TLN1 and YWHAQ

Number of citations of the paper that reports this interaction (PMID 15161933)
63

Data Source:
BioGRID (pull down)

		TLN1	YWHAQ
Gene Name		talin 1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
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Gene Ontology Annotations	Cellular Component	Ruffle Extracellular Region Cytoplasm Microtubule Organizing Center Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Cell Surface Ruffle Membrane Extracellular Vesicular Exosome	Cytoplasm Cytosol Focal Adhesion Membrane Cytoplasmic Vesicle Membrane Extracellular Vesicular Exosome
	Molecular Function	Insulin Receptor Binding Integrin Binding Structural Constituent Of Cytoskeleton Protein Binding Vinculin Binding LIM Domain Binding Actin Filament Binding	Protein Binding Protein Domain Specific Binding Protein N-terminus Binding
	Biological Process	Platelet Degranulation Movement Of Cell Or Subcellular Component Muscle Contraction Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Cytoskeletal Anchoring At Plasma Membrane Cell-cell Junction Assembly Cell-substrate Junction Assembly Axon Guidance Blood Coagulation Platelet Activation Cortical Actin Cytoskeleton Organization Endoplasmic Reticulum Unfolded Protein Response Cellular Protein Metabolic Process Platelet Aggregation	Protein Targeting Apoptotic Process Small GTPase Mediated Signal Transduction Substantia Nigra Development Negative Regulation Of Transcription, DNA-templated Membrane Organization Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Pathways		Axon guidance Semaphorin interactions p130Cas linkage to MAPK signaling for integrins Smooth Muscle Contraction Integrin alphaIIb beta3 signaling Platelet degranulation GRB2:SOS provides linkage to MAPK signaling for Integrins Platelet Aggregation (Plug Formation) XBP1(S) activates chaperone genes IRE1alpha activates chaperones Response to elevated platelet cytosolic Ca2+ SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Platelet activation, signaling and aggregation Unfolded Protein Response (UPR)	Activation of BAD and translocation to mitochondria Programmed Cell Death Translocation of GLUT4 to the plasma membrane Activation of BH3-only proteins Intrinsic Pathway for Apoptosis
Drugs
Diseases
GWAS			Heart rate variability traits ( 22174390)
Protein-Protein Interactions		23 interactors: ACTA1 CDK5 DAG1 EGFR ERBB2 ITGA1 ITGA2B ITGB1 ITGB2 ITGB3 ITGB5 ITGB7 LRP2 NRAP PKD1 PTK2 PTK2B PXN SMURF1 TES TUBA1A VCL YWHAQ	231 interactors: AARS2 ABL1 ACSL4 AHCY AKT1S1 ANXA1 ANXA2 APC AR ARHGAP10 ARHGEF16 ATP5A1 BAD BAX BCAP31 BCR BRAF CABIN1 CAPN3 CBL CBLL1 CDC25A CDC25B CDC25C CDC5L CDK11B CDK14 CDK16 CDK17 CDK18 CDKN1A CDKN1B CEP170 CFL1 CHAF1A CKM CLTC COPS4 CSE1L CSNK1A1 CSNK2A1 CTPS1 DAB2IP DCPS DDX1 DDX3X DHX9 DISC1 DNMT1 DYNC1H1 E2F1 EFNB1 EIF4A3 ENO1 EPB41 EPB41L1 EPB41L3 ESR1 ESR2 EXO1 FASN FBLN1 FGR FSCN1 FSHR FXYD1 GAPDH GCN1L1 HADHA HAT1 HAX1 HDAC4 HDAC5 HDAC7 HIST1H2BG HIST2H4A HNRNPA1 HNRNPC HNRNPF HNRNPH1 HNRNPK HSPA1A HSPA8 HUS1 IARS2 ING1 IQGAP1 IRS2 ITGB4 KCNK15 KCNK3 KCNK9 KIAA1429 KIF1C KIF23 KIF5B KLC2 KLC3 KRT1 KRT9 LARP1 LARS2 LDHA LIMA1 LMNA LMNB1 LMO7 LYST MAGOH MAP3K3 MAP3K5 MARK2 MARK3 MCM3 MDM4 MED1 MEF2D MPL MPRIP MRPS27 MST1R MTNR1B MTOR MYCBP2 NADK NCL NCOA1 NCOA3 NDE1 NFATC1 NFATC2 NFATC4 NFKB1 NIF3L1 NME7 NOLC1 NUMA1 PABPC4 PABPN1 PAK4 PANK1 PCM1 PDCD6 PDE3A PDE3B PDK1 PDPK1 PDXK PFKFB2 PFKL PFN1 PGK1 PHLDB2 PI4KB PIK3C2B PIK3C3 PIK3CB PKM PPFIBP1 PRDX1 PRKCQ PRKCZ PRKD1 PRKDC PRMT5 PSME3 PTPN3 RAF1 RAI14 RCOR3 REM1 RFC1 RGS3 RGS7 RNASE2 RPL10A RPL15 RPL19 RPL7 RPLP0 RPLP2 RPS3 RUVBL2 SAMSN1 SH3BP2 SLC27A2 SLC8A1 SLC8A2 SLC8A3 SMAD9 SNRPE SPR SPTA1 SPTB SRSF3 SSBP1 SSFA2 SSX2IP TCP1 TERT THRA TLN1 TNF TNFAIP3 TP53BP2 TPI1 TPR TRIM28 TRIM42 TSC1 TSC2 TUBA1A TUBA3C TUBB UBQLN4 UCP2 UCP3 ULK4 USP8 VARS WDR61 WDR77 WEE1 WTAP WWC2 WWP1 YAP1 YWHAE YWHAG ZC3H13 ZHX2
