RAP1A and PDE6D

Number of citations of the paper that reports this interaction (PMID 11980706)
39

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (in vivo, two hybrid)

		RAP1A	PDE6D
Gene Name		RAP1A, member of RAS oncogene family	phosphodiesterase 6D, cGMP-specific, rod, delta
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Early Endosome Late Endosome Cytosol Plasma Membrane Cell Junction Guanyl-nucleotide Exchange Factor Complex Neuron Projection Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Cytosol Cytoskeleton Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Primary Cilium
	Molecular Function	GTPase Activity Protein Binding GTP Binding Protein Transporter Activity Ras GTPase Binding Rap Guanyl-nucleotide Exchange Factor Activity Protein Complex Binding	3',5'-cyclic-nucleotide Phosphodiesterase Activity GTPase Inhibitor Activity Protein Binding Rab GTPase Binding
	Biological Process	Activation Of MAPKK Activity Energy Reserve Metabolic Process Signal Transduction Blood Coagulation Positive Regulation Of Neuron Projection Development Protein Transport Microvillus Assembly Platelet Activation Rap Protein Signal Transduction Positive Regulation Of Rap GTPase Activity Nerve Growth Factor Signaling Pathway Small Molecule Metabolic Process Positive Regulation Of Protein Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Insulin Secretion Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Regulation Of Cell Junction Assembly Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Vasculogenesis	Organelle Organization Visual Perception Metabolic Process Negative Regulation Of Catalytic Activity Response To Stimulus
Pathways		Signalling to ERKs Signalling by NGF Prolonged ERK activation events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Integration of energy metabolism Regulation of insulin secretion p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling NGF signalling via TRKA from the plasma membrane GRB2:SOS provides linkage to MAPK signaling for Integrins Platelet Aggregation (Plug Formation) ARMS-mediated activation Rap1 signalling Platelet activation, signaling and aggregation Frs2-mediated activation Adaptive Immune System	Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance ARL13B-mediated ciliary trafficking of INPP5E Assembly of the primary cilium
Drugs
Diseases
GWAS		Osteoporosis ( 20548944)	Eating disorders (purging via substances) ( 23568457) Height ( 18391951)
Protein-Protein Interactions		41 interactors: APBB1IP ARHGEF1 BIN1 BMX BRAF FADD FAF1 FAS GABARAPL2 GANAB HDAC1 HSPA1A KRIT1 MLLT4 MTNR1A NTRK1 PDE6D PPP2R1A PRKACA RABAC1 RAF1 RALA RALGDS RAP1GAP RAP1GDS1 RAPGEF2 RAPGEF3 RAPGEF4 RAPGEF5 RAPGEF6 RASA1 RASA3 RASGRP2 RASGRP4 RASIP1 RGL4 RGS14 RUNDC3A SMARCA4 TCEB3 TNFRSF10C	24 interactors: ARL15 ARL16 ARL2 ARL3 CDC42 CETN3 FAM219A GNAI1 GRK1 GRK7 HRAS PTGIR RAB13 RAB18 RAB8A RAD23A RAP1A RAP2B RASA1 RHEB RHOA RHOB RND1 RPGR
Entrez ID		5906	5147
HPRD ID		01545	04056
Ensembl ID		ENSG00000116473	ENSG00000156973
Uniprot IDs		A8KAH9 P62834	O43924 Q6IB24
PDB IDs		1C1Y 1GUA 3KUC	1KSG 1KSH 1KSJ 3T5G 3T5I 4JHP 4JV6 4JV8 4JVB 4JVF
Enriched GO Terms of Interacting Partners?		Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Hydrolase Activity Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Rap GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Small GTPase Mediated Signal Transduction Regulation Of Signaling Regulation Of Ras Protein Signal Transduction Regulation Of Ras GTPase Activity Regulation Of Rap GTPase Activity Positive Regulation Of Ras GTPase Activity Intracellular Signal Transduction Regulation Of Rap Protein Signal Transduction Signal Transduction Cell Communication Regulation Of Metabolic Process Cellular Response To Stimulus Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Stimulus Ras Protein Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Cellular Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Cyclic Nucleotide Metabolic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Apoptotic Process Regulation Of Cell Death Cell Activation Regulation Of Protein Kinase Activity Negative Regulation Of Signaling Regulation Of Kinase Activity Cell Surface Receptor Signaling Pathway Platelet Activation Regulation Of Cell Differentiation Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Lyase Activity Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cell Differentiation	Small GTPase Mediated Signal Transduction Intracellular Signal Transduction Ras Protein Signal Transduction Signal Transduction Signaling Cellular Response To Stimulus Neuron Development Cell Communication Response To Stimulus Neuron Differentiation Blood Coagulation Hemostasis Generation Of Neurons Neurogenesis Cell Morphogenesis Cell Development Nervous System Development Regulation Of Body Fluid Levels Cell Projection Organization Cell Projection Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Cell Part Morphogenesis Wound Healing Response To Wounding Cell Cycle Cell Morphogenesis Involved In Differentiation Axonogenesis Neuron Projection Development Axon Development Platelet Activation Chemotaxis Axon Guidance Neuron Projection Morphogenesis Ephrin Receptor Signaling Pathway Cell Division Vascular Endothelial Growth Factor Receptor Signaling Pathway Cytokinesis Cell Cycle Process Protein Localization Movement Of Cell Or Subcellular Component Organelle Organization Photoreceptor Cell Development Cell Differentiation Cellular Protein Localization Response To External Stimulus Rab Protein Signal Transduction System Development Protein Transport Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Process
Tagcloud ?		bfa bisphosphonates brefeldin camp cathepsin cdc42 cytoskeletal diminish diminished epac epac1 epac2 esi fak intermediates isoprenylation ko multinucleated nfatc1 nfkb osteoclast osteopontin pctp permit rac1 rankl raw264 rhoa	14e4 1c4 3h1 4d2 bands bmpr1b copy e5 hybridisation losses ontology pdlim5 ptc ptcs ptma slitrk1 slitrk5 slitrk6 srm t1 taf12 tp73 transgenics trk trp73 tumourigenesis twist2 unc5c ythdf2
Tagcloud (Difference) ?		bfa bisphosphonates brefeldin camp cathepsin cdc42 cytoskeletal diminish diminished epac epac1 epac2 esi fak intermediates isoprenylation ko multinucleated nfatc1 nfkb osteoclast osteopontin pctp permit rac1 rankl raw264 rhoa	14e4 1c4 3h1 4d2 bands bmpr1b copy e5 hybridisation losses ontology pdlim5 ptc ptcs ptma slitrk1 slitrk5 slitrk6 srm t1 taf12 tp73 transgenics trk trp73 tumourigenesis twist2 unc5c ythdf2
Tagcloud (Intersection) ?