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YWHAQ and ITCH
Number of citations of the paper that reports this interaction (PubMedID
31015455
)
58
Data Source:
BioGRID
(enzymatic study)
YWHAQ
ITCH
Description
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
itchy E3 ubiquitin protein ligase
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Focal Adhesion
Membrane
Protein-containing Complex
Synapse
Extracellular Exosome
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Endosome
Early Endosome
Cytosol
Plasma Membrane
Cell Cortex
Endosome Membrane
Membrane
Cytoplasmic Vesicle
Early Endosome Membrane
Protein-containing Complex
Extracellular Exosome
Cell Periphery
Molecular Function
Protein Binding
Protein Domain Specific Binding
Identical Protein Binding
Transmembrane Transporter Binding
14-3-3 Protein Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Transferase Activity
Ligase Activity
Ubiquitin-like Protein Transferase Activity
Ubiquitin-ubiquitin Ligase Activity
Ribonucleoprotein Complex Binding
Ubiquitin-like Protein Ligase Binding
CXCR Chemokine Receptor Binding
Ubiquitin Protein Ligase Activity
Arrestin Family Protein Binding
Biological Process
Protein Targeting
Signal Transduction
Small GTPase-mediated Signal Transduction
Intracellular Protein Localization
Substantia Nigra Development
Negative Regulation Of Monoatomic Ion Transmembrane Transport
Negative Regulation Of DNA-templated Transcription
Protein Polyubiquitination
Regulation Of Cell Growth
Immune System Process
Positive Regulation Of T Cell Anergy
Negative Regulation Of Immune System Process
Positive Regulation Of Immune System Process
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
T Cell Anergy
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Apoptotic Process
Inflammatory Response
Response To Oxidative Stress
Positive Regulation Of Catabolic Process
Regulation Of Gene Expression
Positive Regulation Of Macromolecule Metabolic Process
Protein Ubiquitination
Protein Catabolic Process
Receptor Internalization
Negative Regulation Of Type I Interferon Production
Protein K29-linked Ubiquitination
CD4-positive, Alpha-beta T Cell Proliferation
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
CXCL12-activated CXCR4 Signaling Pathway
Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Negative Regulation Of Apoptotic Process
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Innate Immune Response
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of JNK Cascade
Symbiont Entry Into Host Cell
Negative Regulation Of Defense Response To Virus
Negative Regulation Of Multicellular Organismal Process
Defense Response To Virus
Protein Autoubiquitination
Regulation Of Necroptotic Process
Protein K63-linked Ubiquitination
Protein K48-linked Ubiquitination
Regulation Of Protein Deubiquitination
Protein Branched Polyubiquitination
Regulation Of Hematopoietic Stem Cell Differentiation
Negative Regulation Of Intracellular Signal Transduction
Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation
Positive Regulation Of Receptor Catabolic Process
Pathways
Activation of BAD and translocation to mitochondria
Translocation of SLC2A4 (GLUT4) to the plasma membrane
RHO GTPases activate PKNs
TP53 Regulates Metabolic Genes
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Regulation of localization of FOXO transcription factors
