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RAP1A and RAPGEF2
Number of citations of the paper that reports this interaction (PubMedID
10934204
)
0
Data Source:
HPRD
(in vitro, in vivo)
RAP1A
RAPGEF2
Description
RAP1A, member of RAS oncogene family
Rap guanine nucleotide exchange factor 2
Image
GO Annotations
Cellular Component
Cytoplasm
Endosome
Early Endosome
Late Endosome
Cytosol
Plasma Membrane
Endosome Membrane
Membrane
Cell Junction
Guanyl-nucleotide Exchange Factor Complex
Specific Granule Membrane
Neuron Projection
Phagocytic Vesicle
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Anchoring Junction
Sperm Midpiece
Presynapse
Glutamatergic Synapse
Cytoplasm
Endosome
Late Endosome
Cytosol
Plasma Membrane
Cell-cell Junction
Bicellular Tight Junction
Membrane
Apical Plasma Membrane
Endocytic Vesicle
Protein-containing Complex
Neuron Projection
Neuronal Cell Body
Synapse
Perinuclear Region Of Cytoplasm
Anchoring Junction
Molecular Function
Nucleotide Binding
GTPase Activity
G Protein Activity
Guanyl-nucleotide Exchange Factor Activity
Protein Binding
GTP Binding
Hydrolase Activity
GDP Binding
Small GTPase Binding
Protein-containing Complex Binding
Guanyl-nucleotide Exchange Factor Activity
GTPase Activator Activity
Calcium Ion Binding
Protein Binding
Diacylglycerol Binding
PDZ Domain Binding
CAMP Binding
CGMP Binding
Beta-1 Adrenergic Receptor Binding
WW Domain Binding
Phosphatidic Acid Binding
Biological Process
Signal Transduction
Small GTPase-mediated Signal Transduction
Nervous System Development
Response To Carbohydrate
Positive Regulation Of Neuron Projection Development
Synaptic Vesicle Exocytosis
Rap Protein Signal Transduction
Negative Regulation Of Collagen Biosynthetic Process
Nerve Growth Factor Signaling Pathway
Positive Regulation Of GTPase Activity
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of D-glucose Import
Positive Regulation Of Phagocytosis
Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway
Establishment Of Endothelial Barrier
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To CAMP
Protein Localization To Plasma Membrane
Response To Antineoplastic Agent
Liver Regeneration
Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane
Regulation Of Cell Junction Assembly
Cellular Response To Forskolin
Cellular Response To Nerve Growth Factor Stimulus
Negative Regulation Of Synaptic Vesicle Exocytosis
Positive Regulation Of Vasculogenesis
MAPK Cascade
Blood Vessel Development
Neuron Migration
Signal Transduction
G Protein-coupled Receptor Signaling Pathway
Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway
Neuropeptide Signaling Pathway
Small GTPase-mediated Signal Transduction
Ras Protein Signal Transduction
Nervous System Development
Negative Regulation Of Cell Population Proliferation
Regulation Of Neuron Projection Development
Positive Regulation Of Neuron Projection Development
CAMP-mediated Signaling
Ventricular System Development
Forebrain Neuron Development
Microvillus Assembly
Cell Differentiation
Neuron Projection Development
Brain-derived Neurotrophic Factor Receptor Signaling Pathway
Positive Regulation Of Protein Binding
Rap Protein Signal Transduction
Intracellular Signal Transduction
Nerve Growth Factor Signaling Pathway
Positive Regulation Of GTPase Activity
Positive Regulation Of Protein Kinase Activity
Negative Regulation Of Melanin Biosynthetic Process
Regulation Of Synaptic Plasticity
Negative Regulation Of Dendrite Morphogenesis
Establishment Of Endothelial Barrier
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To CAMP
Cellular Response To CGMP
Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway
Protein Localization To Plasma Membrane
Establishment Of Endothelial Intestinal Barrier
Regulation Of Cell Junction Assembly
Positive Regulation Of Microvillus Assembly
Cellular Response To Nerve Growth Factor Stimulus
Positive Regulation Of CAMP-dependent Protein Kinase Activity
Positive Regulation Of Dendritic Cell Apoptotic Process
Positive Regulation Of Vasculogenesis
Positive Regulation Of Neuron Migration
Pathways
Frs2-mediated activation
Frs2-mediated activation
ARMS-mediated activation
ARMS-mediated activation
Integrin signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Rap1 signalling
MAP2K and MAPK activation
Neutrophil degranulation
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF1 fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
MET activates RAP1 and RAC1
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
RAF/MAP kinase cascade
Drugs
Diseases
GWAS
Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) (
31374203
)
Crohn's disease (
30500874
32581322
)
High altitude adaptation (
28373541
)
Lymphocyte count (
32888494
)
Osteoporosis-related phenotypes (
20548944
)
Dietary fat liking (
32516399
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Molybdenum levels (
26025379
)
Uterine fibroid number (single vs multiple) (
30196971
)
Interacting Genes
43 interacting genes:
AFDN
APBB1IP
ARHGEF1
BIN1
BMX
BRAF
ELOA
FADD
FAF1
FAS
GABARAPL2
GANAB
HDAC1
HSPA1A
HSPA4
KRIT1
MTNR1A
NTRK1
PDE6D
PPP2R1A
PRKACA
RABAC1
RAF1
RALGDS
RAP1GAP
RAP1GDS1
RAPGEF1
RAPGEF2
RAPGEF3
RAPGEF4
RAPGEF5
RAPGEF6
RASA1
RASA3
RASGRP2
RASGRP4
RASIP1
RGL4
RGS14
RUNDC3A
SMARCA2
SMARCA4
TNFRSF10C
14 interacting genes:
CTNNB1
DYRK1A
HSPA1A
IL16
KIF5A
KIF5B
MAGI2
MOB4
MT-ATP8
NEDD4
RALGDS
RAP1A
RAP2B
SPP1
Entrez ID
5906
9693
HPRD ID
01545
19358
Ensembl ID
ENSG00000116473
ENSG00000109756
Uniprot IDs
A8KAH9
P62834
A0A994J7S7
Q9Y4G8
PDB IDs
1C1Y
1GUA
3KUC
4KVG
6QDT
Enriched GO Terms of Interacting Partners
?
