RAP1A and ARHGEF1

Number of citations of the paper that reports this interaction (PMID 12581858)
13

Data Source:
BioGRID (enzymatic study)

		RAP1A	ARHGEF1
Gene Name		RAP1A, member of RAS oncogene family	Rho guanine nucleotide exchange factor (GEF) 1
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Gene Ontology Annotations	Cellular Component	Cytoplasm Early Endosome Late Endosome Cytosol Plasma Membrane Cell Junction Guanyl-nucleotide Exchange Factor Complex Neuron Projection Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Cytoplasm Cytosol Plasma Membrane
	Molecular Function	GTPase Activity Protein Binding GTP Binding Protein Transporter Activity Ras GTPase Binding Rap Guanyl-nucleotide Exchange Factor Activity Protein Complex Binding	Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Poly(A) RNA Binding
	Biological Process	Activation Of MAPKK Activity Energy Reserve Metabolic Process Signal Transduction Blood Coagulation Positive Regulation Of Neuron Projection Development Protein Transport Microvillus Assembly Platelet Activation Rap Protein Signal Transduction Positive Regulation Of Rap GTPase Activity Nerve Growth Factor Signaling Pathway Small Molecule Metabolic Process Positive Regulation Of Protein Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Insulin Secretion Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Regulation Of Cell Junction Assembly Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Vasculogenesis	Rho Protein Signal Transduction Cell Proliferation Positive Regulation Of Rho GTPase Activity Termination Of G-protein Coupled Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Regulation Of Axonogenesis Negative Regulation Of Axonogenesis
Pathways		Signalling to ERKs Signalling by NGF Prolonged ERK activation events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Integration of energy metabolism Regulation of insulin secretion p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling NGF signalling via TRKA from the plasma membrane GRB2:SOS provides linkage to MAPK signaling for Integrins Platelet Aggregation (Plug Formation) ARMS-mediated activation Rap1 signalling Platelet activation, signaling and aggregation Frs2-mediated activation Adaptive Immune System	Signaling by GPCR GPCR downstream signaling Signalling by NGF Axonal growth inhibition (RHOA activation) p75NTR regulates axonogenesis G alpha (12/13) signalling events p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS		Osteoporosis ( 20548944)
Protein-Protein Interactions		41 interactors: APBB1IP ARHGEF1 BIN1 BMX BRAF FADD FAF1 FAS GABARAPL2 GANAB HDAC1 HSPA1A KRIT1 MLLT4 MTNR1A NTRK1 PDE6D PPP2R1A PRKACA RABAC1 RAF1 RALA RALGDS RAP1GAP RAP1GDS1 RAPGEF2 RAPGEF3 RAPGEF4 RAPGEF5 RAPGEF6 RASA1 RASA3 RASGRP2 RASGRP4 RASIP1 RGL4 RGS14 RUNDC3A SMARCA4 TCEB3 TNFRSF10C	11 interactors: ATR CD44 CNKSR1 CSNK1E GNA13 HRAS PRKCA RAP1A RHOA SREBF2 TCF4
Entrez ID		5906	9138
HPRD ID		01545	03511
Ensembl ID		ENSG00000116473	ENSG00000076928
Uniprot IDs		A8KAH9 P62834	Q6NX52 Q92888
PDB IDs		1C1Y 1GUA 3KUC	1IAP 1SHZ 3AB3 3ODO 3ODW 3ODX 3P6A
Enriched GO Terms of Interacting Partners?		Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Hydrolase Activity Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Rap GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Small GTPase Mediated Signal Transduction Regulation Of Signaling Regulation Of Ras Protein Signal Transduction Regulation Of Ras GTPase Activity Regulation Of Rap GTPase Activity Positive Regulation Of Ras GTPase Activity Intracellular Signal Transduction Regulation Of Rap Protein Signal Transduction Signal Transduction Cell Communication Regulation Of Metabolic Process Cellular Response To Stimulus Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Stimulus Ras Protein Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Cellular Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Cyclic Nucleotide Metabolic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Apoptotic Process Regulation Of Cell Death Cell Activation Regulation Of Protein Kinase Activity Negative Regulation Of Signaling Regulation Of Kinase Activity Cell Surface Receptor Signaling Pathway Platelet Activation Regulation Of Cell Differentiation Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Lyase Activity Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cell Differentiation	Positive Regulation Of Signal Transduction Blood Coagulation Hemostasis Positive Regulation Of Intracellular Signal Transduction Ras Protein Signal Transduction Response To Stress Regulation Of Body Fluid Levels Wound Healing Positive Regulation Of ERK1 And ERK2 Cascade Response To Wounding Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of ERK1 And ERK2 Cascade Platelet Activation Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Rho Protein Signal Transduction Signal Transduction Cell Cycle Process Tissue Development Regulation Of Intracellular Signal Transduction Epithelium Development Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Signal Transduction Small GTPase Mediated Signal Transduction Signaling Cell Communication Positive Regulation Of Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Stimulus Regulation Of Signaling Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Cycle Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Peptidyl-serine Phosphorylation Anatomical Structure Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Energy Reserve Metabolic Process Tube Morphogenesis Response To Organic Substance Positive Regulation Of MAPK Cascade Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Epithelial Cell Proliferation Regulation Of Cell Morphogenesis Morphogenesis Of An Epithelium Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Intracellular Signal Transduction Cellular Response To Fibroblast Growth Factor Stimulus
Tagcloud ?		bfa bisphosphonates brefeldin camp cathepsin cdc42 cytoskeletal diminish diminished epac epac1 epac2 esi fak intermediates isoprenylation ko multinucleated nfatc1 nfkb osteoclast osteopontin pctp permit rac1 rankl raw264 rhoa	activates angiotensin arterial arteries causative elusive environmental exchange feature frequent guanine hypertension ii inactivation industrialized monomeric muscle pathologies phosphorylates recognized remains responsible rhoa smooth specifically tyr738 unclear undescribed world
Tagcloud (Difference) ?		bfa bisphosphonates brefeldin camp cathepsin cdc42 cytoskeletal diminish diminished epac epac1 epac2 esi fak intermediates isoprenylation ko multinucleated nfatc1 nfkb osteoclast osteopontin pctp permit rac1 rankl raw264	activates angiotensin arterial arteries causative elusive environmental exchange feature frequent guanine hypertension ii inactivation industrialized monomeric muscle pathologies phosphorylates recognized remains responsible smooth specifically tyr738 unclear undescribed world
Tagcloud (Intersection) ?		rhoa