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RAP1A and RABAC1
Number of citations of the paper that reports this interaction (PMID
11335720
)
18
Data Source:
HPRD
(two hybrid, in vivo, in vitro)
RAP1A
RABAC1
Gene Name
RAP1A, member of RAS oncogene family
Rab acceptor 1 (prenylated)
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytoplasm
Early Endosome
Late Endosome
Cytosol
Plasma Membrane
Cell Junction
Guanyl-nucleotide Exchange Factor Complex
Neuron Projection
Perinuclear Region Of Cytoplasm
Extracellular Vesicular Exosome
Golgi Apparatus
Plasma Membrane
Synaptic Vesicle
Membrane
Integral Component Of Membrane
Cell Junction
Molecular Function
GTPase Activity
Protein Binding
GTP Binding
Protein Transporter Activity
Ras GTPase Binding
Rap Guanyl-nucleotide Exchange Factor Activity
Protein Complex Binding
Protein Binding
Protein C-terminus Binding
Identical Protein Binding
Proline-rich Region Binding
Biological Process
Activation Of MAPKK Activity
Energy Reserve Metabolic Process
Signal Transduction
Blood Coagulation
Positive Regulation Of Neuron Projection Development
Protein Transport
Microvillus Assembly
Platelet Activation
Rap Protein Signal Transduction
Positive Regulation Of Rap GTPase Activity
Nerve Growth Factor Signaling Pathway
Small Molecule Metabolic Process
Positive Regulation Of Protein Kinase Activity
Neurotrophin TRK Receptor Signaling Pathway
Regulation Of Insulin Secretion
Establishment Of Endothelial Barrier
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To CAMP
Regulation Of Cell Junction Assembly
Cellular Response To Nerve Growth Factor Stimulus
Negative Regulation Of Synaptic Vesicle Exocytosis
Positive Regulation Of Vasculogenesis
Pathways
Signalling to ERKs
Signalling by NGF
Prolonged ERK activation events
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Integration of energy metabolism
Regulation of insulin secretion
p130Cas linkage to MAPK signaling for integrins
Integrin alphaIIb beta3 signaling
NGF signalling via TRKA from the plasma membrane
GRB2:SOS provides linkage to MAPK signaling for Integrins
Platelet Aggregation (Plug Formation)
ARMS-mediated activation
Rap1 signalling
Platelet activation, signaling and aggregation
Frs2-mediated activation
Adaptive Immune System
Drugs
Diseases
GWAS
Osteoporosis (
20548944
)
Protein-Protein Interactions
41 interactors:
APBB1IP
ARHGEF1
BIN1
BMX
BRAF
FADD
FAF1
FAS
GABARAPL2
GANAB
HDAC1
HSPA1A
KRIT1
MLLT4
MTNR1A
NTRK1
PDE6D
PPP2R1A
PRKACA
RABAC1
RAF1
RALA
RALGDS
RAP1GAP
RAP1GDS1
RAPGEF2
RAPGEF3
RAPGEF4
RAPGEF5
RAPGEF6
RASA1
RASA3
RASGRP2
RASGRP4
RASIP1
RGL4
RGS14
RUNDC3A
SMARCA4
TCEB3
TNFRSF10C
63 interactors:
ADCK3
CMTM3
CREB3
DUSP12
FAM160A2
FXR2
GDI1
HRAS
HRG
LNX1
MAD2L1
MCF2L
MIEF2
NAT14
NDRG4
NIF3L1
NR3C2
NUDT18
PBX3
PLEKHF2
PLK1
RAB17
RAB1A
RAB22A
RAB33A
RAB3A
RAB4A
RAB4B
RAB5A
RAB5B
RAB5C
RAB6A
RAB7A
RAP1A
RASD2
REEP5
RGS2
RHEB
RHOA
RIC8A
RIMS2
RIN3
RPS20
RRAS2
SGK1
SNCA
SNX1
SNX10
SNX11
SNX15
SPG21
SYT16
TNIP1
TRIM32
TSHR
TUBB2A
TXN2
VAMP2
VIM
VTA1
WDYHV1
WIPI2
ZFYVE21
Entrez ID
5906
10567
HPRD ID
01545
05375
Ensembl ID
ENSG00000116473
ENSG00000105404
Uniprot IDs
A8KAH9
P62834
Q9UI14
PDB IDs
1C1Y
1GUA
3KUC
Enriched GO Terms of Interacting Partners
?
