RAP1A and PDE6D

Number of citations of the paper that reports this interaction (PubMedID 11980706)
67

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (two hybrid, in vivo)

		RAP1A	PDE6D
Description		RAP1A, member of RAS oncogene family	phosphodiesterase 6D
Image
GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Late Endosome Cytosol Plasma Membrane Endosome Membrane Membrane Cell Junction Guanyl-nucleotide Exchange Factor Complex Specific Granule Membrane Neuron Projection Phagocytic Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome Anchoring Junction Sperm Midpiece Presynapse Glutamatergic Synapse	Cytoplasm Cytosol Cytoskeleton Cilium Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Cell Projection
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Small GTPase Binding Protein-containing Complex Binding	GTPase Inhibitor Activity Protein Binding Small GTPase Binding
	Biological Process	Signal Transduction Small GTPase-mediated Signal Transduction Nervous System Development Response To Carbohydrate Positive Regulation Of Neuron Projection Development Synaptic Vesicle Exocytosis Rap Protein Signal Transduction Negative Regulation Of Collagen Biosynthetic Process Nerve Growth Factor Signaling Pathway Positive Regulation Of GTPase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of D-glucose Import Positive Regulation Of Phagocytosis Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Protein Localization To Plasma Membrane Response To Antineoplastic Agent Liver Regeneration Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Cell Junction Assembly Cellular Response To Forskolin Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Vasculogenesis	Visual Perception Sensory Perception Of Light Stimulus
Pathways		Frs2-mediated activation Frs2-mediated activation ARMS-mediated activation ARMS-mediated activation Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling MAP2K and MAPK activation Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF MET activates RAP1 and RAC1 Signaling downstream of RAS mutants Signaling by RAF1 mutants	ARL13B-mediated ciliary trafficking of INPP5E RAS processing
Drugs
Diseases
GWAS		Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Crohn's disease ( 30500874 32581322) High altitude adaptation ( 28373541) Lymphocyte count ( 32888494) Osteoporosis-related phenotypes ( 20548944)	Eating disorders (purging via substances) ( 23568457) Height ( 18391951)
Interacting Genes		43 interacting genes: AFDN APBB1IP ARHGEF1 BIN1 BMX BRAF ELOA FADD FAF1 FAS GABARAPL2 GANAB HDAC1 HSPA1A HSPA4 KRIT1 MTNR1A NTRK1 PDE6D PPP2R1A PRKACA RABAC1 RAF1 RALGDS RAP1GAP RAP1GDS1 RAPGEF1 RAPGEF2 RAPGEF3 RAPGEF4 RAPGEF5 RAPGEF6 RASA1 RASA3 RASGRP2 RASGRP4 RASIP1 RGL4 RGS14 RUNDC3A SMARCA2 SMARCA4 TNFRSF10C	25 interacting genes: ARL15 ARL16 ARL2 ARL3 CDC42 CETN3 FAM219A GNAI1 GRK1 GRK7 HRAS OTP PTGIR RAB13 RAB18 RAB8A RAD23A RAP1A RAP2B RASA1 RHEB RHOA RHOB RND1 RPGR
Entrez ID		5906	5147
HPRD ID		01545	04056
Ensembl ID		ENSG00000116473	ENSG00000156973
Uniprot IDs		A8KAH9 P62834	B8ZZK5 O43924 Q6IB24
PDB IDs		1C1Y 1GUA 3KUC 4KVG	1KSG 1KSH 1KSJ 3T5G 3T5I 4JHP 4JV6 4JV8 4JVB 4JVF 5E80 5E8F 5F2U 5ML2 5ML3 5ML4 5ML6 5ML8 5NAL 5TAR 5TB5 5X72 5X73 5X74 5YAV 5YAW 7PAC 7PAD 7PAE 7Q9Q 7Q9R 7Q9S 7Q9U 7QF9 7QJK
Enriched GO Terms of Interacting Partners?		GTPase Regulator Activity Ras Protein Signal Transduction Small GTPase-mediated Signal Transduction Guanyl-nucleotide Exchange Factor Activity Signal Transduction Intracellular Signaling Cassette Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of GTPase Activity Plasma Membrane Establishment Of Endothelial Barrier Endothelial Cell Development Positive Regulation Of GTPase Activity CD95 Death-inducing Signaling Complex Positive Regulation Of Hydrolase Activity Neurotrophin Signaling Pathway Epithelial Cell Development Rap Protein Signal Transduction Regulation Of Microvillus Assembly GTPase Binding Regulation Of Signal Transduction Regulation Of Apoptotic Process Cytosol Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Cell Communication Regulation Of Signaling Small GTPase Binding Nerve Growth Factor Signaling Pathway Establishment Of Endothelial Intestinal Barrier Death-inducing Signaling Complex Assembly Diacylglycerol Binding Regulation Of Programmed Cell Death Regulation Of Catalytic Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling CAMP Binding Fas Signaling Pathway Protein-containing Complex Organization Cytoplasm Positive Regulation Of Cellular Component Biogenesis Regulation Of Developmental Process Protein-containing Complex Assembly GTPase Activator Activity Regulation Of Cellular Component Organization Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Programmed Cell Death Nucleosome Array Spacer Activity Positive Regulation Of Microvillus Assembly Regulation Of Cell Differentiation	GTPase Activity GTP Binding GDP Binding Nucleotide Binding Small GTPase-mediated Signal Transduction G Protein Activity Intracellular Signaling Cassette Ciliary Basal Body Intracellular Signal Transduction Mitotic Cytokinesis Midbody Rhodopsin Kinase Activity Regulation Of Cytoskeleton Organization Cytoskeleton-dependent Cytokinesis Centrosome Photoreceptor Connecting Cilium Hydrolase Activity Signal Transduction G Protein-coupled Receptor Kinase Activity Cellular Developmental Process Golgi Apparatus Extracellular Exosome Rap Protein Signal Transduction Regulation Of Opsin-mediated Signaling Pathway Protein Localization To Cilium Cell-cell Junction Organization Cytoskeleton Regulation Of Actin Cytoskeleton Organization Endothelial Tube Morphogenesis Regulation Of Actin Filament-based Process Regulation Of Modification Of Postsynaptic Structure Cellular Response To Forskolin Phagocytic Vesicle Regulation Of Cell-substrate Adhesion Establishment Of Epithelial Cell Apical/basal Polarity Response To Forskolin Trans-Golgi Network Transport Vesicle Protein Localization To Cell Periphery Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Modification Of Synaptic Structure Recycling Endosome Membrane Photoreceptor Disc Membrane Protein Kinase Binding Establishment Of Apical/basal Cell Polarity G-protein Beta/gamma-subunit Complex Binding Polarized Epithelial Cell Differentiation Establishment Of Monopolar Cell Polarity Actin Filament Organization Cell Junction Assembly Establishment Or Maintenance Of Monopolar Cell Polarity
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