RAP1A and KRIT1

Number of citations: 0 (PubMedID 9285558)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		RAP1A	KRIT1
Name		RAP1A, member of RAS oncogene family	KRIT1 ankyrin repeat containing
Structure
GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Late Endosome Cytosol Plasma Membrane Endosome Membrane Membrane Cell Junction Guanyl-nucleotide Exchange Factor Complex Specific Granule Membrane Neuron Projection Phagocytic Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome Anchoring Junction Sperm Midpiece Presynapse Glutamatergic Synapse	Extracellular Space Cytoplasm Cytoskeleton Plasma Membrane Cell-cell Junction Membrane Protein-containing Complex Anchoring Junction
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Small GTPase Binding Protein-containing Complex Binding	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Microtubule Binding GTPase Regulator Activity
	Biological Process	Signal Transduction Small GTPase-mediated Signal Transduction Nervous System Development Response To Carbohydrate Positive Regulation Of Neuron Projection Development Synaptic Vesicle Exocytosis Rap Protein Signal Transduction Negative Regulation Of Collagen Biosynthetic Process Nerve Growth Factor Signaling Pathway Positive Regulation Of GTPase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of D-glucose Import Positive Regulation Of Phagocytosis Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Protein Localization To Plasma Membrane Response To Antineoplastic Agent Liver Regeneration Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Cell Junction Assembly Cellular Response To Forskolin Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Vasculogenesis	Angiogenesis Negative Regulation Of Endothelial Cell Proliferation Endothelium Development Small GTPase-mediated Signal Transduction Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Angiogenesis Integrin Activation Cell Redox Homeostasis Regulation Of Angiogenesis Regulation Of Establishment Of Cell Polarity Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		Frs2-mediated activation Frs2-mediated activation ARMS-mediated activation ARMS-mediated activation Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling MAP2K and MAPK activation Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF MET activates RAP1 and RAC1 Signaling downstream of RAS mutants Signaling by RAF1 mutants	None
Diseases		None	Cerebral cavernous malformation
GWAS		Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203 ) Crohn's disease ( 30500874 32581322 ) High altitude adaptation ( 28373541 ) Lymphocyte count ( 32888494 ) Osteoporosis-related phenotypes ( 20548944 )	Coffee consumption ( 31046077 ) Hippocampal volume in Alzheimer's disease dementia ( 29274321 )
Interacting Genes		43 interacting genes: AFDN APBB1IP ARHGEF1 BIN1 BMX BRAF ELOA FADD FAF1 FAS GABARAPL2 GANAB HDAC1 HSPA1A HSPA4 KRIT1 MTNR1A NTRK1 PDE6D PPP2R1A PRKACA RABAC1 RAF1 RALGDS RAP1GAP RAP1GDS1 RAPGEF1 RAPGEF2 RAPGEF3 RAPGEF4 RAPGEF5 RAPGEF6 RASA1 RASA3 RASGRP2 RASGRP4 RASIP1 RGL4 RGS14 RUNDC3A SMARCA2 SMARCA4 TNFRSF10C	7 interacting genes: ITGB1BP1 PLCB3 RAP1A RGS4 TIAM1 TRPV4 UBE2K
Entrez ID		5906	889
HPRD ID		01545	05020
Ensembl ID		ENSG00000116473	ENSG00000001631
Uniprot IDs		A8KAH9 P62834	A4D1F7 O00522
PDB IDs		1C1Y 1GUA 3KUC 4KVG	3U7D 4DX8 4DXA 4HDO 4HDQ 4JIF 4TKN 5D68 6OQ3 6OQ4 6UZK 8SU8 8T09 8T7V
GO Terms Enriched among Interactors		GTPase Regulator Activity Ras Protein Signal Transduction Small GTPase-mediated Signal Transduction Guanyl-nucleotide Exchange Factor Activity Signal Transduction Intracellular Signaling Cassette Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of GTPase Activity Plasma Membrane Establishment Of Endothelial Barrier Endothelial Cell Development Positive Regulation Of GTPase Activity CD95 Death-inducing Signaling Complex Positive Regulation Of Hydrolase Activity Neurotrophin Signaling Pathway Epithelial Cell Development Rap Protein Signal Transduction Regulation Of Microvillus Assembly GTPase Binding Regulation Of Signal Transduction Regulation Of Apoptotic Process Cytosol Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Cell Communication Regulation Of Signaling Small GTPase Binding Nerve Growth Factor Signaling Pathway Establishment Of Endothelial Intestinal Barrier Death-inducing Signaling Complex Assembly Diacylglycerol Binding Regulation Of Programmed Cell Death Regulation Of Catalytic Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling CAMP Binding Fas Signaling Pathway Protein-containing Complex Organization Cytoplasm Positive Regulation Of Cellular Component Biogenesis Regulation Of Developmental Process Protein-containing Complex Assembly GTPase Activator Activity Regulation Of Cellular Component Organization Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Programmed Cell Death Nucleosome Array Spacer Activity Positive Regulation Of Microvillus Assembly Regulation Of Cell Differentiation	Signal Transduction Regulation Of Cell Motility Regulation Of Locomotion Positive Regulation Of Cell-matrix Adhesion Cell Surface Receptor Signaling Pathway Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex Cyclin D2-CDK6 Complex Regulation Of Cell Differentiation FBXO Family Protein Binding Positive Regulation Of Protein Modification Process Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Phosphate Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Regulation Of Phosphorylation Positive Regulation Of Signaling Protein Polymerization Positive Regulation Of Protein Phosphorylation Intracellular Signal Transduction Calmodulin Binding Calcium Ion Transmembrane Import Into Cytosol Regulation Of Neuron Projection Development Regulation Of ERK1 And ERK2 Cascade Response To Antineoplastic Agent Anchoring Junction Negative Regulation Of Glycine Import Across Plasma Membrane Protein Kinase Binding Regulation Of Supramolecular Fiber Organization Osmosensor Activity Blood Vessel Endothelial Cell Delamination Positive Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Stretch-activated, Monoatomic Cation-selective, Calcium Channel Activity Kinase Binding Ruffle Positive Regulation Of Cellular Component Organization Cell-matrix Adhesion Notch Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Dopamine Receptor Signaling Pathway Cellular Hypotonic Salinity Response Vasopressin Secretion Regulation Of Cell-matrix Adhesion Epithelial Cell Development Positive Regulation Of Cell-substrate Adhesion Protein-containing Complex Assembly Positive Regulation Of Protein Kinase Activity