Regulation Of Catalytic Activity
Positive Regulation Of Catalytic Activity
Positive Regulation Of Hydrolase Activity
Regulation Of GTPase Activity
Positive Regulation Of GTPase Activity
Positive Regulation Of Metabolic Process
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Rap GTPase Activity
Regulation Of Small GTPase Mediated Signal Transduction
Small GTPase Mediated Signal Transduction
Regulation Of Signaling
Regulation Of Ras Protein Signal Transduction
Regulation Of Ras GTPase Activity
Regulation Of Rap GTPase Activity
Positive Regulation Of Ras GTPase Activity
Intracellular Signal Transduction
Regulation Of Rap Protein Signal Transduction
Signal Transduction
Cell Communication
Regulation Of Metabolic Process
Cellular Response To Stimulus
Signaling
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Response To Stimulus
Ras Protein Signal Transduction
Enzyme Linked Receptor Protein Signaling Pathway
Neurotrophin Signaling Pathway
Regulation Of Cellular Process
Neurotrophin TRK Receptor Signaling Pathway
Regulation Of Cellular Component Organization
Positive Regulation Of Cyclic Nucleotide Metabolic Process
Cellular Response To Growth Factor Stimulus
Response To Growth Factor
Regulation Of Apoptotic Process
Regulation Of Cell Death
Cell Activation
Regulation Of Protein Kinase Activity
Negative Regulation Of Signaling
Regulation Of Kinase Activity
Cell Surface Receptor Signaling Pathway
Platelet Activation
Regulation Of Cell Differentiation
Regulation Of Extrinsic Apoptotic Signaling Pathway
Negative Regulation Of Signal Transduction
Positive Regulation Of Lyase Activity
Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Cell Differentiation
Ras Protein Signal Transduction
Rab Protein Signal Transduction
Small GTPase Mediated Signal Transduction
Establishment Of Protein Localization
Protein Transport
Protein Localization
Cellular Protein Localization
Cellular Localization
Intracellular Protein Transport
Regulation Of Cellular Component Organization
Regulation Of Vesicle-mediated Transport
Vesicle-mediated Transport
Establishment Of Localization In Cell
Intracellular Transport
Intracellular Signal Transduction
Endosomal Transport
Regulation Of Exocytosis
Transport
Cellular Response To Stimulus
Cell Communication
Regulation Of Endocytosis
Endocytosis
Regulation Of Locomotion
Vesicle Organization
Endosome Organization
Response To Stimulus
Regulation Of Synaptic Vesicle Transport
Regulation Of Cell Projection Organization
Signaling
Signal Transduction
Cytoplasmic Transport
Establishment Of Vesicle Localization
Regulation Of Neuronal Synaptic Plasticity
Vesicle Localization
Regulation Of Organelle Organization
Regulation Of Cell Migration
Positive Regulation Of Metabolic Process
Early Endosome To Late Endosome Transport
Regulation Of Neurotransmitter Secretion
Regulation Of Cell Motility
Regulation Of Signaling
Regulation Of Cellular Localization
Regulation Of Cellular Component Movement
Regulation Of Cellular Process
Regulation Of Synaptic Plasticity
Regulation Of Long-term Neuronal Synaptic Plasticity
Regulation Of Synaptic Vesicle Exocytosis
Positive Regulation Of Transport
Synaptic Vesicle Recycling
Endomembrane System Organization
Tagcloud
?
bfa
bisphosphonates
brefeldin
camp
cathepsin
cdc42
cytoskeletal
diminish
diminished
epac
epac1
epac2
esi
fak
intermediates
isoprenylation
ko
multinucleated
nfatc1
nfkb
osteoclast
osteopontin
pctp
permit
rac1
rankl
raw264
rhoa
Tagcloud (Difference)
?
bfa
bisphosphonates
brefeldin
camp
cathepsin
cdc42
cytoskeletal
diminish
diminished
epac
epac1
epac2
esi
fak
intermediates
isoprenylation
ko
multinucleated
nfatc1
nfkb
osteoclast
osteopontin
pctp
permit
rac1
rankl
raw264
rhoa
Tagcloud (Intersection)
?