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RAP1A and APBB1IP
Number of citations of the paper that reports this interaction (PMID
15469846
)
97
Data Source:
HPRD
(in vivo, in vitro, two hybrid)
RAP1A
APBB1IP
Gene Name
RAP1A, member of RAS oncogene family
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
Image
Gene Ontology Annotations
Cellular Component
Cytoplasm
Early Endosome
Late Endosome
Cytosol
Plasma Membrane
Cell Junction
Guanyl-nucleotide Exchange Factor Complex
Neuron Projection
Perinuclear Region Of Cytoplasm
Extracellular Vesicular Exosome
Cytosol
Cytoskeleton
Plasma Membrane
Focal Adhesion
Lamellipodium
Molecular Function
GTPase Activity
Protein Binding
GTP Binding
Protein Transporter Activity
Ras GTPase Binding
Rap Guanyl-nucleotide Exchange Factor Activity
Protein Complex Binding
Protein Binding
Biological Process
Activation Of MAPKK Activity
Energy Reserve Metabolic Process
Signal Transduction
Blood Coagulation
Positive Regulation Of Neuron Projection Development
Protein Transport
Microvillus Assembly
Platelet Activation
Rap Protein Signal Transduction
Positive Regulation Of Rap GTPase Activity
Nerve Growth Factor Signaling Pathway
Small Molecule Metabolic Process
Positive Regulation Of Protein Kinase Activity
Neurotrophin TRK Receptor Signaling Pathway
Regulation Of Insulin Secretion
Establishment Of Endothelial Barrier
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To CAMP
Regulation Of Cell Junction Assembly
Cellular Response To Nerve Growth Factor Stimulus
Negative Regulation Of Synaptic Vesicle Exocytosis
Positive Regulation Of Vasculogenesis
Signal Transduction
Blood Coagulation
Platelet Activation
Pathways
Signalling to ERKs
Signalling by NGF
Prolonged ERK activation events
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Integration of energy metabolism
Regulation of insulin secretion
p130Cas linkage to MAPK signaling for integrins
Integrin alphaIIb beta3 signaling
NGF signalling via TRKA from the plasma membrane
GRB2:SOS provides linkage to MAPK signaling for Integrins
Platelet Aggregation (Plug Formation)
ARMS-mediated activation
Rap1 signalling
Platelet activation, signaling and aggregation
Frs2-mediated activation
Adaptive Immune System
p130Cas linkage to MAPK signaling for integrins
Integrin alphaIIb beta3 signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
Platelet activation, signaling and aggregation
Platelet Aggregation (Plug Formation)
Drugs
Diseases
GWAS
Osteoporosis (
20548944
)
Inflammatory biomarkers (
22228203
)
Response to angiotensin II receptor blocker therapy (
22566498
)
Protein-Protein Interactions
41 interactors:
APBB1IP
ARHGEF1
BIN1
BMX
BRAF
FADD
FAF1
FAS
GABARAPL2
GANAB
HDAC1
HSPA1A
KRIT1
MLLT4
MTNR1A
NTRK1
PDE6D
PPP2R1A
PRKACA
RABAC1
RAF1
RALA
RALGDS
RAP1GAP
RAP1GDS1
RAPGEF2
RAPGEF3
RAPGEF4
RAPGEF5
RAPGEF6
RASA1
RASA3
RASGRP2
RASGRP4
RASIP1
RGL4
RGS14
RUNDC3A
SMARCA4
TCEB3
TNFRSF10C
8 interactors:
EVL
GAS7
NDN
PFN1
PRPF40A
RAP1A
VASP
ZDHHC17
Entrez ID
5906
54518
HPRD ID
01545
16420
Ensembl ID
ENSG00000116473
ENSG00000077420
Uniprot IDs
A8KAH9
P62834
B4E100
Q7Z5R6
PDB IDs
1C1Y
1GUA
3KUC
3ZDL
Enriched GO Terms of Interacting Partners
?