GTPase Regulator Activity
Ras Protein Signal Transduction
Small GTPase-mediated Signal Transduction
Guanyl-nucleotide Exchange Factor Activity
Signal Transduction
Intracellular Signaling Cassette
Intracellular Signal Transduction
Regulation Of Intracellular Signal Transduction
Regulation Of GTPase Activity
Plasma Membrane
Establishment Of Endothelial Barrier
Endothelial Cell Development
Positive Regulation Of GTPase Activity
CD95 Death-inducing Signaling Complex
Positive Regulation Of Hydrolase Activity
Neurotrophin Signaling Pathway
Epithelial Cell Development
Rap Protein Signal Transduction
Regulation Of Microvillus Assembly
GTPase Binding
Regulation Of Signal Transduction
Regulation Of Apoptotic Process
Cytosol
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Regulation Of Cell Communication
Regulation Of Signaling
Small GTPase Binding
Nerve Growth Factor Signaling Pathway
Establishment Of Endothelial Intestinal Barrier
Death-inducing Signaling Complex Assembly
Diacylglycerol Binding
Regulation Of Programmed Cell Death
Regulation Of Catalytic Activity
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
CAMP Binding
Fas Signaling Pathway
Protein-containing Complex Organization
Cytoplasm
Positive Regulation Of Cellular Component Biogenesis
Regulation Of Developmental Process
Protein-containing Complex Assembly
GTPase Activator Activity
Regulation Of Cellular Component Organization
Regulation Of Apoptotic Signaling Pathway
Regulation Of Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of Programmed Cell Death
Nucleosome Array Spacer Activity
Positive Regulation Of Microvillus Assembly
Regulation Of Cell Differentiation
Perinuclear Region Of Cytoplasm
Postsynaptic Cytosol
Synaptic Vesicle Transport
Retrograde Neuronal Dense Core Vesicle Transport
Regulation Of Transport
Ciliary Rootlet
Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex
Anterograde Axonal Protein Transport
Dense Core Granule Cytoskeletal Transport
Rap Protein Signal Transduction
Anterograde Dendritic Transport
Protein Transport Along Microtubule
Nerve Growth Factor Signaling Pathway
Nervous System Development
Establishment Of Vesicle Localization
Dendritic Transport
Plus-end-directed Microtubule Motor Activity
Bicellular Tight Junction
Vesicle Localization
Regulation Of Inclusion Body Assembly
Retrograde Axonal Transport
Secretory Granule Localization
Neuron Projection
Regulation Of Metal Ion Transport
Epithelial Cell Development
Apicolateral Plasma Membrane
Disordered Domain Specific Binding
Dendrite Cytoplasm
Intracellular Signal Transduction
Neurotrophin Signaling Pathway
Regulation Of Cellular Component Organization
Negative Regulation Of Intracellular Signal Transduction
Regulation Of Monoatomic Ion Transport
Regulation Of Neuron Projection Development
Positive Regulation Of Transport
Vesicle
Regulation Of Cell Communication
Regulation Of Signaling
Establishment Of Endothelial Barrier
Intracellular Signaling Cassette
Regulation Of Intracellular Signal Transduction
Negative Regulation Of Signal Transduction
Endothelial Cell Development
Positive Regulation Of RNA Splicing
Cellular Response To Nerve Growth Factor Stimulus
Vesicle Transport Along Microtubule
Kinesin Complex
Anterograde Axonal Transport
Response To Nerve Growth Factor
Cytoskeleton
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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