SARS-CoV-1 targets host intracellular signalling and regulatory pathways
SARS-CoV-2 targets host intracellular signalling and regulatory pathways
Downregulation of ERBB4 signaling
NOD1/2 Signaling Pathway
Activated NOTCH1 Transmits Signal to the Nucleus
Activated NOTCH1 Transmits Signal to the Nucleus
Degradation of GLI1 by the proteasome
Hedgehog 'on' state
Regulation of necroptotic cell death
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Negative regulators of DDX58/IFIH1 signaling
SARS-CoV-1 activates/modulates innate immune responses
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Phenethyl Isothiocyanate
Diseases
GWAS
Heart rate variability traits (
22174390
)
Non-response to selective serotonin reuptake inhibitors and depression (
27622933
)
Appendicular lean mass (
33097823
)
Bipolar disorder (
31043756
)
Colorectal cancer or advanced adenoma (
30510241
)
Estimated glomerular filtration rate (
31015462
31152163
)
Fish- and plant-related diet (
32066663
)
Heel bone mineral density (
28869591
)
Hip circumference adjusted for BMI (
34021172
)
Oily fish consumption (
32066663
)
Pork consumption (
32066663
)
Vitiligo (
27723757
)
Interacting Genes
216 interacting genes:
AARS2
ABL1
ACSL4
ADRB2
AGTR1
AHCY
AKT1S1
ANXA1
ANXA2
AR
ARHGAP10
ARHGEF16
ATP5F1A
BAD
BAX
BCAP31
BCR
BRAF
CABIN1
CAPN3
CBL
CBLL1
CCDC125
CDC25A
CDC25B
CDC25C
CDC5L
CDK11B
CDK14
CDK16
CDKN1A
CDKN1B
CFL1
CHAF1A
CKM
CLTC
COPS4
CSE1L
CSNK1A1
CSNK2A1
CTPS1
DAB2IP
DCPS
DDX1
DDX3X
DHX9
DISC1
DNMT1
DYNC1H1
E2F1
EFNB1
EGFR
EIF4A3
ENO1
EPB41
EPB41L1
EPB41L3
ESR1
ESR2
FASN
FBLN1
FGR
FSCN1
FSHR
FXYD1
GAPDH
GCN1
H2BC8
H4C14
HADHA
HAT1
HAX1
HDAC7
HNRNPC
HNRNPH1
HSPA1A
HSPA8
HSPB1
HUS1
IARS2
ING1
ITCH
ITGB4
KANK1
KCNK15
KCNK3
KCNK9
KIF5B
KLC2
KLC3
KRT1
KRT9
LARP1
LARS2
LDHA
LIMA1
LMNA
LMNB1
LYST
MAGOH
MAP3K3
MAP3K5
MCM3
MDM4
MED1
MEF2D
MPL
MPRIP
MRPS27
MST1R
MTNR1B
MTOR
MYCBP2
NADK
NCL
NCOA1
NCOA3
NDE1
NEDD4L
NFATC1
NFATC2
NFATC4
NFKB1
NIF3L1
NME7
NOLC1
NUMA1
PABPN1
PANK1
PDCD6
PDE3A
PDE3B
PDE4B
PDK1
PDPK1
PDXK
PFKFB2
PFKL
PFN1
PGK1
PHLDB2
PI4KB
PIK3C3
PIK3CB
PKM
PRDX1
PRKCQ
PRKCZ
PRKD1
PRKDC
PRMT5
PSME3
RAI14
RCOR3
REM1
RFC1
RGS3
RGS7
RIPK2
RNASE2
RPL10A
RPL15
RPL19
RPL7
RPLP0
RPLP2
RPS3
RUVBL2
SAMSN1
SH3BP2
SKIC8
SLC27A2
SLC8A1
SLC8A2
SLC8A3
SMAD9
SNRPE
SOCS3
SPR
SPTA1
SPTB
SRSF3
SSBP1
SSX2IP
SUMO2
TCP1
TERT
THRA
TLN1
TNF
TNFAIP3
TPI1
TPR
TRAF6
TRIM25
TRIM28
TRIM42
TSC1
TSC2
TUBA1A
TUBA3C
TUBB
UBQLN4
UCP2
UCP3
ULK4
USP8
VARS1
WDR77
WTAP
WWC2
WWP1
YAP1
YWHAG
ZC3H13
ZHX2
132 interacting genes:
AGO2
AKT1
ARHGEF7
ARID1A
ARRB2
ARRDC3
ATN1
BECN1
BIN1
BRAF
CBL
CBLC
CDC34
CPSF6
CPSF7
CSNK2A1
CXCR4
CYLD
DAZAP1
DSCR9
DTX1
DTX3L
ERBB4
ESS2
EWSR1
FYN
GJA1
GLIS3
GNAI2
H1-2
HNRNPUL1
JUN
JUNB
KIAA1210
KPNB1
KSR1
LAPTM5
LITAF
LRRK1
MAP2
MAP2K1
MAP2K4
MAP3K2
MAPK8
MLANA
MLKL
MYCT1
N4BP1
NDFIP1
NDFIP2
NEDD9
NFE2
NOTCH1
NRAS
NUDT21
NUMB
PABPC1
PACSIN1
PIP4P2
POLR2A
POLR2B
POLR2C
POLR2E
POU5F1
PRKACA
PRRG4
RAF1
RBM14
REPS2
RHBDD1
RIPK1
RNF11
RORA
RPAP2
RPAP3
SCNN1A
SCNN1B
SF1
SGK3
SH3GL1
SH3GL2
SIK1
SMAD2
SMAD3
SMARCC1
SMARCC2
SMARCE1
SMN1
SNX9
SPART
SPEN
STAM2
STRIP2
SUFU
TAB1
TAF15
TGFB1I1
TMEM51
TP73
TRERF1
TRPC4
TRPV1
TRPV4
TTYH3
UBAP2
UBAP2L
UBC
UBE2C
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2G1
UBE2J2
UBE2K
UBE2L3
UBE2L6
UBE2M
UBE2O
UBE2Q1
UBE2Q2
UBE2R2
URI1
UVRAG
WASL
WBP2
YWHAQ
YY1
ZC3H14
Entrez ID
10971
83737
HPRD ID
