RAP1A and RASGRP4

Number of citations of the paper that reports this interaction (PubMedID 11880369)
0

Data Source:
HPRD (in vitro)

		RAP1A	RASGRP4
Description		RAP1A, member of RAS oncogene family	RAS guanyl releasing protein 4
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GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Late Endosome Cytosol Plasma Membrane Endosome Membrane Membrane Cell Junction Guanyl-nucleotide Exchange Factor Complex Specific Granule Membrane Neuron Projection Phagocytic Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome Anchoring Junction Sperm Midpiece Presynapse Glutamatergic Synapse	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Small GTPase Binding Protein-containing Complex Binding	Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding Zinc Ion Binding Lipid Binding Diacylglycerol Binding GTPase Regulator Activity Metal Ion Binding
	Biological Process	Signal Transduction Small GTPase-mediated Signal Transduction Nervous System Development Response To Carbohydrate Positive Regulation Of Neuron Projection Development Synaptic Vesicle Exocytosis Rap Protein Signal Transduction Negative Regulation Of Collagen Biosynthetic Process Nerve Growth Factor Signaling Pathway Positive Regulation Of GTPase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of D-glucose Import Positive Regulation Of Phagocytosis Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Protein Localization To Plasma Membrane Response To Antineoplastic Agent Liver Regeneration Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Cell Junction Assembly Cellular Response To Forskolin Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Vasculogenesis	Positive Regulation Of Natural Killer Cell Mediated Immunity Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Myeloid Cell Differentiation Cell Differentiation Antibacterial Innate Immune Response
Pathways		Frs2-mediated activation Frs2-mediated activation ARMS-mediated activation ARMS-mediated activation Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling MAP2K and MAPK activation Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF MET activates RAP1 and RAC1 Signaling downstream of RAS mutants Signaling by RAF1 mutants	FCERI mediated NF-kB activation RAF/MAP kinase cascade
Drugs
Diseases
GWAS		Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Crohn's disease ( 30500874 32581322) High altitude adaptation ( 28373541) Lymphocyte count ( 32888494) Osteoporosis-related phenotypes ( 20548944)	Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Diisocyanate-induced asthma ( 25918132) Eosinophil count ( 27863252 32888494) Eosinophil percentage of white cells ( 27863252 32888494) Monocyte count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		43 interacting genes: AFDN APBB1IP ARHGEF1 BIN1 BMX BRAF ELOA FADD FAF1 FAS GABARAPL2 GANAB HDAC1 HSPA1A HSPA4 KRIT1 MTNR1A NTRK1 PDE6D PPP2R1A PRKACA RABAC1 RAF1 RALGDS RAP1GAP RAP1GDS1 RAPGEF1 RAPGEF2 RAPGEF3 RAPGEF4 RAPGEF5 RAPGEF6 RASA1 RASA3 RASGRP2 RASGRP4 RASIP1 RGL4 RGS14 RUNDC3A SMARCA2 SMARCA4 TNFRSF10C	6 interacting genes: BNIP2 DYNLL1 HRAS RAP1A SEC22A TMPRSS4
Entrez ID		5906	115727
HPRD ID		01545	09540
Ensembl ID		ENSG00000116473	ENSG00000171777
Uniprot IDs		A8KAH9 P62834	Q8TDF6
PDB IDs		1C1Y 1GUA 3KUC 4KVG	6AXG
Enriched GO Terms of Interacting Partners?		GTPase Regulator Activity Ras Protein Signal Transduction Small GTPase-mediated Signal Transduction Guanyl-nucleotide Exchange Factor Activity Signal Transduction Intracellular Signaling Cassette Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of GTPase Activity Plasma Membrane Establishment Of Endothelial Barrier Endothelial Cell Development Positive Regulation Of GTPase Activity CD95 Death-inducing Signaling Complex Positive Regulation Of Hydrolase Activity Neurotrophin Signaling Pathway Epithelial Cell Development Rap Protein Signal Transduction Regulation Of Microvillus Assembly GTPase Binding Regulation Of Signal Transduction Regulation Of Apoptotic Process Cytosol Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Cell Communication Regulation Of Signaling Small GTPase Binding Nerve Growth Factor Signaling Pathway Establishment Of Endothelial Intestinal Barrier Death-inducing Signaling Complex Assembly Diacylglycerol Binding Regulation Of Programmed Cell Death Regulation Of Catalytic Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling CAMP Binding Fas Signaling Pathway Protein-containing Complex Organization Cytoplasm Positive Regulation Of Cellular Component Biogenesis Regulation Of Developmental Process Protein-containing Complex Assembly GTPase Activator Activity Regulation Of Cellular Component Organization Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Programmed Cell Death Nucleosome Array Spacer Activity Positive Regulation Of Microvillus Assembly Regulation Of Cell Differentiation	Regulation Of Receptor Localization To Synapse Regulation Of Protein Localization To Synapse Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of MAPK Cascade GDP Binding G Protein Activity Negative Regulation Of Growth Rate Regulation Of Cellular Localization GTPase Complex Response To Antineoplastic Agent Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Secretory Granule Regulation Of MAPK Cascade Phospholipase C Activator Activity Deoxyribonuclease Inhibitor Activity Regulation Of DNA Strand Resection Involved In Replication Fork Processing Nitric-oxide Synthase Inhibitor Activity Perinuclear Region Of Cytoplasm Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Protein Localization To Membrane Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Growth Rate Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of Synaptic Vesicle Exocytosis Apoptotic Process Oncogene-induced Cell Senescence Cell Development Guanyl-nucleotide Exchange Factor Complex Cell Death Programmed Cell Death Regulation Of Protein Localization Nitric-oxide Synthase Regulator Activity Positive Regulation Of Intracellular Signal Transduction Spindle Pole Centrosome Response To Oxygen-glucose Deprivation GTPase Activity Regulation Of ERK1 And ERK2 Cascade Vesicle-mediated Transport Positive Regulation Of Ruffle Assembly Small GTPase-mediated Signal Transduction T-helper 1 Type Immune Response Positive Regulation Of Establishment Of Protein Localization Negative Regulation Of Collagen Biosynthetic Process Cellular Response To Forskolin Rap Protein Signal Transduction Positive Regulation Of Vasculogenesis Nerve Growth Factor Signaling Pathway Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway
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