TLN1 and TPTE

Number of citations of the paper that reports this interaction (PubMedID 35044719)
104

Data Source:
BioGRID (unspecified method)

		TLN1	TPTE
Description		talin 1	transmembrane phosphatase with tensin homology
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Extracellular Region Cytoplasm Cytosol Cytoskeleton Plasma Membrane Adherens Junction Focal Adhesion Cell Surface Membrane Ruffle Membrane Cell Projection Extracellular Exosome Anchoring Junction	Cytosol Membrane
	Molecular Function	Phosphatidylserine Binding Actin Binding Integrin Binding Structural Constituent Of Cytoskeleton Protein Binding Vinculin Binding LIM Domain Binding Phosphatidylinositol Binding Cadherin Binding Actin Filament Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Monoatomic Ion Channel Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Hydrolase Activity Phosphatase Activity
	Biological Process	Cell-cell Junction Assembly Cell-substrate Junction Assembly Cell Adhesion Integrin-mediated Signaling Pathway Actin Cytoskeleton Organization Cortical Actin Cytoskeleton Organization Integrin Activation Cortical Microtubule Organization Regulation Of Focal Adhesion Assembly Platelet Aggregation Cell-cell Adhesion	Protein Dephosphorylation Phosphate-containing Compound Metabolic Process Monoatomic Ion Transport Signal Transduction Monoatomic Ion Transmembrane Transport Transmembrane Transport
Pathways		Platelet degranulation Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins XBP1(S) activates chaperone genes SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Smooth Muscle Contraction MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	Synthesis of PIPs at the Golgi membrane
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) IgE levels in asthmatics ( 23967269) Lymphocyte count ( 32888494) Monocyte count ( 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 32888494)	Celiac disease ( 23936387)
Interacting Genes		37 interacting genes: ABI1 ACTA1 ARHGAP31 AZIN2 CDK5 CEBPA DAG1 DOK1 EGFR ERBB2 FMO1 HSP90AA1 ITGA1 ITGA2B ITGB1 ITGB2 ITGB3 ITGB5 ITGB7 LRP2 MTNR1A MTNR1B NRAP NYAP1 PIP5K1C PKD1 PTK2 PTK2B PXN RET SMURF1 SUMO2 TES TPTE TUBA1A VCL YWHAQ	12 interacting genes: ADRB2 EPHA1 EPHA2 EPHA3 ERBB3 MEOX2 NTRK1 PDGFRB PTK7 ROR2 TLN1 TUBB3
Entrez ID		7094	7179
HPRD ID		01726	05064
Ensembl ID		ENSG00000137076	ENSG00000274391
Uniprot IDs		Q9Y490	P56180
PDB IDs		1SYQ 2MWN 4DJ9 6R9T
Enriched GO Terms of Interacting Partners?		Focal Adhesion Cell-matrix Adhesion Cell-substrate Adhesion Integrin Complex Integrin-mediated Signaling Pathway Cell Migration Receptor Complex Cell Motility Cell Adhesion Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Signal Transduction Cell Adhesion Mediated By Integrin Lamellipodium Enzyme-linked Receptor Protein Signaling Pathway Filopodium Virus Receptor Activity Regulation Of Protein Metabolic Process Cell Surface Anchoring Junction Cell Projection Symbiont Entry Into Host Cell Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Plasma Membrane Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Extracellular Exosome Signal Complex Assembly Developmental Process Integrin Binding Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Protein Metabolic Process Heterotypic Cell-cell Adhesion Biological Process Involved In Interaction With Host Neuron Projection Morphogenesis Protein Phosphatase Binding Vinculin Binding Cell Projection Morphogenesis Cell Projection Organization Ruffle Membrane Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Wound Healing, Spreading Of Epidermal Cells Integrin Alpha1-beta1 Complex Regulation Of Cell Migration Positive Regulation Of Fibroblast Migration Regulation Of Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Adhesion Anatomical Structure Morphogenesis Regulation Of Cell-matrix Adhesion Regulation Of Cell Development	Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Receptor Complex Protein Kinase Activity Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Ephrin Receptor Signaling Pathway Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Ephrin Receptor Activity ATP Binding Signal Transduction Positive Regulation Of Cellular Component Organization Nucleotide Binding Peptidyl-tyrosine Phosphorylation GPI-linked Ephrin Receptor Activity Neuron Projection Guidance Axon Guidance Regulation Of Cell Junction Assembly Angiogenesis Transmembrane-ephrin Receptor Activity Regulation Of Cellular Component Organization Regulation Of MAPK Cascade Transferase Activity Plasma Membrane Neuron Differentiation Tissue Development Regulation Of Cell-matrix Adhesion Regulation Of GTPase Activity Axon Regulation Of Cell Adhesion Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Neuron Projection Development Focal Adhesion Cell Adhesion Positive Regulation Of MAPK Cascade Cranial Nerve Development Neuron Projection Development Regulation Of Cell Migration Response To Wounding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Motility Growth Factor Binding Positive Regulation Of Cell Migration Regulation Of Catalytic Activity Regulation Of Cell-substrate Adhesion Nerve Development Regulation Of Locomotion Positive Regulation Of Cell Motility Cellular Response To Amyloid-beta
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