00886
07565
Ensembl ID
ENSG00000134308
ENSG00000078747
Uniprot IDs
P27348
Q96J02
PDB IDs
2BTP
5IQP
6BCR
6BD2
6BQT
6KZG
6KZH
2DMV
2KYK
2NQ3
2P4R
2YSF
3TUG
4ROF
5C7M
5CQ2
5DWS
5DZD
5SXP
Enriched GO Terms of Interacting Partners
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Cytosol
Cytoplasm
Regulation Of Signaling
Regulation Of Cell Communication
Intracellular Signal Transduction
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Regulation Of Multicellular Organismal Process
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Regulation Of Protein Metabolic Process
ATP Binding
Regulation Of Cellular Component Organization
Regulation Of Primary Metabolic Process
Negative Regulation Of Signal Transduction
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Programmed Cell Death
Positive Regulation Of Metabolic Process
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Regulation Of Metabolic Process
Nucleus
Cadherin Binding
Kinase Activity
Negative Regulation Of Programmed Cell Death
Regulation Of Developmental Process
Nucleobase-containing Compound Metabolic Process
Cellular Response To Stress
Nucleotide Binding
Regulation Of Biological Quality
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Protein Metabolic Process
Cell Cortex
Cellular Response To Oxygen-containing Compound
Response To Stress
Protein-containing Complex
Glucose Catabolic Process
Organelle Organization
Positive Regulation Of Multicellular Organismal Process
Macromolecule Metabolic Process
ADP Metabolic Process
RNA Binding
Cellular Response To Lipid
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Extracellular Exosome
Regulation Of Organelle Organization
Positive Regulation Of Cell Population Proliferation
Glycolytic Process
Cellular Response To Hormone Stimulus
Ubiquitin Conjugating Enzyme Activity
Ubiquitin-protein Transferase Activity
Protein Polyubiquitination
Protein K48-linked Ubiquitination
Protein Ubiquitination
Post-translational Protein Modification
Protein Modification By Small Protein Conjugation
Modification-dependent Protein Catabolic Process
Ubiquitin Protein Ligase Binding
Nucleus
Cytosol
Ubiquitin-dependent Protein Catabolic Process
Macromolecule Catabolic Process
Proteolysis Involved In Protein Catabolic Process
ATP Binding
Transferase Activity
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Metabolic Process
Nucleoplasm
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Metabolic Process
Protein Modification Process
Positive Regulation Of Macromolecule Metabolic Process
Nucleotide Binding
WW Domain Binding
Regulation Of Primary Metabolic Process
Protein Binding
Intracellular Signal Transduction
Regulation Of RNA Metabolic Process
Positive Regulation Of Signal Transduction
Regulation Of Protein Modification Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Intracellular Signaling Cassette
Cytoplasm
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Regulation Of Cell Differentiation
Macromolecule Metabolic Process
Positive Regulation Of RNA Metabolic Process
Protein K11-linked Ubiquitination
Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Modification Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of Protein Ubiquitination
Negative Regulation Of Metabolic Process
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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