RAP1A and TNFRSF10C

Number of citations of the paper that reports this interaction (PMID 15207703)
1

Data Source:
HPRD (in vivo)

		RAP1A	TNFRSF10C
Gene Name		RAP1A, member of RAS oncogene family	tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Early Endosome Late Endosome Cytosol Plasma Membrane Cell Junction Guanyl-nucleotide Exchange Factor Complex Neuron Projection Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Integral Component Of Plasma Membrane Anchored Component Of Membrane
	Molecular Function	GTPase Activity Protein Binding GTP Binding Protein Transporter Activity Ras GTPase Binding Rap Guanyl-nucleotide Exchange Factor Activity Protein Complex Binding	Transmembrane Signaling Receptor Activity TRAIL Binding
	Biological Process	Activation Of MAPKK Activity Energy Reserve Metabolic Process Signal Transduction Blood Coagulation Positive Regulation Of Neuron Projection Development Protein Transport Microvillus Assembly Platelet Activation Rap Protein Signal Transduction Positive Regulation Of Rap GTPase Activity Nerve Growth Factor Signaling Pathway Small Molecule Metabolic Process Positive Regulation Of Protein Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Insulin Secretion Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Regulation Of Cell Junction Assembly Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Vasculogenesis	Apoptotic Process Signal Transduction
Pathways		Signalling to ERKs Signalling by NGF Prolonged ERK activation events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Integration of energy metabolism Regulation of insulin secretion p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling NGF signalling via TRKA from the plasma membrane GRB2:SOS provides linkage to MAPK signaling for Integrins Platelet Aggregation (Plug Formation) ARMS-mediated activation Rap1 signalling Platelet activation, signaling and aggregation Frs2-mediated activation Adaptive Immune System
Drugs
Diseases
GWAS		Osteoporosis ( 20548944)
Protein-Protein Interactions		41 interactors: APBB1IP ARHGEF1 BIN1 BMX BRAF FADD FAF1 FAS GABARAPL2 GANAB HDAC1 HSPA1A KRIT1 MLLT4 MTNR1A NTRK1 PDE6D PPP2R1A PRKACA RABAC1 RAF1 RALA RALGDS RAP1GAP RAP1GDS1 RAPGEF2 RAPGEF3 RAPGEF4 RAPGEF5 RAPGEF6 RASA1 RASA3 RASGRP2 RASGRP4 RASIP1 RGL4 RGS14 RUNDC3A SMARCA4 TCEB3 TNFRSF10C	9 interactors: APOA1 FAM101B LRSAM1 RAP1A SLC27A6 SRPK1 SRPK2 TNFSF10 ZHX1
Entrez ID		5906	8794
HPRD ID		01545	04681
Ensembl ID		ENSG00000116473	ENSG00000173535
Uniprot IDs		A8KAH9 P62834	O14798
PDB IDs		1C1Y 1GUA 3KUC
Enriched GO Terms of Interacting Partners?		Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Hydrolase Activity Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Rap GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Small GTPase Mediated Signal Transduction Regulation Of Signaling Regulation Of Ras Protein Signal Transduction Regulation Of Ras GTPase Activity Regulation Of Rap GTPase Activity Positive Regulation Of Ras GTPase Activity Intracellular Signal Transduction Regulation Of Rap Protein Signal Transduction Signal Transduction Cell Communication Regulation Of Metabolic Process Cellular Response To Stimulus Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Stimulus Ras Protein Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Cellular Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Cyclic Nucleotide Metabolic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Apoptotic Process Regulation Of Cell Death Cell Activation Regulation Of Protein Kinase Activity Negative Regulation Of Signaling Regulation Of Kinase Activity Cell Surface Receptor Signaling Pathway Platelet Activation Regulation Of Cell Differentiation Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Lyase Activity Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cell Differentiation	Positive Regulation Of Viral Genome Replication Negative Regulation Of Viral Genome Replication Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Viral Genome Replication Positive Regulation Of Viral Process Negative Regulation Of Transport Negative Regulation Of Viral Process Negative Regulation Of Cell Adhesion Molecule Production Nuclear Speck Organization Ubiquitin-dependent Endocytosis Regulation Of MRNA Processing Cell Differentiation Regulation Of RNA Splicing Negative Regulation Of Interleukin-1 Beta Secretion Developmental Process Nucleus Organization Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Cholesterol Import Negative Regulation Of Interleukin-1 Secretion Regulation Of Viral Process Negative Regulation Of Secretion By Cell Negative Regulation Of Secretion High-density Lipoprotein Particle Clearance Platelet Activation Protein Oxidation Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of Cytokine Secretion Involved In Immune Response High-density Lipoprotein Particle Assembly Cell Development Positive Regulation Of Triglyceride Catabolic Process Positive Regulation Of Cholesterol Esterification Sperm Chromatin Condensation Viral Budding Regulation Of Intestinal Cholesterol Absorption Rap Protein Signal Transduction Phospholipid Homeostasis Peptidyl-methionine Modification Anatomical Structure Development Regulation Of Cellular Component Organization Regulation Of Cholesterol Esterification Peripheral Nervous System Axon Regeneration Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Vasculogenesis Phospholipid Efflux Nerve Growth Factor Signaling Pathway Regulation Of Cytokine Secretion Involved In Immune Response Lipid Transport Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Lipoprotein Lipase Activity
Tagcloud ?		bfa bisphosphonates brefeldin camp cathepsin cdc42 cytoskeletal diminish diminished epac epac1 epac2 esi fak intermediates isoprenylation ko multinucleated nfatc1 nfkb osteoclast osteopontin pctp permit rac1 rankl raw264 rhoa
Tagcloud (Difference) ?		bfa bisphosphonates brefeldin camp cathepsin cdc42 cytoskeletal diminish diminished epac epac1 epac2 esi fak intermediates isoprenylation ko multinucleated nfatc1 nfkb osteoclast osteopontin pctp permit rac1 rankl raw264 rhoa
Tagcloud (Intersection) ?