Regulation Of Catalytic Activity
Positive Regulation Of Catalytic Activity
Positive Regulation Of Hydrolase Activity
Regulation Of GTPase Activity
Positive Regulation Of GTPase Activity
Positive Regulation Of Metabolic Process
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Rap GTPase Activity
Regulation Of Small GTPase Mediated Signal Transduction
Small GTPase Mediated Signal Transduction
Regulation Of Signaling
Regulation Of Ras Protein Signal Transduction
Regulation Of Ras GTPase Activity
Regulation Of Rap GTPase Activity
Positive Regulation Of Ras GTPase Activity
Intracellular Signal Transduction
Regulation Of Rap Protein Signal Transduction
Signal Transduction
Cell Communication
Regulation Of Metabolic Process
Cellular Response To Stimulus
Signaling
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Response To Stimulus
Ras Protein Signal Transduction
Enzyme Linked Receptor Protein Signaling Pathway
Neurotrophin Signaling Pathway
Regulation Of Cellular Process
Neurotrophin TRK Receptor Signaling Pathway
Regulation Of Cellular Component Organization
Positive Regulation Of Cyclic Nucleotide Metabolic Process
Cellular Response To Growth Factor Stimulus
Response To Growth Factor
Regulation Of Apoptotic Process
Regulation Of Cell Death
Cell Activation
Regulation Of Protein Kinase Activity
Negative Regulation Of Signaling
Regulation Of Kinase Activity
Cell Surface Receptor Signaling Pathway
Platelet Activation
Regulation Of Cell Differentiation
Regulation Of Extrinsic Apoptotic Signaling Pathway
Negative Regulation Of Signal Transduction
Positive Regulation Of Lyase Activity
Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Cell Differentiation
Actin Polymerization Or Depolymerization
Positive Regulation Of Actin Filament Polymerization
Positive Regulation Of Protein Polymerization
Regulation Of Cellular Component Organization
Cytoskeleton Organization
Regulation Of Ruffle Assembly
Nervous System Development
Positive Regulation Of Protein Complex Assembly
Regulation Of Actin Filament Polymerization
Actin Cytoskeleton Organization
Regulation Of Actin Polymerization Or Depolymerization
Regulation Of Actin Filament Length
Positive Regulation Of Cytoskeleton Organization
Neuron Projection Morphogenesis
Actin Filament-based Process
Generation Of Neurons
Neurogenesis
Neuron Projection Development
Cell Projection Morphogenesis
Positive Regulation Of Stress Fiber Assembly
Actin Filament Organization
Cell Part Morphogenesis
Positive Regulation Of Actin Filament Bundle Assembly
Positive Regulation Of Cellular Component Biogenesis
Cell Development
Regulation Of Cellular Component Size
Regulation Of Protein Complex Assembly
Neuron Development
Regulation Of Actin Cytoskeleton Organization
Regulation Of Stress Fiber Assembly
Protein Homotetramerization
Cell Morphogenesis
Positive Regulation Of Organelle Organization
Regulation Of Actin Filament-based Process
Neuron Differentiation
Cell Projection Organization
Regulation Of Cell Projection Organization
Locomotion
Anatomical Structure Morphogenesis
Regulation Of Cytoskeleton Organization
Protein Tetramerization
Neural Tube Closure
Axonogenesis
System Development
Regulation Of Cell Projection Assembly
Axon Development
Cellular Response To Growth Factor Stimulus
Cell Morphogenesis Involved In Neuron Differentiation
Neural Tube Formation
Response To Growth Factor
Tagcloud
?
bfa
bisphosphonates
brefeldin
camp
cathepsin
cdc42
cytoskeletal
diminish
diminished
epac
epac1
epac2
esi
fak
intermediates
isoprenylation
ko
multinucleated
nfatc1
nfkb
osteoclast
osteopontin
pctp
permit
rac1
rankl
raw264
rhoa
Tagcloud (Difference)
?
bfa
bisphosphonates
brefeldin
camp
cathepsin
cdc42
cytoskeletal
diminish
diminished
epac
epac1
epac2
esi
fak
intermediates
isoprenylation
ko
multinucleated
nfatc1
nfkb
osteoclast
osteopontin
pctp
permit
rac1
rankl
raw264
rhoa
Tagcloud (Intersection)
?