1/S Phase Transition Chromatin Remodeling Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Extracellular Exosome Cytosol Regulation Of DNA Replication Regulation Of G1/S Transition Of Mitotic Cell Cycle Protein Binding Nucleoplasm Positive Regulation Of Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Transferase Activity Nuclear Matrix Regulation Of Protein Catabolic Process DNA Synthesis Involved In Mitotic DNA Replication Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Macromolecule Biosynthetic Process Chromosome, Telomeric Region Positive Regulation Of Protein Metabolic Process Cytoskeleton Negative Regulation Of Cell Cycle Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Protein Tag Activity Developmental Process Growth Cone Protein Modification Process Cellular Response To Norepinephrine Stimulus Response To Norepinephrine Mitotic DNA Damage Checkpoint Signaling Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Oocyte Growth	Negative Regulation Of Multicellular Organismal Process Negative Regulation Of TORC2 Signaling Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Trans-synaptic Signaling By BDNF Negative Regulation Of Gene Expression Regulation Of Extrinsic Apoptotic Signaling Pathway Platelet Alpha Granule Lumen Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Reactive Oxygen Species Metabolic Process Modulation Of Chemical Synaptic Transmission Negative Regulation Of Metabolic Process Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle TOR Signaling Negative Regulation Of Fibrinolysis Trans-synaptic Signaling, Modulating Synaptic Transmission Glutamatergic Synapse Cellular Response To Growth Factor Stimulus Regulation Of TORC2 Signaling Regulation Of Multicellular Organismal Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway TORC2 Signaling Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Biosynthetic Process Apolipoprotein Binding Response To Growth Factor Regulation Of Fibrinolysis Regulation Of MAPK Cascade Fibrinolysis Negative Regulation Of Macromolecule Metabolic Process Developmental Growth Signaling Receptor Binding Central Nervous System Development Regulation Of Reactive Oxygen Species Metabolic Process Molecular Function Activator Activity Protein Serine/threonine Kinase Binding Regulation Of Apoptotic Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Mitotic Cell Cycle Phase Transition Signal Transduction In Response To DNA Damage Serine-type Endopeptidase Activity Positive Regulation Of Blood Coagulation Negative Regulation Of Catalytic Activity Cell Cycle Phase Transition Positive Regulation Of Coagulation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Intracellular Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
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