TLN1 and DOK1

Number of citations of the paper that reports this interaction (PubMedID 19843520)
61

Data Source:
BioGRID (pull down)

		TLN1	DOK1
Description		talin 1	docking protein 1
Image
GO Annotations	Cellular Component	Ruffle Extracellular Region Cytoplasm Cytosol Cytoskeleton Plasma Membrane Adherens Junction Focal Adhesion Cell Surface Membrane Ruffle Membrane Cell Projection Extracellular Exosome Anchoring Junction	Nucleus Cytoplasm Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Phosphatidylserine Binding Actin Binding Integrin Binding Structural Constituent Of Cytoskeleton Protein Binding Vinculin Binding LIM Domain Binding Phosphatidylinositol Binding Cadherin Binding Actin Filament Binding	Protein Binding
	Biological Process	Cell-cell Junction Assembly Cell-substrate Junction Assembly Cell Adhesion Integrin-mediated Signaling Pathway Actin Cytoskeleton Organization Cortical Actin Cytoskeleton Organization Integrin Activation Cortical Microtubule Organization Regulation Of Focal Adhesion Assembly Platelet Aggregation Cell-cell Adhesion	Signal Transduction Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction Intracellular Signal Transduction Macrophage Colony-stimulating Factor Signaling Pathway
Pathways		Platelet degranulation Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins XBP1(S) activates chaperone genes SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Smooth Muscle Contraction MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 RET signaling
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) IgE levels in asthmatics ( 23967269) Lymphocyte count ( 32888494) Monocyte count ( 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 32888494)	Bell's palsy ( 33602968) Height ( 31562340)
Interacting Genes		37 interacting genes: ABI1 ACTA1 ARHGAP31 AZIN2 CDK5 CEBPA DAG1 DOK1 EGFR ERBB2 FMO1 HSP90AA1 ITGA1 ITGA2B ITGB1 ITGB2 ITGB3 ITGB5 ITGB7 LRP2 MTNR1A MTNR1B NRAP NYAP1 PIP5K1C PKD1 PTK2 PTK2B PXN RET SMURF1 SUMO2 TES TPTE TUBA1A VCL YWHAQ	41 interacting genes: ABL1 ABL2 BCR CRK CRKL CSK DOK3 ERBB2 FES FGR FYN GRB10 HCK INPP5D INSR ITGB1 ITGB2 ITGB3 ITGB5 ITGB7 ITK KIT LCK LYN MAP4K4 NCK1 NCK2 PIK3R1 PLCG1 PTK6 PTPN6 PTPRH RASA1 RET SH2D1A SHC1 SRC TEC TLN1 VAV1 YES1
Entrez ID		7094	1796
HPRD ID		01726	04228
Ensembl ID		ENSG00000137076	ENSG00000115325
Uniprot IDs		Q9Y490	B3KP83 B4DJN1 Q14CB2 Q2TA81 Q99704
PDB IDs		1SYQ 2MWN 4DJ9 6R9T	2V76
Enriched GO Terms of Interacting Partners?		Focal Adhesion Cell-matrix Adhesion Cell-substrate Adhesion Integrin Complex Integrin-mediated Signaling Pathway Cell Migration Receptor Complex Cell Motility Cell Adhesion Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Signal Transduction Cell Adhesion Mediated By Integrin Lamellipodium Enzyme-linked Receptor Protein Signaling Pathway Filopodium Virus Receptor Activity Regulation Of Protein Metabolic Process Cell Surface Anchoring Junction Cell Projection Symbiont Entry Into Host Cell Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Plasma Membrane Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Extracellular Exosome Signal Complex Assembly Developmental Process Integrin Binding Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Protein Metabolic Process Heterotypic Cell-cell Adhesion Biological Process Involved In Interaction With Host Neuron Projection Morphogenesis Protein Phosphatase Binding Vinculin Binding Cell Projection Morphogenesis Cell Projection Organization Ruffle Membrane Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Wound Healing, Spreading Of Epidermal Cells Integrin Alpha1-beta1 Complex Regulation Of Cell Migration Positive Regulation Of Fibroblast Migration Regulation Of Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Adhesion Anatomical Structure Morphogenesis Regulation Of Cell-matrix Adhesion Regulation Of Cell Development	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Tyrosine Kinase Activity Cell Surface Receptor Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Phosphotyrosine Residue Binding Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune System Process Cell Migration Regulation Of Cell Adhesion Regulation Of Immune System Process Peptidyl-tyrosine Phosphorylation Fc Receptor Signaling Pathway Cell Motility Positive Regulation Of Cell Adhesion Immune Response-regulating Signaling Pathway Protein Kinase Activity Regulation Of Immune Response Protein Phosphorylation Kinase Activity Immune Response-activating Signaling Pathway Plasma Membrane Leukocyte Migration Integrin-mediated Signaling Pathway Phosphorylation Immune System Process Activation Of Immune Response Fc-gamma Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Immune Response Fc Receptor Mediated Stimulatory Signaling Pathway Antigen Receptor-mediated Signaling Pathway T Cell Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Immune System Process Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Leukocyte Activation Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction T Cell Costimulation Regulation Of Leukocyte Cell-cell Adhesion Immune Effector Process Regulation Of Signal Transduction
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