Entrez ID		7094	10971
HPRD ID		01726	00886
Ensembl ID		ENSG00000137076	ENSG00000134308
Uniprot IDs		Q9Y490	B4DMT8 P27348
PDB IDs		1SYQ 4DJ9	2BTP
Enriched GO Terms of Interacting Partners?		Cell-matrix Adhesion Cell-substrate Adhesion Integrin-mediated Signaling Pathway Movement Of Cell Or Subcellular Component Cell Adhesion Cell Morphogenesis Involved In Differentiation Anatomical Structure Morphogenesis Response To External Stimulus Cell Differentiation Axonogenesis Anatomical Structure Development Extracellular Matrix Organization Extracellular Structure Organization Axon Development Cell Morphogenesis Axon Guidance Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Development Regulation Of Cell Migration Chemotaxis Cell Development Cell Projection Organization Neuron Projection Morphogenesis Regulation Of Cell Motility Developmental Process Multicellular Organismal Development Positive Regulation Of Protein Kinase Activity Regulation Of Locomotion Locomotion Neuron Development Regulation Of Cellular Component Movement Positive Regulation Of Kinase Activity Positive Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Single Organismal Cell-cell Adhesion Regulation Of Protein Phosphorylation Positive Regulation Of Transferase Activity Neuron Differentiation Cell Projection Morphogenesis Nervous System Development Regulation Of Phosphorus Metabolic Process Cell Part Morphogenesis Positive Regulation Of Phosphorylation Wound Healing Positive Regulation Of Protein Modification Process Generation Of Neurons Blood Coagulation Cellular Localization Hemostasis Heterotypic Cell-cell Adhesion	Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Cellular Metabolic Process Organelle Organization Cellular Process Cellular Response To Organic Substance Regulation Of Cellular Component Organization Response To Organic Substance Response To Stimulus Positive Regulation Of Cellular Metabolic Process Developmental Process Positive Regulation Of Metabolic Process Regulation Of Cell Death Mitotic Cell Cycle Regulation Of Metabolic Process Response To Stress Cell Cycle Cellular Response To Stimulus Mitotic Cell Cycle Process Death Regulation Of Apoptotic Process Programmed Cell Death Regulation Of Protein Localization Intracellular Signal Transduction Apoptotic Process Cell Cycle Process Anatomical Structure Development Cell Death Regulation Of Cellular Localization System Development Multicellular Organismal Development Regulation Of Establishment Of Protein Localization Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Regulation Of Cell Cycle Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Abiotic Stimulus Positive Regulation Of Protein Metabolic Process Intracellular Transport Regulation Of Signaling Nucleobase-containing Compound Metabolic Process Cellular Response To Stress Regulation Of Phosphorylation Innate Immune Response MRNA Metabolic Process Cellular Localization Immune System Process Regulation Of Kinase Activity
Tagcloud ?		83a adjacent brainstem clu comprehensive correlating dipg dipgs ef2 fresh frozen glioma h3f3a hedgehog hh hist1h3b hypomethylation morbid multidimensional pediatric pontine profiling ptch signatures specimens subgroups supervised talin upregulation
Tagcloud (Difference) ?		83a adjacent brainstem clu comprehensive correlating dipg dipgs ef2 fresh frozen glioma h3f3a hedgehog hh hist1h3b hypomethylation morbid multidimensional pediatric pontine profiling ptch signatures specimens subgroups supervised talin upregulation
Tagcloud (Intersection) ?