RAP1A and TCEB3

Number of citations of the paper that reports this interaction (PMID 15207703)
1

Data Source:
HPRD (in vivo)

		RAP1A	TCEB3
Gene Name		RAP1A, member of RAS oncogene family	transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A)
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Gene Ontology Annotations	Cellular Component	Cytoplasm Early Endosome Late Endosome Cytosol Plasma Membrane Cell Junction Guanyl-nucleotide Exchange Factor Complex Neuron Projection Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Extracellular Space Nucleus Nucleoplasm Cytoplasm Integral Component Of Membrane
	Molecular Function	GTPase Activity Protein Binding GTP Binding Protein Transporter Activity Ras GTPase Binding Rap Guanyl-nucleotide Exchange Factor Activity Protein Complex Binding	DNA Binding
	Biological Process	Activation Of MAPKK Activity Energy Reserve Metabolic Process Signal Transduction Blood Coagulation Positive Regulation Of Neuron Projection Development Protein Transport Microvillus Assembly Platelet Activation Rap Protein Signal Transduction Positive Regulation Of Rap GTPase Activity Nerve Growth Factor Signaling Pathway Small Molecule Metabolic Process Positive Regulation Of Protein Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Insulin Secretion Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Regulation Of Cell Junction Assembly Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Vasculogenesis	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Gene Expression Viral Process Positive Regulation Of Viral Transcription
Pathways		Signalling to ERKs Signalling by NGF Prolonged ERK activation events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Integration of energy metabolism Regulation of insulin secretion p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling NGF signalling via TRKA from the plasma membrane GRB2:SOS provides linkage to MAPK signaling for Integrins Platelet Aggregation (Plug Formation) ARMS-mediated activation Rap1 signalling Platelet activation, signaling and aggregation Frs2-mediated activation Adaptive Immune System	Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription HIV Infection Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery RNA Polymerase II Pre-transcription Events Late Phase of HIV Life Cycle Pausing and recovery of Tat-mediated HIV elongation Formation of RNA Pol II elongation complex HIV elongation arrest and recovery HIV Life Cycle Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat HIV Transcription Elongation Transcription of the HIV genome RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Osteoporosis ( 20548944)
Protein-Protein Interactions		41 interactors: APBB1IP ARHGEF1 BIN1 BMX BRAF FADD FAF1 FAS GABARAPL2 GANAB HDAC1 HSPA1A KRIT1 MLLT4 MTNR1A NTRK1 PDE6D PPP2R1A PRKACA RABAC1 RAF1 RALA RALGDS RAP1GAP RAP1GDS1 RAPGEF2 RAPGEF3 RAPGEF4 RAPGEF5 RAPGEF6 RASA1 RASA3 RASGRP2 RASGRP4 RASIP1 RGL4 RGS14 RUNDC3A SMARCA4 TCEB3 TNFRSF10C	21 interactors: BRCA1 CEP57L1 CEP70 FAM9B GMCL1 HOMEZ JAKMIP2 KRT40 KRTAP10-3 MDFI MED21 MID2 NINL PLK4 POLR2A RAD54B RAP1A REXO1 SPERT TCEB2 TRIM54
Entrez ID		5906	6924
HPRD ID		01545	02873
Ensembl ID		ENSG00000116473	ENSG00000011007
Uniprot IDs		A8KAH9 P62834	Q14241
PDB IDs		1C1Y 1GUA 3KUC	4HFX
Enriched GO Terms of Interacting Partners?		Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Hydrolase Activity Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Rap GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Small GTPase Mediated Signal Transduction Regulation Of Signaling Regulation Of Ras Protein Signal Transduction Regulation Of Ras GTPase Activity Regulation Of Rap GTPase Activity Positive Regulation Of Ras GTPase Activity Intracellular Signal Transduction Regulation Of Rap Protein Signal Transduction Signal Transduction Cell Communication Regulation Of Metabolic Process Cellular Response To Stimulus Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Stimulus Ras Protein Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Cellular Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Cyclic Nucleotide Metabolic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Apoptotic Process Regulation Of Cell Death Cell Activation Regulation Of Protein Kinase Activity Negative Regulation Of Signaling Regulation Of Kinase Activity Cell Surface Receptor Signaling Pathway Platelet Activation Regulation Of Cell Differentiation Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Lyase Activity Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cell Differentiation	Regulation Of Viral Transcription Regulation Of Centriole Replication Trophoblast Giant Cell Differentiation G2/M Transition Of Mitotic Cell Cycle Regulation Of Microtubule Cytoskeleton Organization Regulation Of Viral Process Regulation Of Microtubule-based Process Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Centrosome Duplication Cell Cycle Process Positive Regulation Of Viral Transcription Regulation Of Centrosome Cycle Centrosome Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of Viral Process Microtubule-based Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Positive Regulation Of Centriole Replication Transcription, RNA-templated Positive Regulation Of Histone H3-K9 Acetylation Cell Cycle DNA-templated Transcription, Elongation Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Centrosome Organization Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Cellular Response To Stress Microtubule Organizing Center Organization Embryonic Placenta Development Microtubule Cytoskeleton Organization Cellular Response To Indole-3-methanol Regulation Of Transcription, DNA-templated Maintenance Of Protein Location In Cell Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Maintenance Of Protein Location Negative Regulation Of Centriole Replication Positive Regulation Of Centrosome Duplication Maintenance Of Location In Cell Cell Differentiation Regulation Of Cytoskeleton Organization Response To Stress Regulation Of RNA Metabolic Process In Utero Embryonic Development
Tagcloud ?		bfa bisphosphonates brefeldin camp cathepsin cdc42 cytoskeletal diminish diminished epac epac1 epac2 esi fak intermediates isoprenylation ko multinucleated nfatc1 nfkb osteoclast osteopontin pctp permit rac1 rankl raw264 rhoa	anomalies cleft clefts cnv cnvs comprise disrupting doi etiology fgf8 foxe1 gli2 grouped highlighting irf6 jhg journal kif7 lip mentioned msx1 msx2 ofc ofcs orofacial palate postulated satb2 ski
Tagcloud (Difference) ?		bfa bisphosphonates brefeldin camp cathepsin cdc42 cytoskeletal diminish diminished epac epac1 epac2 esi fak intermediates isoprenylation ko multinucleated nfatc1 nfkb osteoclast osteopontin pctp permit rac1 rankl raw264 rhoa	anomalies cleft clefts cnv cnvs comprise disrupting doi etiology fgf8 foxe1 gli2 grouped highlighting irf6 jhg journal kif7 lip mentioned msx1 msx2 ofc ofcs orofacial palate postulated satb2 ski
Tagcloud (Intersection) ?