RAP1A and RGL4

Number of citations of the paper that reports this interaction (PMID 12874025)
7

Data Source:
HPRD (in vitro)

		RAP1A	RGL4
Gene Name		RAP1A, member of RAS oncogene family	ral guanine nucleotide dissociation stimulator-like 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Early Endosome Late Endosome Cytosol Plasma Membrane Cell Junction Guanyl-nucleotide Exchange Factor Complex Neuron Projection Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Cytoplasmic Membrane-bounded Vesicle
	Molecular Function	GTPase Activity Protein Binding GTP Binding Protein Transporter Activity Ras GTPase Binding Rap Guanyl-nucleotide Exchange Factor Activity Protein Complex Binding	Guanyl-nucleotide Exchange Factor Activity
	Biological Process	Activation Of MAPKK Activity Energy Reserve Metabolic Process Signal Transduction Blood Coagulation Positive Regulation Of Neuron Projection Development Protein Transport Microvillus Assembly Platelet Activation Rap Protein Signal Transduction Positive Regulation Of Rap GTPase Activity Nerve Growth Factor Signaling Pathway Small Molecule Metabolic Process Positive Regulation Of Protein Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Insulin Secretion Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Regulation Of Cell Junction Assembly Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Vasculogenesis	Small GTPase Mediated Signal Transduction Positive Regulation Of GTPase Activity
Pathways		Signalling to ERKs Signalling by NGF Prolonged ERK activation events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Integration of energy metabolism Regulation of insulin secretion p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling NGF signalling via TRKA from the plasma membrane GRB2:SOS provides linkage to MAPK signaling for Integrins Platelet Aggregation (Plug Formation) ARMS-mediated activation Rap1 signalling Platelet activation, signaling and aggregation Frs2-mediated activation Adaptive Immune System
Drugs
Diseases
GWAS		Osteoporosis ( 20548944)
Protein-Protein Interactions		41 interactors: APBB1IP ARHGEF1 BIN1 BMX BRAF FADD FAF1 FAS GABARAPL2 GANAB HDAC1 HSPA1A KRIT1 MLLT4 MTNR1A NTRK1 PDE6D PPP2R1A PRKACA RABAC1 RAF1 RALA RALGDS RAP1GAP RAP1GDS1 RAPGEF2 RAPGEF3 RAPGEF4 RAPGEF5 RAPGEF6 RASA1 RASA3 RASGRP2 RASGRP4 RASIP1 RGL4 RGS14 RUNDC3A SMARCA4 TCEB3 TNFRSF10C	4 interactors: HRAS RALA RALB RAP1A
Entrez ID		5906	266747
HPRD ID		01545	11528
Ensembl ID		ENSG00000116473	ENSG00000159496
Uniprot IDs		A8KAH9 P62834	Q8IZJ4
PDB IDs		1C1Y 1GUA 3KUC
Enriched GO Terms of Interacting Partners?		Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Hydrolase Activity Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Rap GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Small GTPase Mediated Signal Transduction Regulation Of Signaling Regulation Of Ras Protein Signal Transduction Regulation Of Ras GTPase Activity Regulation Of Rap GTPase Activity Positive Regulation Of Ras GTPase Activity Intracellular Signal Transduction Regulation Of Rap Protein Signal Transduction Signal Transduction Cell Communication Regulation Of Metabolic Process Cellular Response To Stimulus Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Stimulus Ras Protein Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Cellular Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Cyclic Nucleotide Metabolic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Apoptotic Process Regulation Of Cell Death Cell Activation Regulation Of Protein Kinase Activity Negative Regulation Of Signaling Regulation Of Kinase Activity Cell Surface Receptor Signaling Pathway Platelet Activation Regulation Of Cell Differentiation Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Lyase Activity Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cell Differentiation	Neurotrophin TRK Receptor Signaling Pathway Ras Protein Signal Transduction Neurotrophin Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Small GTPase Mediated Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Exocytosis Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Projection Organization Positive Regulation Of Cellular Component Biogenesis Regulation Of Vesicle-mediated Transport Positive Regulation Of Protein Kinase Activity Regulation Of Cell Projection Organization Positive Regulation Of Kinase Activity Intracellular Signal Transduction Cellular Response To Organic Substance Activation Of MAPKK Activity Regulation Of Cellular Component Organization Positive Regulation Of Transferase Activity Regulation Of Secretion Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Cytokinesis Response To Organic Substance Regulation Of Kinase Activity Regulation Of Cell Projection Assembly Regulation Of Exocyst Assembly Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Cell Surface Receptor Signaling Pathway Regulation Of Exocyst Localization Positive Regulation Of Autophagic Vacuole Assembly Positive Regulation Of Vacuole Organization Regulation Of Cellular Localization Cell Cycle Process Regulation Of Protein Phosphorylation Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Membrane Raft Localization Regulation Of Phosphorylation Cell Cycle Positive Regulation Of Rac Protein Signal Transduction Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of MiRNA Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Synaptic Transmission
Tagcloud ?		bfa bisphosphonates brefeldin camp cathepsin cdc42 cytoskeletal diminish diminished epac epac1 epac2 esi fak intermediates isoprenylation ko multinucleated nfatc1 nfkb osteoclast osteopontin pctp permit rac1 rankl raw264 rhoa
Tagcloud (Difference) ?		bfa bisphosphonates brefeldin camp cathepsin cdc42 cytoskeletal diminish diminished epac epac1 epac2 esi fak intermediates isoprenylation ko multinucleated nfatc1 nfkb osteoclast osteopontin pctp permit rac1 rankl raw264 rhoa
Tagcloud (Intersection) ?